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Gene: ARHGEF38 |
Gene summary for ARHGEF38 |
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Gene information | Species | Human | Gene symbol | ARHGEF38 | Gene ID | 54848 |
Gene name | Rho guanine nucleotide exchange factor 38 | |
Gene Alias | ARHGEF38 | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NXL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54848 | ARHGEF38 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.75e-18 | -6.59e-01 | 0.0155 |
54848 | ARHGEF38 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.62e-07 | -5.75e-01 | -0.1808 |
54848 | ARHGEF38 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.34e-06 | -6.13e-01 | -0.1207 |
54848 | ARHGEF38 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.35e-02 | -4.85e-01 | -0.1526 |
54848 | ARHGEF38 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.32e-10 | -4.63e-01 | -0.1464 |
54848 | ARHGEF38 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.08e-08 | -4.27e-01 | -0.1001 |
54848 | ARHGEF38 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-05 | -5.02e-01 | -0.059 |
54848 | ARHGEF38 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.52e-02 | -6.59e-01 | -0.2061 |
54848 | ARHGEF38 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.54e-04 | -6.30e-01 | -0.0842 |
54848 | ARHGEF38 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.11e-08 | -5.00e-01 | 0.096 |
54848 | ARHGEF38 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.98e-07 | -6.28e-01 | 0.0338 |
54848 | ARHGEF38 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.01e-15 | -5.58e-01 | 0.0674 |
54848 | ARHGEF38 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.53e-02 | -7.82e-01 | 0.0397 |
54848 | ARHGEF38 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.10e-19 | -5.66e-01 | 0.294 |
54848 | ARHGEF38 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.10e-06 | -6.72e-01 | 0.2585 |
54848 | ARHGEF38 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.12e-17 | -5.76e-01 | 0.3005 |
54848 | ARHGEF38 | A015-C-203 | Human | Colorectum | FAP | 3.07e-24 | -3.57e-01 | -0.1294 |
54848 | ARHGEF38 | A015-C-204 | Human | Colorectum | FAP | 2.08e-04 | -3.16e-01 | -0.0228 |
54848 | ARHGEF38 | A002-C-201 | Human | Colorectum | FAP | 2.17e-08 | -1.78e-01 | 0.0324 |
54848 | ARHGEF38 | A001-C-108 | Human | Colorectum | FAP | 2.47e-12 | -2.65e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF38 | SNV | Missense_Mutation | novel | c.2012C>T | p.Ser671Leu | p.S671L | Q9NXL2 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
ARHGEF38 | SNV | Missense_Mutation | c.2173N>G | p.Gln725Glu | p.Q725E | Q9NXL2 | protein_coding | tolerated(0.19) | benign(0.063) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGEF38 | insertion | Frame_Shift_Ins | novel | c.621_622insA | p.Glu209GlyfsTer71 | p.E209Gfs*71 | Q9NXL2 | protein_coding | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
ARHGEF38 | SNV | Missense_Mutation | novel | c.1489N>G | p.Thr497Ala | p.T497A | Q9NXL2 | protein_coding | tolerated(0.73) | benign(0.049) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ARHGEF38 | SNV | Missense_Mutation | novel | c.2161N>A | p.Val721Ile | p.V721I | Q9NXL2 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF38 | SNV | Missense_Mutation | rs749765197 | c.2143N>A | p.Glu715Lys | p.E715K | Q9NXL2 | protein_coding | tolerated(0.21) | benign(0.025) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF38 | SNV | Missense_Mutation | novel | c.1148N>G | p.Asp383Gly | p.D383G | Q9NXL2 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF38 | SNV | Missense_Mutation | rs749765197 | c.2143N>A | p.Glu715Lys | p.E715K | Q9NXL2 | protein_coding | tolerated(0.21) | benign(0.025) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF38 | SNV | Missense_Mutation | c.554N>C | p.Lys185Thr | p.K185T | Q9NXL2 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGEF38 | SNV | Missense_Mutation | novel | c.714N>G | p.Ile238Met | p.I238M | Q9NXL2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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