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Gene: ASB3 |
Gene summary for ASB3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ASB3 | Gene ID | 51130 |
| Gene name | ankyrin repeat and SOCS box containing 3 | |
| Gene Alias | ASB-3 | |
| Cytomap | 2p16.2 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y575 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51130 | ASB3 | CCI_1 | Human | Cervix | CC | 2.05e-05 | 6.49e-01 | 0.528 |
| 51130 | ASB3 | CCI_2 | Human | Cervix | CC | 1.58e-06 | 7.92e-01 | 0.5249 |
| 51130 | ASB3 | CCI_3 | Human | Cervix | CC | 6.89e-04 | 5.15e-01 | 0.516 |
| 51130 | ASB3 | T3 | Human | Cervix | CC | 1.60e-04 | 1.17e-01 | 0.1389 |
| 51130 | ASB3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.77e-05 | 1.02e-01 | 0.0155 |
| 51130 | ASB3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.11e-10 | 5.43e-01 | -0.1808 |
| 51130 | ASB3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.40e-14 | 6.01e-01 | -0.0811 |
| 51130 | ASB3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.81e-10 | 4.66e-01 | -0.1088 |
| 51130 | ASB3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.48e-24 | 6.17e-01 | -0.1954 |
| 51130 | ASB3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.30e-08 | 3.38e-01 | -0.1207 |
| 51130 | ASB3 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.58e-04 | 3.76e-01 | -0.1526 |
| 51130 | ASB3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.59e-21 | 4.23e-01 | -0.1464 |
| 51130 | ASB3 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.23e-17 | 3.59e-01 | -0.1001 |
| 51130 | ASB3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.65e-14 | 5.02e-01 | -0.059 |
| 51130 | ASB3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.08e-05 | 4.74e-01 | -0.1706 |
| 51130 | ASB3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.07e-05 | 4.10e-01 | -0.0842 |
| 51130 | ASB3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.73e-04 | 3.40e-01 | -0.0179 |
| 51130 | ASB3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.12e-05 | 2.02e-01 | 0.096 |
| 51130 | ASB3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.93e-03 | 2.36e-01 | 0.0528 |
| 51130 | ASB3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.67e-06 | 5.74e-01 | 0.0131 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
| GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
| GO:00551174 | Cervix | CC | regulation of cardiac muscle contraction | 18/2311 | 77/18723 | 5.15e-03 | 3.03e-02 | 18 |
| GO:00902578 | Cervix | CC | regulation of muscle system process | 45/2311 | 252/18723 | 6.73e-03 | 3.70e-02 | 45 |
| GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
| GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
| GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
| GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
| GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
| GO:00902571 | Colorectum | SER | regulation of muscle system process | 60/2897 | 252/18723 | 3.28e-04 | 5.22e-03 | 60 |
| GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
| GO:0055117 | Colorectum | SER | regulation of cardiac muscle contraction | 21/2897 | 77/18723 | 5.54e-03 | 4.09e-02 | 21 |
| GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
| GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
| GO:00902572 | Colorectum | MSS | regulation of muscle system process | 66/3467 | 252/18723 | 1.55e-03 | 1.41e-02 | 66 |
| GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
| GO:00726593 | Colorectum | MSI-H | protein localization to plasma membrane | 38/1319 | 284/18723 | 1.03e-04 | 3.18e-03 | 38 |
| GO:19907783 | Colorectum | MSI-H | protein localization to cell periphery | 40/1319 | 333/18723 | 6.61e-04 | 1.27e-02 | 40 |
| GO:0006937 | Colorectum | MSI-H | regulation of muscle contraction | 24/1319 | 169/18723 | 7.87e-04 | 1.46e-02 | 24 |
| GO:00551171 | Colorectum | MSI-H | regulation of cardiac muscle contraction | 14/1319 | 77/18723 | 8.78e-04 | 1.57e-02 | 14 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ASB3 | SNV | Missense_Mutation | novel | c.1066N>A | p.Glu356Lys | p.E356K | Q9Y575 | protein_coding | tolerated(0.26) | benign(0.012) | TCGA-S3-A6ZH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
| ASB3 | insertion | Nonsense_Mutation | novel | c.833_834insTTTTTGAGACAGGGTCTCACTCTGTGG | p.Leu278_Asn279insPheTerAspArgValSerLeuCysGly | p.L278_N279insF*DRVSLCG | Q9Y575 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
| ASB3 | SNV | Missense_Mutation | c.292C>T | p.Leu98Phe | p.L98F | Q9Y575 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ASB3 | SNV | Missense_Mutation | novel | c.169G>A | p.Glu57Lys | p.E57K | Q9Y575 | protein_coding | tolerated(0.12) | benign(0.096) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| ASB3 | SNV | Missense_Mutation | rs144642593 | c.1394G>A | p.Val466Met | p.V466M | protein_coding | benign(0.001) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ASB3 | SNV | Missense_Mutation | novel | c.922N>T | p.Ala308Ser | p.A308S | Q9Y575 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AA-3971-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR |
| ASB3 | SNV | Missense_Mutation | c.422C>T | p.Ser141Phe | p.S141F | Q9Y575 | protein_coding | tolerated(0.3) | benign(0.06) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
| ASB3 | SNV | Missense_Mutation | novel | c.122N>C | p.Asn41Thr | p.N41T | Q9Y575 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ASB3 | SNV | Missense_Mutation | novel | c.323C>G | p.Thr108Ser | p.T108S | Q9Y575 | protein_coding | tolerated(0.29) | benign(0.082) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD |
| ASB3 | SNV | Missense_Mutation | c.1004A>G | p.Asn335Ser | p.N335S | Q9Y575 | protein_coding | tolerated(0.57) | benign(0.079) | TCGA-CM-4750-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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