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Gene: ASB8 |
Gene summary for ASB8 |
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Gene information | Species | Human | Gene symbol | ASB8 | Gene ID | 140461 |
Gene name | ankyrin repeat and SOCS box containing 8 | |
Gene Alias | PP14212 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9H765 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140461 | ASB8 | LZE4T | Human | Esophagus | ESCC | 1.33e-11 | 2.70e-01 | 0.0811 |
140461 | ASB8 | LZE7T | Human | Esophagus | ESCC | 2.81e-02 | 1.39e-01 | 0.0667 |
140461 | ASB8 | LZE8T | Human | Esophagus | ESCC | 2.67e-06 | 2.20e-01 | 0.067 |
140461 | ASB8 | LZE20T | Human | Esophagus | ESCC | 7.62e-06 | 1.94e-01 | 0.0662 |
140461 | ASB8 | LZE24T | Human | Esophagus | ESCC | 9.14e-12 | 2.92e-01 | 0.0596 |
140461 | ASB8 | LZE6T | Human | Esophagus | ESCC | 3.03e-04 | 1.64e-01 | 0.0845 |
140461 | ASB8 | P1T-E | Human | Esophagus | ESCC | 1.27e-09 | 3.42e-01 | 0.0875 |
140461 | ASB8 | P2T-E | Human | Esophagus | ESCC | 1.06e-36 | 5.68e-01 | 0.1177 |
140461 | ASB8 | P4T-E | Human | Esophagus | ESCC | 1.91e-10 | 2.48e-01 | 0.1323 |
140461 | ASB8 | P5T-E | Human | Esophagus | ESCC | 3.85e-09 | 9.98e-02 | 0.1327 |
140461 | ASB8 | P8T-E | Human | Esophagus | ESCC | 7.50e-26 | 4.48e-01 | 0.0889 |
140461 | ASB8 | P9T-E | Human | Esophagus | ESCC | 1.57e-07 | 1.78e-01 | 0.1131 |
140461 | ASB8 | P10T-E | Human | Esophagus | ESCC | 2.37e-17 | 3.35e-01 | 0.116 |
140461 | ASB8 | P11T-E | Human | Esophagus | ESCC | 7.55e-09 | 2.79e-01 | 0.1426 |
140461 | ASB8 | P12T-E | Human | Esophagus | ESCC | 5.46e-21 | 2.89e-01 | 0.1122 |
140461 | ASB8 | P15T-E | Human | Esophagus | ESCC | 1.86e-29 | 2.18e-01 | 0.1149 |
140461 | ASB8 | P16T-E | Human | Esophagus | ESCC | 2.38e-21 | 4.30e-01 | 0.1153 |
140461 | ASB8 | P17T-E | Human | Esophagus | ESCC | 9.50e-08 | 3.59e-01 | 0.1278 |
140461 | ASB8 | P19T-E | Human | Esophagus | ESCC | 1.29e-04 | 2.89e-01 | 0.1662 |
140461 | ASB8 | P20T-E | Human | Esophagus | ESCC | 7.79e-26 | 5.66e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASB8 | SNV | Missense_Mutation | c.657N>C | p.Glu219Asp | p.E219D | Q9H765 | protein_coding | tolerated(0.37) | benign(0.01) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ASB8 | SNV | Missense_Mutation | rs747598837 | c.71N>A | p.Arg24Gln | p.R24Q | Q9H765 | protein_coding | tolerated(0.08) | benign(0.124) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ASB8 | SNV | Missense_Mutation | novel | c.131N>A | p.Gly44Glu | p.G44E | Q9H765 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ASB8 | SNV | Missense_Mutation | novel | c.136G>A | p.Asp46Asn | p.D46N | Q9H765 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ASB8 | SNV | Missense_Mutation | rs868063048 | c.80N>T | p.Ala27Val | p.A27V | Q9H765 | protein_coding | deleterious(0.04) | possibly_damaging(0.685) | TCGA-AA-3875-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASB8 | deletion | Frame_Shift_Del | novel | c.7delN | p.Ser3ProfsTer20 | p.S3Pfs*20 | Q9H765 | protein_coding | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD | ||
ASB8 | SNV | Missense_Mutation | novel | c.523G>A | p.Ala175Thr | p.A175T | Q9H765 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASB8 | SNV | Missense_Mutation | rs747598837 | c.71N>A | p.Arg24Gln | p.R24Q | Q9H765 | protein_coding | tolerated(0.08) | benign(0.124) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ASB8 | SNV | Missense_Mutation | rs565893897 | c.61N>T | p.Arg21Cys | p.R21C | Q9H765 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASB8 | SNV | Missense_Mutation | c.403N>T | p.Arg135Trp | p.R135W | Q9H765 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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