Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ASCL2

Gene summary for ASCL2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ASCL2

Gene ID

430

Gene nameachaete-scute family bHLH transcription factor 2
Gene AliasASH2
Cytomap11p15.5
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q99929


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
430ASCL2HTA11_3410_2000001011HumanColorectumAD5.61e-113.47e-010.0155
430ASCL2HTA11_2951_2000001011HumanColorectumAD4.24e-129.82e-010.0216
430ASCL2HTA11_1938_2000001011HumanColorectumAD2.00e-044.40e-01-0.0811
430ASCL2HTA11_3361_2000001011HumanColorectumAD3.88e-023.69e-01-0.1207
430ASCL2HTA11_696_2000001011HumanColorectumAD3.29e-135.95e-01-0.1464
430ASCL2HTA11_866_2000001011HumanColorectumAD4.98e-022.02e-01-0.1001
430ASCL2HTA11_1391_2000001011HumanColorectumAD5.85e-199.21e-01-0.059
430ASCL2HTA11_866_3004761011HumanColorectumAD2.29e-621.56e+000.096
430ASCL2HTA11_9408_2000001011HumanColorectumAD3.79e-191.35e+000.0451
430ASCL2HTA11_8622_2000001021HumanColorectumSER6.44e-107.35e-010.0528
430ASCL2HTA11_7663_2000001011HumanColorectumSER9.65e-058.67e-010.0131
430ASCL2HTA11_10711_2000001011HumanColorectumAD6.97e-311.17e+000.0338
430ASCL2HTA11_7696_3000711011HumanColorectumAD9.60e-631.50e+000.0674
430ASCL2HTA11_6818_2000001011HumanColorectumAD2.92e-151.20e+000.0112
430ASCL2HTA11_11156_2000001011HumanColorectumAD4.45e-121.26e+000.0397
430ASCL2HTA11_6818_2000001021HumanColorectumAD9.50e-401.39e+000.0588
430ASCL2HTA11_99999970781_79442HumanColorectumMSS4.80e-277.49e-010.294
430ASCL2HTA11_99999965062_69753HumanColorectumMSI-H5.05e-059.32e-010.3487
430ASCL2HTA11_99999965104_69814HumanColorectumMSS7.20e-391.35e+000.281
430ASCL2HTA11_99999971662_82457HumanColorectumMSS2.40e-491.10e+000.3859
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:0001890ColorectumADplacenta development51/3918144/187233.99e-057.16e-0451
GO:0001892ColorectumADembryonic placenta development33/391882/187235.30e-059.01e-0433
GO:0070482ColorectumADresponse to oxygen levels99/3918347/187234.29e-044.82e-0399
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:0001666ColorectumADresponse to hypoxia86/3918307/187231.77e-031.46e-0286
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:0050767ColorectumADregulation of neurogenesis99/3918364/187232.35e-031.82e-0299
GO:0036293ColorectumADresponse to decreased oxygen levels88/3918322/187233.42e-032.49e-0288
GO:0048568ColorectumADembryonic organ development112/3918427/187234.60e-033.14e-02112
GO:00018901ColorectumSERplacenta development43/2897144/187239.10e-063.03e-0443
GO:00018921ColorectumSERembryonic placenta development28/289782/187232.24e-056.43e-0428
GO:00704821ColorectumSERresponse to oxygen levels79/2897347/187231.99e-043.64e-0379
GO:00016661ColorectumSERresponse to hypoxia69/2897307/187237.07e-049.39e-0369
GO:00362931ColorectumSERresponse to decreased oxygen levels71/2897322/187231.04e-031.22e-0271
GO:00017011ColorectumSERin utero embryonic development77/2897367/187232.77e-032.48e-0277
GO:00614581ColorectumSERreproductive system development87/2897427/187233.69e-033.07e-0287
GO:00486081ColorectumSERreproductive structure development85/2897424/187236.33e-034.56e-0285
GO:00018902ColorectumMSSplacenta development51/3467144/187231.10e-063.77e-0551
GO:00614582ColorectumMSSreproductive system development115/3467427/187239.86e-062.39e-04115
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ASCL2M1MACBreastDCISFGFBP2,SPON2,KLRF1, etc.1.12e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2DCBreastDCISFGFBP2,SPON2,KLRF1, etc.1.12e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2DCBreastHealthyFGFBP2,SPON2,KLRF1, etc.4.03e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2M1MACBreastHealthyFGFBP2,SPON2,KLRF1, etc.4.26e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2M1MACBreastIDCFGFBP2,SPON2,KLRF1, etc.2.36e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2DCBreastIDCFGFBP2,SPON2,KLRF1, etc.9.54e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2INMONBreastIDCFGFBP2,SPON2,KLRF1, etc.1.46e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2MONBreastIDCFGFBP2,SPON2,KLRF1, etc.4.80e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2INMONBreastPrecancerFGFBP2,SPON2,KLRF1, etc.3.50e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ASCL2BASCervixHSIL_HPVLPAR5,MYLPF,NKD2, etc.7.58e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ASCL2SNVMissense_Mutationnovelc.127N>Tp.Ala43Serp.A43SQ99929protein_codingtolerated(0.97)benign(0.003)TCGA-A6-6780-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ASCL2SNVMissense_Mutationnovelc.298N>Gp.Arg100Glyp.R100GQ99929protein_codingdeleterious(0)possibly_damaging(0.581)TCGA-2Y-A9GW-01Liverliver hepatocellular carcinomaMale<65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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