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Gene: ARHGEF40 |
Gene summary for ARHGEF40 |
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Gene information | Species | Human | Gene symbol | ARHGEF40 | Gene ID | 55701 |
Gene name | Rho guanine nucleotide exchange factor 40 | |
Gene Alias | SOLO | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8TER5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55701 | ARHGEF40 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.77e-07 | 4.16e-01 | -0.1954 |
55701 | ARHGEF40 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.52e-02 | 3.91e-01 | -0.0842 |
55701 | ARHGEF40 | A002-C-010 | Human | Colorectum | FAP | 3.31e-02 | -5.65e-02 | 0.242 |
55701 | ARHGEF40 | A015-C-203 | Human | Colorectum | FAP | 5.00e-11 | -2.09e-01 | -0.1294 |
55701 | ARHGEF40 | A001-C-108 | Human | Colorectum | FAP | 7.08e-03 | 1.30e-02 | -0.0272 |
55701 | ARHGEF40 | A002-C-205 | Human | Colorectum | FAP | 7.01e-03 | -1.67e-01 | -0.1236 |
55701 | ARHGEF40 | A015-C-006 | Human | Colorectum | FAP | 4.38e-02 | -1.63e-01 | -0.0994 |
55701 | ARHGEF40 | A015-C-106 | Human | Colorectum | FAP | 1.87e-02 | -9.30e-02 | -0.0511 |
55701 | ARHGEF40 | A015-C-104 | Human | Colorectum | FAP | 3.47e-09 | -9.08e-02 | -0.1899 |
55701 | ARHGEF40 | A002-C-016 | Human | Colorectum | FAP | 1.83e-04 | -1.31e-01 | 0.0521 |
55701 | ARHGEF40 | A001-C-203 | Human | Colorectum | FAP | 2.66e-02 | 3.70e-02 | -0.0481 |
55701 | ARHGEF40 | A002-C-116 | Human | Colorectum | FAP | 9.76e-10 | -1.88e-01 | -0.0452 |
55701 | ARHGEF40 | F034 | Human | Colorectum | FAP | 3.71e-05 | 1.38e-02 | -0.0665 |
55701 | ARHGEF40 | CRC-1-8810 | Human | Colorectum | CRC | 1.39e-02 | -1.17e-01 | 0.6257 |
55701 | ARHGEF40 | CRC-3-11773 | Human | Colorectum | CRC | 3.82e-04 | -1.83e-01 | 0.2564 |
55701 | ARHGEF40 | NAFLD1 | Human | Liver | NAFLD | 2.66e-07 | 5.94e-01 | -0.04 |
55701 | ARHGEF40 | HCC1_Meng | Human | Liver | HCC | 8.62e-43 | -1.28e-02 | 0.0246 |
55701 | ARHGEF40 | HCC2_Meng | Human | Liver | HCC | 3.34e-14 | 5.52e-02 | 0.0107 |
55701 | ARHGEF40 | S014 | Human | Liver | HCC | 2.70e-12 | 9.01e-01 | 0.2254 |
55701 | ARHGEF40 | S015 | Human | Liver | HCC | 1.01e-10 | 8.44e-01 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:00510564 | Liver | NAFLD | regulation of small GTPase mediated signal transduction | 56/1882 | 302/18723 | 4.62e-06 | 1.75e-04 | 56 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF40 | SNV | Missense_Mutation | novel | c.161C>T | p.Pro54Leu | p.P54L | Q8TER5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ARHGEF40 | SNV | Missense_Mutation | rs764973823 | c.1700C>T | p.Thr567Met | p.T567M | Q8TER5 | protein_coding | tolerated(0.42) | benign(0) | TCGA-B6-A1KC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF40 | SNV | Missense_Mutation | novel | c.4213C>T | p.Arg1405Trp | p.R1405W | Q8TER5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF40 | SNV | Missense_Mutation | c.1940A>G | p.Asn647Ser | p.N647S | Q8TER5 | protein_coding | tolerated(0.52) | benign(0) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF40 | SNV | Missense_Mutation | c.4069N>A | p.Pro1357Thr | p.P1357T | Q8TER5 | protein_coding | tolerated(0.15) | benign(0.013) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
ARHGEF40 | SNV | Missense_Mutation | novel | c.1142G>A | p.Arg381Lys | p.R381K | Q8TER5 | protein_coding | tolerated(0.08) | benign(0.351) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ARHGEF40 | insertion | In_Frame_Ins | novel | c.3698_3699insTGCACAGTACGTGAAGCA | p.Cys1233_Arg1234insAlaGlnTyrValLysHis | p.C1233_R1234insAQYVKH | Q8TER5 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ARHGEF40 | insertion | Nonsense_Mutation | novel | c.1345_1346insTGCCCAATGAGGCTTGTGCCT | p.Lys449delinsMetProAsnGluAlaCysAlaTer | p.K449delinsMPNEACA* | Q8TER5 | protein_coding | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
ARHGEF40 | insertion | Nonsense_Mutation | novel | c.2188_2189insAGTATGATAAATTATTATAATTATTATTTTTAGA | p.Ala730GlufsTer7 | p.A730Efs*7 | Q8TER5 | protein_coding | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ARHGEF40 | deletion | Frame_Shift_Del | rs749402223 | c.2203delN | p.Ala737ProfsTer3 | p.A737Pfs*3 | Q8TER5 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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