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Gene: ARMCX1 |
Gene summary for ARMCX1 |
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Gene information | Species | Human | Gene symbol | ARMCX1 | Gene ID | 51309 |
Gene name | armadillo repeat containing X-linked 1 | |
Gene Alias | ALEX1 | |
Cytomap | Xq22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024RCI6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51309 | ARMCX1 | male-WTA | Human | Thyroid | PTC | 1.46e-10 | 4.91e-02 | 0.1037 |
51309 | ARMCX1 | PTC01 | Human | Thyroid | PTC | 7.35e-05 | -6.58e-03 | 0.1899 |
51309 | ARMCX1 | PTC05 | Human | Thyroid | PTC | 1.03e-07 | 2.13e-01 | 0.2065 |
51309 | ARMCX1 | PTC06 | Human | Thyroid | PTC | 6.03e-09 | 1.89e-01 | 0.2057 |
51309 | ARMCX1 | PTC07 | Human | Thyroid | PTC | 1.40e-17 | 1.72e-01 | 0.2044 |
51309 | ARMCX1 | ATC12 | Human | Thyroid | ATC | 5.33e-14 | 3.61e-01 | 0.34 |
51309 | ARMCX1 | ATC13 | Human | Thyroid | ATC | 6.65e-20 | 3.74e-01 | 0.34 |
51309 | ARMCX1 | ATC1 | Human | Thyroid | ATC | 3.21e-02 | 1.07e-01 | 0.2878 |
51309 | ARMCX1 | ATC2 | Human | Thyroid | ATC | 6.11e-10 | 7.51e-01 | 0.34 |
51309 | ARMCX1 | ATC4 | Human | Thyroid | ATC | 3.59e-17 | 4.98e-01 | 0.34 |
51309 | ARMCX1 | ATC5 | Human | Thyroid | ATC | 4.47e-18 | 4.14e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048872113 | Thyroid | PTC | homeostasis of number of cells | 125/5968 | 272/18723 | 7.25e-07 | 1.14e-05 | 125 |
GO:00614841 | Thyroid | PTC | hematopoietic stem cell homeostasis | 11/5968 | 18/18723 | 1.00e-02 | 4.07e-02 | 11 |
GO:0048872210 | Thyroid | ATC | homeostasis of number of cells | 135/6293 | 272/18723 | 2.92e-08 | 5.50e-07 | 135 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMCX1 | SNV | Missense_Mutation | c.8N>A | p.Arg3His | p.R3H | Q9P291 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.816) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
ARMCX1 | SNV | Missense_Mutation | c.1315N>A | p.Asp439Asn | p.D439N | Q9P291 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMCX1 | SNV | Missense_Mutation | c.124N>A | p.Glu42Lys | p.E42K | Q9P291 | protein_coding | tolerated_low_confidence(0.29) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARMCX1 | SNV | Missense_Mutation | novel | c.778G>T | p.Asp260Tyr | p.D260Y | Q9P291 | protein_coding | tolerated(0.32) | probably_damaging(0.991) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMCX1 | SNV | Missense_Mutation | novel | c.920C>T | p.Ala307Val | p.A307V | Q9P291 | protein_coding | tolerated(0.25) | possibly_damaging(0.842) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMCX1 | deletion | Frame_Shift_Del | c.484delN | p.Gly163AlafsTer40 | p.G163Afs*40 | Q9P291 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ARMCX1 | SNV | Missense_Mutation | c.223G>C | p.Glu75Gln | p.E75Q | Q9P291 | protein_coding | tolerated_low_confidence(0.29) | benign(0.007) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARMCX1 | SNV | Missense_Mutation | novel | c.1204N>G | p.Asn402Asp | p.N402D | Q9P291 | protein_coding | tolerated(0.6) | benign(0.012) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARMCX1 | SNV | Missense_Mutation | c.415G>A | p.Ala139Thr | p.A139T | Q9P291 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMCX1 | SNV | Missense_Mutation | c.1056A>G | p.Ile352Met | p.I352M | Q9P291 | protein_coding | deleterious(0.03) | probably_damaging(0.968) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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