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Gene: ARMC6 |
Gene summary for ARMC6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ARMC6 | Gene ID | 93436 |
| Gene name | armadillo repeat containing 6 | |
| Gene Alias | R30923_1 | |
| Cytomap | 19p13.11 | |
| Gene Type | protein-coding | GO ID | GO:0002244 | UniProtAcc | Q6NXE6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 93436 | ARMC6 | LZE4T | Human | Esophagus | ESCC | 2.42e-09 | 1.74e-01 | 0.0811 |
| 93436 | ARMC6 | LZE7T | Human | Esophagus | ESCC | 7.53e-03 | 3.80e-01 | 0.0667 |
| 93436 | ARMC6 | LZE24T | Human | Esophagus | ESCC | 9.54e-04 | 2.20e-01 | 0.0596 |
| 93436 | ARMC6 | P1T-E | Human | Esophagus | ESCC | 2.77e-02 | 2.94e-01 | 0.0875 |
| 93436 | ARMC6 | P2T-E | Human | Esophagus | ESCC | 2.86e-11 | 1.93e-01 | 0.1177 |
| 93436 | ARMC6 | P4T-E | Human | Esophagus | ESCC | 4.36e-12 | 3.21e-01 | 0.1323 |
| 93436 | ARMC6 | P5T-E | Human | Esophagus | ESCC | 4.05e-06 | 1.43e-01 | 0.1327 |
| 93436 | ARMC6 | P8T-E | Human | Esophagus | ESCC | 5.63e-10 | 2.50e-01 | 0.0889 |
| 93436 | ARMC6 | P9T-E | Human | Esophagus | ESCC | 2.02e-11 | 2.40e-01 | 0.1131 |
| 93436 | ARMC6 | P10T-E | Human | Esophagus | ESCC | 7.09e-33 | 5.92e-01 | 0.116 |
| 93436 | ARMC6 | P11T-E | Human | Esophagus | ESCC | 7.11e-14 | 3.83e-01 | 0.1426 |
| 93436 | ARMC6 | P12T-E | Human | Esophagus | ESCC | 4.05e-13 | 3.48e-01 | 0.1122 |
| 93436 | ARMC6 | P15T-E | Human | Esophagus | ESCC | 1.12e-16 | 2.55e-01 | 0.1149 |
| 93436 | ARMC6 | P16T-E | Human | Esophagus | ESCC | 3.45e-12 | 2.18e-01 | 0.1153 |
| 93436 | ARMC6 | P17T-E | Human | Esophagus | ESCC | 2.02e-15 | 5.90e-01 | 0.1278 |
| 93436 | ARMC6 | P19T-E | Human | Esophagus | ESCC | 2.38e-03 | 3.86e-01 | 0.1662 |
| 93436 | ARMC6 | P20T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.83e-01 | 0.1124 |
| 93436 | ARMC6 | P21T-E | Human | Esophagus | ESCC | 5.69e-51 | 8.55e-01 | 0.1617 |
| 93436 | ARMC6 | P22T-E | Human | Esophagus | ESCC | 9.52e-12 | 2.07e-01 | 0.1236 |
| 93436 | ARMC6 | P23T-E | Human | Esophagus | ESCC | 3.94e-19 | 4.49e-01 | 0.108 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00022446 | Esophagus | ESCC | hematopoietic progenitor cell differentiation | 66/8552 | 114/18723 | 5.74e-03 | 2.13e-02 | 66 |
| GO:00022445 | Oral cavity | OSCC | hematopoietic progenitor cell differentiation | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
| GO:000224413 | Skin | cSCC | hematopoietic progenitor cell differentiation | 42/4864 | 114/18723 | 6.74e-03 | 3.27e-02 | 42 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ARMC6 | SNV | Missense_Mutation | novel | c.11N>A | p.Arg4Gln | p.R4Q | Q6NXE6 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
| ARMC6 | SNV | Missense_Mutation | c.700C>G | p.His234Asp | p.H234D | Q6NXE6 | protein_coding | tolerated(0.64) | benign(0) | TCGA-C8-A1HN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ARMC6 | SNV | Missense_Mutation | c.1387N>A | p.Gln463Lys | p.Q463K | Q6NXE6 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| ARMC6 | insertion | Frame_Shift_Ins | novel | c.851_852insCATGAGCCACCACGCCTGGCTTCTCTGT | p.Lys284AsnfsTer15 | p.K284Nfs*15 | Q6NXE6 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| ARMC6 | insertion | Frame_Shift_Ins | novel | c.179_180insTCTCCTGCCTCAGCCTCCC | p.Glu60AspfsTer10 | p.E60Dfs*10 | Q6NXE6 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD | ||
| ARMC6 | SNV | Missense_Mutation | novel | c.764N>C | p.Ile255Thr | p.I255T | Q6NXE6 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ARMC6 | SNV | Missense_Mutation | c.1153C>A | p.Gln385Lys | p.Q385K | Q6NXE6 | protein_coding | tolerated(0.19) | possibly_damaging(0.503) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| ARMC6 | SNV | Missense_Mutation | rs754303232 | c.1274N>T | p.Pro425Leu | p.P425L | Q6NXE6 | protein_coding | deleterious(0.01) | benign(0.439) | TCGA-FU-A57G-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ARMC6 | SNV | Missense_Mutation | rs761010517 | c.982N>A | p.Asp328Asn | p.D328N | Q6NXE6 | protein_coding | tolerated(0.33) | benign(0.011) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD |
| ARMC6 | SNV | Missense_Mutation | rs373198003 | c.608N>A | p.Arg203His | p.R203H | Q6NXE6 | protein_coding | deleterious(0.03) | benign(0.073) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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