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Gene: ATAT1 |
Gene summary for ATAT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ATAT1 | Gene ID | 79969 |
| Gene name | alpha tubulin acetyltransferase 1 | |
| Gene Alias | C6orf134 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A1U9X797 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79969 | ATAT1 | LZE7T | Human | Esophagus | ESCC | 9.91e-05 | 3.69e-01 | 0.0667 |
| 79969 | ATAT1 | LZE8T | Human | Esophagus | ESCC | 2.43e-02 | 2.03e-01 | 0.067 |
| 79969 | ATAT1 | LZE22T | Human | Esophagus | ESCC | 1.02e-06 | 3.05e-01 | 0.068 |
| 79969 | ATAT1 | LZE24T | Human | Esophagus | ESCC | 5.23e-10 | 2.87e-01 | 0.0596 |
| 79969 | ATAT1 | P2T-E | Human | Esophagus | ESCC | 1.15e-18 | 3.46e-01 | 0.1177 |
| 79969 | ATAT1 | P4T-E | Human | Esophagus | ESCC | 1.38e-17 | 3.90e-01 | 0.1323 |
| 79969 | ATAT1 | P5T-E | Human | Esophagus | ESCC | 3.46e-06 | 7.65e-02 | 0.1327 |
| 79969 | ATAT1 | P8T-E | Human | Esophagus | ESCC | 2.78e-14 | 2.63e-01 | 0.0889 |
| 79969 | ATAT1 | P9T-E | Human | Esophagus | ESCC | 3.44e-04 | 1.19e-01 | 0.1131 |
| 79969 | ATAT1 | P10T-E | Human | Esophagus | ESCC | 1.73e-16 | 3.14e-01 | 0.116 |
| 79969 | ATAT1 | P11T-E | Human | Esophagus | ESCC | 2.85e-03 | 2.50e-01 | 0.1426 |
| 79969 | ATAT1 | P12T-E | Human | Esophagus | ESCC | 2.54e-11 | 2.23e-01 | 0.1122 |
| 79969 | ATAT1 | P15T-E | Human | Esophagus | ESCC | 1.72e-04 | 1.10e-01 | 0.1149 |
| 79969 | ATAT1 | P16T-E | Human | Esophagus | ESCC | 9.56e-23 | 3.58e-01 | 0.1153 |
| 79969 | ATAT1 | P20T-E | Human | Esophagus | ESCC | 3.41e-09 | 2.37e-01 | 0.1124 |
| 79969 | ATAT1 | P21T-E | Human | Esophagus | ESCC | 9.87e-12 | 1.36e-01 | 0.1617 |
| 79969 | ATAT1 | P22T-E | Human | Esophagus | ESCC | 1.20e-19 | 2.87e-01 | 0.1236 |
| 79969 | ATAT1 | P23T-E | Human | Esophagus | ESCC | 3.96e-10 | 2.33e-01 | 0.108 |
| 79969 | ATAT1 | P24T-E | Human | Esophagus | ESCC | 1.94e-10 | 1.74e-01 | 0.1287 |
| 79969 | ATAT1 | P26T-E | Human | Esophagus | ESCC | 1.39e-04 | 1.34e-01 | 0.1276 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
| GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
| GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
| GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
| GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
| GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
| GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
| GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
| GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
| GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
| GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
| GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
| GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ATAT1 | insertion | Frame_Shift_Ins | novel | c.739_740insACATACATGATGGAGAATCTCTTGAGAGGGAAAGCCG | p.Arg247HisfsTer65 | p.R247Hfs*65 | Q5SQI0 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ATAT1 | SNV | Missense_Mutation | c.878N>A | p.Arg293His | p.R293H | Q5SQI0 | protein_coding | tolerated(0.18) | possibly_damaging(0.861) | TCGA-AA-3495-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | SNV | Missense_Mutation | c.925C>T | p.Arg309Cys | p.R309C | Q5SQI0 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | SNV | Missense_Mutation | c.827A>C | p.Glu276Ala | p.E276A | Q5SQI0 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | SNV | Missense_Mutation | novel | c.25N>G | p.Phe9Val | p.F9V | Q5SQI0 | protein_coding | tolerated_low_confidence(0.26) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ATAT1 | SNV | Missense_Mutation | c.53G>A | p.Gly18Glu | p.G18E | Q5SQI0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-F4-6854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | SNV | Missense_Mutation | c.1013G>A | p.Gly338Asp | p.G338D | Q5SQI0 | protein_coding | tolerated(0.07) | probably_damaging(0.934) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | SNV | Missense_Mutation | c.1108N>G | p.Met370Val | p.M370V | Q5SQI0 | protein_coding | tolerated(0.94) | benign(0) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ATAT1 | deletion | Frame_Shift_Del | c.858delN | p.Pro288HisfsTer31 | p.P288Hfs*31 | Q5SQI0 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
| ATAT1 | deletion | Frame_Shift_Del | c.858delN | p.Pro288HisfsTer31 | p.P288Hfs*31 | Q5SQI0 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 79969 | ATAT1 | ENZYME | gemcitabine | GEMCITABINE | 31616045 | |
| 79969 | ATAT1 | ENZYME | carboplatin | CARBOPLATIN | 31616045 |
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