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Gene: ARL14EP |
Gene summary for ARL14EP |
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Gene information | Species | Human | Gene symbol | ARL14EP | Gene ID | 120534 |
Gene name | ADP ribosylation factor like GTPase 14 effector protein | |
Gene Alias | ARF7EP | |
Cytomap | 11p14.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N8R7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
120534 | ARL14EP | LZE4T | Human | Esophagus | ESCC | 8.02e-09 | 2.82e-01 | 0.0811 |
120534 | ARL14EP | LZE7T | Human | Esophagus | ESCC | 4.01e-02 | 2.49e-01 | 0.0667 |
120534 | ARL14EP | LZE8T | Human | Esophagus | ESCC | 7.72e-03 | 1.43e-01 | 0.067 |
120534 | ARL14EP | LZE24T | Human | Esophagus | ESCC | 1.96e-13 | 2.70e-01 | 0.0596 |
120534 | ARL14EP | P1T-E | Human | Esophagus | ESCC | 4.80e-03 | 1.69e-01 | 0.0875 |
120534 | ARL14EP | P2T-E | Human | Esophagus | ESCC | 1.60e-17 | 3.62e-01 | 0.1177 |
120534 | ARL14EP | P4T-E | Human | Esophagus | ESCC | 1.21e-12 | 2.75e-01 | 0.1323 |
120534 | ARL14EP | P5T-E | Human | Esophagus | ESCC | 2.49e-05 | 1.47e-01 | 0.1327 |
120534 | ARL14EP | P8T-E | Human | Esophagus | ESCC | 4.28e-24 | 3.83e-01 | 0.0889 |
120534 | ARL14EP | P9T-E | Human | Esophagus | ESCC | 2.14e-07 | 2.12e-01 | 0.1131 |
120534 | ARL14EP | P10T-E | Human | Esophagus | ESCC | 1.16e-19 | 2.94e-01 | 0.116 |
120534 | ARL14EP | P11T-E | Human | Esophagus | ESCC | 1.55e-12 | 4.06e-01 | 0.1426 |
120534 | ARL14EP | P12T-E | Human | Esophagus | ESCC | 1.05e-20 | 4.01e-01 | 0.1122 |
120534 | ARL14EP | P15T-E | Human | Esophagus | ESCC | 2.49e-13 | 2.96e-01 | 0.1149 |
120534 | ARL14EP | P16T-E | Human | Esophagus | ESCC | 1.84e-17 | 4.10e-01 | 0.1153 |
120534 | ARL14EP | P17T-E | Human | Esophagus | ESCC | 4.18e-05 | 2.94e-01 | 0.1278 |
120534 | ARL14EP | P19T-E | Human | Esophagus | ESCC | 2.31e-05 | 4.00e-01 | 0.1662 |
120534 | ARL14EP | P20T-E | Human | Esophagus | ESCC | 1.27e-14 | 3.39e-01 | 0.1124 |
120534 | ARL14EP | P21T-E | Human | Esophagus | ESCC | 2.50e-17 | 3.10e-01 | 0.1617 |
120534 | ARL14EP | P22T-E | Human | Esophagus | ESCC | 7.70e-33 | 6.47e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL14EP | SNV | Missense_Mutation | c.683C>G | p.Ser228Cys | p.S228C | Q8N8R7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARL14EP | SNV | Missense_Mutation | c.112N>C | p.Asp38His | p.D38H | Q8N8R7 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.979) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ARL14EP | SNV | Missense_Mutation | c.706N>T | p.Arg236Cys | p.R236C | Q8N8R7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EA-A3QE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ARL14EP | SNV | Missense_Mutation | c.331N>T | p.Pro111Ser | p.P111S | Q8N8R7 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL14EP | SNV | Missense_Mutation | novel | c.280N>A | p.Asp94Asn | p.D94N | Q8N8R7 | protein_coding | tolerated(0.21) | probably_damaging(0.981) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ARL14EP | SNV | Missense_Mutation | novel | c.349N>A | p.Pro117Thr | p.P117T | Q8N8R7 | protein_coding | tolerated(0.26) | probably_damaging(0.991) | TCGA-AA-3679-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | SD |
ARL14EP | SNV | Missense_Mutation | rs199566595 | c.71N>A | p.Arg24His | p.R24H | Q8N8R7 | protein_coding | deleterious_low_confidence(0.05) | benign(0.212) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARL14EP | SNV | Missense_Mutation | novel | c.260A>C | p.Lys87Thr | p.K87T | Q8N8R7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.277) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARL14EP | deletion | Frame_Shift_Del | c.259delN | p.Asn89IlefsTer4 | p.N89Ifs*4 | Q8N8R7 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ARL14EP | deletion | Frame_Shift_Del | c.266delA | p.Asn89IlefsTer4 | p.N89Ifs*4 | Q8N8R7 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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