![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ASB6 |
Gene summary for ASB6 |
![]() |
Gene information | Species | Human | Gene symbol | ASB6 | Gene ID | 140459 |
Gene name | ankyrin repeat and SOCS box containing 6 | |
Gene Alias | ASB6 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | F6TX30 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140459 | ASB6 | LZE7T | Human | Esophagus | ESCC | 8.92e-03 | 9.43e-02 | 0.0667 |
140459 | ASB6 | LZE20T | Human | Esophagus | ESCC | 2.50e-02 | 1.22e-01 | 0.0662 |
140459 | ASB6 | LZE24T | Human | Esophagus | ESCC | 2.10e-07 | 1.69e-01 | 0.0596 |
140459 | ASB6 | P1T-E | Human | Esophagus | ESCC | 1.72e-05 | 2.14e-01 | 0.0875 |
140459 | ASB6 | P2T-E | Human | Esophagus | ESCC | 2.33e-22 | 2.93e-01 | 0.1177 |
140459 | ASB6 | P4T-E | Human | Esophagus | ESCC | 6.74e-15 | 2.09e-01 | 0.1323 |
140459 | ASB6 | P5T-E | Human | Esophagus | ESCC | 4.02e-14 | 1.39e-01 | 0.1327 |
140459 | ASB6 | P8T-E | Human | Esophagus | ESCC | 1.35e-15 | 2.99e-01 | 0.0889 |
140459 | ASB6 | P9T-E | Human | Esophagus | ESCC | 3.12e-03 | 1.05e-01 | 0.1131 |
140459 | ASB6 | P10T-E | Human | Esophagus | ESCC | 2.49e-16 | 1.23e-01 | 0.116 |
140459 | ASB6 | P11T-E | Human | Esophagus | ESCC | 6.49e-11 | 2.99e-01 | 0.1426 |
140459 | ASB6 | P12T-E | Human | Esophagus | ESCC | 1.03e-06 | 1.05e-01 | 0.1122 |
140459 | ASB6 | P15T-E | Human | Esophagus | ESCC | 2.08e-10 | 1.11e-01 | 0.1149 |
140459 | ASB6 | P16T-E | Human | Esophagus | ESCC | 4.04e-12 | 1.41e-01 | 0.1153 |
140459 | ASB6 | P17T-E | Human | Esophagus | ESCC | 1.27e-02 | 1.58e-01 | 0.1278 |
140459 | ASB6 | P20T-E | Human | Esophagus | ESCC | 4.81e-04 | 1.38e-01 | 0.1124 |
140459 | ASB6 | P21T-E | Human | Esophagus | ESCC | 5.06e-13 | 2.64e-01 | 0.1617 |
140459 | ASB6 | P22T-E | Human | Esophagus | ESCC | 9.16e-06 | 6.38e-02 | 0.1236 |
140459 | ASB6 | P23T-E | Human | Esophagus | ESCC | 2.86e-10 | 1.71e-01 | 0.108 |
140459 | ASB6 | P24T-E | Human | Esophagus | ESCC | 1.63e-16 | 2.39e-01 | 0.1287 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASB6 | SNV | Missense_Mutation | c.292G>A | p.Glu98Lys | p.E98K | Q9NWX5 | protein_coding | tolerated(0.22) | benign(0.067) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ASB6 | SNV | Missense_Mutation | rs145932765 | c.1064N>T | p.Ala355Val | p.A355V | Q9NWX5 | protein_coding | tolerated_low_confidence(0.06) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASB6 | SNV | Missense_Mutation | rs774218305 | c.581N>A | p.Arg194His | p.R194H | Q9NWX5 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASB6 | SNV | Missense_Mutation | rs764592974 | c.448N>T | p.Arg150Cys | p.R150C | Q9NWX5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ASB6 | SNV | Missense_Mutation | c.1165N>T | p.Pro389Ser | p.P389S | Q9NWX5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ASB6 | SNV | Missense_Mutation | rs370764640 | c.881N>T | p.Ala294Val | p.A294V | Q9NWX5 | protein_coding | tolerated(0.07) | benign(0.03) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASB6 | SNV | Missense_Mutation | novel | c.192N>G | p.Phe64Leu | p.F64L | Q9NWX5 | protein_coding | tolerated(0.28) | benign(0.159) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ASB6 | SNV | Missense_Mutation | novel | c.64N>A | p.Leu22Met | p.L22M | Q9NWX5 | protein_coding | tolerated_low_confidence(0.33) | benign(0.255) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ASB6 | SNV | Missense_Mutation | novel | c.1110C>A | p.Ser370Arg | p.S370R | Q9NWX5 | protein_coding | tolerated(0.44) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASB6 | SNV | Missense_Mutation | novel | c.1193C>T | p.Ala398Val | p.A398V | Q9NWX5 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.862) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |