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Gene: ARHGEF39 |
Gene summary for ARHGEF39 |
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Gene information | Species | Human | Gene symbol | ARHGEF39 | Gene ID | 84904 |
Gene name | Rho guanine nucleotide exchange factor 39 | |
Gene Alias | C9orf100 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q8N4T4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84904 | ARHGEF39 | HCC1_Meng | Human | Liver | HCC | 1.74e-19 | 4.29e-02 | 0.0246 |
84904 | ARHGEF39 | HCC1 | Human | Liver | HCC | 5.56e-14 | 2.54e+00 | 0.5336 |
84904 | ARHGEF39 | HCC2 | Human | Liver | HCC | 2.05e-18 | 1.17e+00 | 0.5341 |
84904 | ARHGEF39 | HCC5 | Human | Liver | HCC | 8.56e-18 | 1.12e+00 | 0.4932 |
84904 | ARHGEF39 | S014 | Human | Liver | HCC | 3.35e-02 | 2.47e-01 | 0.2254 |
84904 | ARHGEF39 | S015 | Human | Liver | HCC | 1.64e-02 | 2.45e-01 | 0.2375 |
84904 | ARHGEF39 | S016 | Human | Liver | HCC | 5.66e-07 | 3.44e-01 | 0.2243 |
84904 | ARHGEF39 | S028 | Human | Liver | HCC | 7.94e-05 | 3.05e-01 | 0.2503 |
84904 | ARHGEF39 | S029 | Human | Liver | HCC | 1.01e-04 | 2.88e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF39 | SNV | Missense_Mutation | novel | c.565N>A | p.Glu189Lys | p.E189K | Q8N4T4 | protein_coding | tolerated(0.05) | benign(0.207) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGEF39 | SNV | Missense_Mutation | c.545N>C | p.Arg182Pro | p.R182P | Q8N4T4 | protein_coding | deleterious(0.04) | possibly_damaging(0.703) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARHGEF39 | SNV | Missense_Mutation | c.370N>C | p.Asn124His | p.N124H | Q8N4T4 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-BH-A18R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGEF39 | SNV | Missense_Mutation | novel | c.422N>T | p.Gly141Val | p.G141V | Q8N4T4 | protein_coding | tolerated(0.33) | benign(0.268) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF39 | insertion | Nonsense_Mutation | novel | c.358_359insCTGAGGCCCTCAGCTGGAACTGTGGAACTTTAAATTGAAGTGAGGG | p.Gln120ProfsTer13 | p.Q120Pfs*13 | Q8N4T4 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
ARHGEF39 | SNV | Missense_Mutation | novel | c.227N>T | p.Ala76Val | p.A76V | Q8N4T4 | protein_coding | tolerated(0.74) | benign(0.063) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARHGEF39 | SNV | Missense_Mutation | c.875N>T | p.Ser292Leu | p.S292L | Q8N4T4 | protein_coding | deleterious(0) | benign(0.37) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ARHGEF39 | SNV | Missense_Mutation | c.568N>T | p.Thr190Ser | p.T190S | Q8N4T4 | protein_coding | deleterious(0.01) | benign(0.129) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF39 | SNV | Missense_Mutation | c.395N>A | p.Arg132Gln | p.R132Q | Q8N4T4 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ARHGEF39 | insertion | In_Frame_Ins | novel | c.920_921insAAG | p.Glu307_Lys308insArg | p.E307_K308insR | Q8N4T4 | protein_coding | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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