Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ASAP2

Gene summary for ASAP2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ASAP2

Gene ID

8853

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Gene AliasAMAP2
Cytomap2p25.1
Gene Typeprotein-coding
GO ID

GO:0008150

UniProtAcc

O43150


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8853ASAP2CCI_1HumanCervixCC1.19e-108.40e-010.528
8853ASAP2CCI_3HumanCervixCC2.51e-107.88e-010.516
8853ASAP2sample3HumanCervixCC1.36e-041.90e-010.1387
8853ASAP2T3HumanCervixCC9.54e-052.34e-010.1389
8853ASAP2HTA11_347_2000001011HumanColorectumAD2.04e-074.48e-01-0.1954
8853ASAP2HTA11_866_3004761011HumanColorectumAD4.94e-05-3.11e-010.096
8853ASAP2HTA11_10711_2000001011HumanColorectumAD7.23e-03-3.61e-010.0338
8853ASAP2HTA11_99999974143_84620HumanColorectumMSS4.30e-06-3.35e-010.3005
8853ASAP2A015-C-203HumanColorectumFAP2.61e-22-4.07e-01-0.1294
8853ASAP2A014-C-040HumanColorectumFAP1.45e-02-3.40e-01-0.1184
8853ASAP2A002-C-201HumanColorectumFAP4.24e-06-2.49e-010.0324
8853ASAP2A001-C-119HumanColorectumFAP5.12e-06-3.19e-01-0.1557
8853ASAP2A001-C-108HumanColorectumFAP1.01e-11-1.93e-01-0.0272
8853ASAP2A002-C-205HumanColorectumFAP4.48e-14-3.36e-01-0.1236
8853ASAP2A015-C-006HumanColorectumFAP8.36e-11-3.41e-01-0.0994
8853ASAP2A015-C-106HumanColorectumFAP3.11e-05-1.51e-01-0.0511
8853ASAP2A002-C-114HumanColorectumFAP6.64e-13-4.09e-01-0.1561
8853ASAP2A015-C-104HumanColorectumFAP1.29e-21-2.71e-01-0.1899
8853ASAP2A001-C-014HumanColorectumFAP3.59e-09-1.65e-010.0135
8853ASAP2A002-C-016HumanColorectumFAP3.27e-13-2.81e-010.0521
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00430877CervixCCregulation of GTPase activity79/2311348/187234.21e-082.60e-0679
GO:00435476CervixCCpositive regulation of GTPase activity53/2311255/187238.72e-051.16e-0353
GO:0043087ColorectumADregulation of GTPase activity110/3918348/187231.64e-065.03e-05110
GO:0043547ColorectumADpositive regulation of GTPase activity75/3918255/187237.95e-047.91e-0375
GO:00430872ColorectumMSSregulation of GTPase activity101/3467348/187231.00e-063.46e-05101
GO:00435471ColorectumMSSpositive regulation of GTPase activity68/3467255/187237.97e-048.38e-0368
GO:00430873ColorectumFAPregulation of GTPase activity85/2622348/187231.20e-077.68e-0685
GO:00435472ColorectumFAPpositive regulation of GTPase activity61/2622255/187231.39e-053.73e-0461
GO:00430874ColorectumCRCregulation of GTPase activity69/2078348/187231.11e-066.69e-0569
GO:00435473ColorectumCRCpositive regulation of GTPase activity49/2078255/187238.67e-051.77e-0349
GO:004308715EsophagusESCCregulation of GTPase activity183/8552348/187235.34e-032.00e-02183
GO:004308710Oral cavityOSCCregulation of GTPase activity165/7305348/187237.94e-044.27e-03165
GO:004308714Oral cavityEOLPregulation of GTPase activity66/2218348/187236.92e-058.55e-0466
GO:00435479Oral cavityEOLPpositive regulation of GTPase activity47/2218255/187231.34e-039.33e-0347
GO:004308722Oral cavityNEOLPregulation of GTPase activity54/2005348/187233.36e-032.00e-0254
GO:004308718ThyroidPTCregulation of GTPase activity148/5968348/187231.63e-051.71e-04148
GO:004354714ThyroidPTCpositive regulation of GTPase activity103/5968255/187232.38e-031.25e-02103
GO:004308719ThyroidATCregulation of GTPase activity153/6293348/187233.24e-052.68e-04153
GO:004354715ThyroidATCpositive regulation of GTPase activity106/6293255/187234.58e-031.89e-02106
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0414418CervixCCEndocytosis64/1267251/84656.97e-066.10e-053.61e-0564
hsa0466612CervixCCFc gamma R-mediated phagocytosis31/126797/84651.78e-051.42e-048.40e-0531
hsa0414419CervixCCEndocytosis64/1267251/84656.97e-066.10e-053.61e-0564
hsa0466613CervixCCFc gamma R-mediated phagocytosis31/126797/84651.78e-051.42e-048.40e-0531
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa04666ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa046661ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa041444ColorectumMSSEndocytosis102/1875251/84651.85e-114.43e-102.71e-10102
hsa046664ColorectumMSSFc gamma R-mediated phagocytosis45/187597/84659.30e-081.56e-069.55e-0745
hsa041445ColorectumMSSEndocytosis102/1875251/84651.85e-114.43e-102.71e-10102
hsa046665ColorectumMSSFc gamma R-mediated phagocytosis45/187597/84659.30e-081.56e-069.55e-0745
hsa041446ColorectumFAPEndocytosis78/1404251/84656.20e-092.96e-071.80e-0778
hsa046666ColorectumFAPFc gamma R-mediated phagocytosis35/140497/84652.46e-064.28e-052.60e-0535
hsa041447ColorectumFAPEndocytosis78/1404251/84656.20e-092.96e-071.80e-0778
hsa046667ColorectumFAPFc gamma R-mediated phagocytosis35/140497/84652.46e-064.28e-052.60e-0535
hsa041448ColorectumCRCEndocytosis65/1091251/84651.27e-081.06e-067.19e-0765
hsa046668ColorectumCRCFc gamma R-mediated phagocytosis27/109197/84656.24e-051.12e-037.57e-0427
hsa041449ColorectumCRCEndocytosis65/1091251/84651.27e-081.06e-067.19e-0765
hsa046669ColorectumCRCFc gamma R-mediated phagocytosis27/109197/84656.24e-051.12e-037.57e-0427
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ASAP2SNVMissense_Mutationc.1786G>Ap.Val596Metp.V596MO43150protein_codingdeleterious(0)probably_damaging(0.993)TCGA-A2-A0T6-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
ASAP2SNVMissense_Mutationc.959N>Ap.Arg320Glnp.R320QO43150protein_codingdeleterious(0)benign(0.219)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ASAP2SNVMissense_Mutationc.626N>Gp.Lys209Argp.K209RO43150protein_codingdeleterious(0.03)probably_damaging(0.932)TCGA-D8-A27W-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicine+cyclophosphamideSD
ASAP2SNVMissense_Mutationnovelc.2011N>Ap.Glu671Lysp.E671KO43150protein_codingdeleterious(0)benign(0.377)TCGA-OL-A5RW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
ASAP2SNVMissense_Mutationnovelc.1061N>Tp.Cys354Phep.C354FO43150protein_codingdeleterious(0)probably_damaging(0.999)TCGA-S3-AA11-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyletrozoleCR
ASAP2deletionFrame_Shift_Delnovelc.1572delNp.Tyr525ThrfsTer80p.Y525Tfs*80O43150protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
ASAP2SNVMissense_Mutationnovelc.328G>Ap.Ala110Thrp.A110TO43150protein_codingtolerated(0.31)probably_damaging(0.989)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ASAP2SNVMissense_Mutationnovelc.2795C>Ap.Pro932Hisp.P932HO43150protein_codingdeleterious(0)possibly_damaging(0.827)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ASAP2SNVMissense_Mutationnovelc.1624G>Tp.Asp542Tyrp.D542YO43150protein_codingdeleterious(0)probably_damaging(0.998)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
ASAP2SNVMissense_Mutationnovelc.235N>Ap.Leu79Metp.L79MO43150protein_codingtolerated(0.17)probably_damaging(0.98)TCGA-ZJ-AAXU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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