Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: ARHGEF11

Gene summary for ARHGEF11

Gene summary.

Gene information	Species	Human
	Gene symbol	ARHGEF11
	Gene ID	9826
	Gene name	Rho guanine nucleotide exchange factor 11
	Gene Alias	GTRAP48
	Cytomap	1q23.1
	Gene Type	protein-coding
	GO ID	GO:0001558
	UniProtAcc	O15085

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
9826	ARHGEF11	CCI_1	Human	Cervix	CC	2.19e-06	6.44e-01	0.528
9826	ARHGEF11	CCI_3	Human	Cervix	CC	1.82e-14	8.42e-01	0.516
9826	ARHGEF11	HTA11_3410_2000001011	Human	Colorectum	AD	8.20e-04	-3.10e-01	0.0155
9826	ARHGEF11	HTA11_99999970781_79442	Human	Colorectum	MSS	3.48e-04	-2.26e-01	0.294
9826	ARHGEF11	HTA11_99999974143_84620	Human	Colorectum	MSS	8.81e-05	-2.88e-01	0.3005
9826	ARHGEF11	F007	Human	Colorectum	FAP	6.32e-03	-3.68e-01	0.1176
9826	ARHGEF11	A015-C-203	Human	Colorectum	FAP	1.21e-22	-3.83e-01	-0.1294
9826	ARHGEF11	A015-C-204	Human	Colorectum	FAP	4.72e-09	-3.31e-01	-0.0228
9826	ARHGEF11	A014-C-040	Human	Colorectum	FAP	8.07e-03	-3.42e-01	-0.1184
9826	ARHGEF11	A002-C-201	Human	Colorectum	FAP	5.02e-11	-3.03e-01	0.0324
9826	ARHGEF11	A001-C-119	Human	Colorectum	FAP	6.79e-06	-4.28e-01	-0.1557
9826	ARHGEF11	A001-C-108	Human	Colorectum	FAP	9.91e-15	-3.10e-01	-0.0272
9826	ARHGEF11	A002-C-205	Human	Colorectum	FAP	4.79e-19	-4.55e-01	-0.1236
9826	ARHGEF11	A015-C-005	Human	Colorectum	FAP	2.89e-02	-1.43e-01	-0.0336
9826	ARHGEF11	A015-C-006	Human	Colorectum	FAP	3.47e-11	-3.47e-01	-0.0994
9826	ARHGEF11	A015-C-106	Human	Colorectum	FAP	3.38e-09	-2.26e-01	-0.0511
9826	ARHGEF11	A002-C-114	Human	Colorectum	FAP	5.98e-16	-4.25e-01	-0.1561
9826	ARHGEF11	A015-C-104	Human	Colorectum	FAP	1.44e-22	-3.76e-01	-0.1899
9826	ARHGEF11	A001-C-014	Human	Colorectum	FAP	2.59e-13	-3.18e-01	0.0135
9826	ARHGEF11	A002-C-016	Human	Colorectum	FAP	2.04e-18	-3.41e-01	0.0521

Page: 1 2

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00071639	Cervix	CC	establishment or maintenance of cell polarity	63/2311	218/18723	4.25e-11	8.76e-09	63
GO:00510566	Cervix	CC	regulation of small GTPase mediated signal transduction	75/2311	302/18723	1.54e-09	1.74e-07	75
GO:00072656	Cervix	CC	Ras protein signal transduction	79/2311	337/18723	9.49e-09	7.77e-07	79
GO:00300108	Cervix	CC	establishment of cell polarity	42/2311	143/18723	4.30e-08	2.62e-06	42
GO:00160498	Cervix	CC	cell growth	92/2311	482/18723	1.16e-05	2.49e-04	92
GO:00072666	Cervix	CC	Rho protein signal transduction	35/2311	137/18723	1.77e-05	3.33e-04	35
GO:00015588	Cervix	CC	regulation of cell growth	77/2311	414/18723	1.40e-04	1.70e-03	77
GO:0007163	Colorectum	AD	establishment or maintenance of cell polarity	77/3918	218/18723	5.72e-07	2.08e-05	77
GO:0016049	Colorectum	AD	cell growth	143/3918	482/18723	2.83e-06	8.09e-05	143
GO:0001558	Colorectum	AD	regulation of cell growth	124/3918	414/18723	7.67e-06	1.86e-04	124
GO:0007265	Colorectum	AD	Ras protein signal transduction	104/3918	337/18723	1.01e-05	2.35e-04	104
GO:0051056	Colorectum	AD	regulation of small GTPase mediated signal transduction	94/3918	302/18723	1.81e-05	3.76e-04	94
GO:0030010	Colorectum	AD	establishment of cell polarity	50/3918	143/18723	6.90e-05	1.11e-03	50
GO:0007266	Colorectum	AD	Rho protein signal transduction	42/3918	137/18723	4.64e-03	3.16e-02	42
GO:00071632	Colorectum	MSS	establishment or maintenance of cell polarity	72/3467	218/18723	1.90e-07	8.30e-06	72
GO:00300102	Colorectum	MSS	establishment of cell polarity	47/3467	143/18723	2.74e-05	5.58e-04	47
GO:00160492	Colorectum	MSS	cell growth	123/3467	482/18723	7.15e-05	1.21e-03	123
GO:00072651	Colorectum	MSS	Ras protein signal transduction	91/3467	337/18723	7.20e-05	1.21e-03	91
GO:00510561	Colorectum	MSS	regulation of small GTPase mediated signal transduction	82/3467	302/18723	1.31e-04	1.99e-03	82
GO:00015582	Colorectum	MSS	regulation of cell growth	105/3467	414/18723	2.97e-04	3.90e-03	105

Page: 1 2 3

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0513020	Cervix	CC	Pathogenic Escherichia coli infection	63/1267	197/8465	9.28e-10	2.00e-08	1.19e-08	63
hsa0516318	Cervix	CC	Human cytomegalovirus infection	65/1267	225/8465	4.59e-08	6.47e-07	3.83e-07	65
hsa0492812	Cervix	CC	Parathyroid hormone synthesis, secretion and action	27/1267	106/8465	3.12e-03	1.19e-02	7.03e-03	27
hsa05130110	Cervix	CC	Pathogenic Escherichia coli infection	63/1267	197/8465	9.28e-10	2.00e-08	1.19e-08	63
hsa0516319	Cervix	CC	Human cytomegalovirus infection	65/1267	225/8465	4.59e-08	6.47e-07	3.83e-07	65
hsa0492813	Cervix	CC	Parathyroid hormone synthesis, secretion and action	27/1267	106/8465	3.12e-03	1.19e-02	7.03e-03	27
hsa05130	Colorectum	AD	Pathogenic Escherichia coli infection	79/2092	197/8465	1.05e-06	1.36e-05	8.65e-06	79
hsa05163	Colorectum	AD	Human cytomegalovirus infection	75/2092	225/8465	2.00e-03	1.10e-02	7.01e-03	75
hsa04928	Colorectum	AD	Parathyroid hormone synthesis, secretion and action	38/2092	106/8465	6.60e-03	2.77e-02	1.76e-02	38
hsa051301	Colorectum	AD	Pathogenic Escherichia coli infection	79/2092	197/8465	1.05e-06	1.36e-05	8.65e-06	79
hsa051631	Colorectum	AD	Human cytomegalovirus infection	75/2092	225/8465	2.00e-03	1.10e-02	7.01e-03	75
hsa049281	Colorectum	AD	Parathyroid hormone synthesis, secretion and action	38/2092	106/8465	6.60e-03	2.77e-02	1.76e-02	38
hsa051304	Colorectum	MSS	Pathogenic Escherichia coli infection	73/1875	197/8465	1.10e-06	1.48e-05	9.06e-06	73
hsa051634	Colorectum	MSS	Human cytomegalovirus infection	74/1875	225/8465	1.12e-04	1.01e-03	6.19e-04	74
hsa049284	Colorectum	MSS	Parathyroid hormone synthesis, secretion and action	37/1875	106/8465	1.72e-03	9.13e-03	5.59e-03	37
hsa051305	Colorectum	MSS	Pathogenic Escherichia coli infection	73/1875	197/8465	1.10e-06	1.48e-05	9.06e-06	73
hsa051635	Colorectum	MSS	Human cytomegalovirus infection	74/1875	225/8465	1.12e-04	1.01e-03	6.19e-04	74
hsa049285	Colorectum	MSS	Parathyroid hormone synthesis, secretion and action	37/1875	106/8465	1.72e-03	9.13e-03	5.59e-03	37
hsa051308	Colorectum	FAP	Pathogenic Escherichia coli infection	62/1404	197/8465	1.37e-07	3.08e-06	1.87e-06	62
hsa051636	Colorectum	FAP	Human cytomegalovirus infection	55/1404	225/8465	1.42e-03	7.67e-03	4.67e-03	55

Page: 1 2

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

ARHGEF11

SNV

Missense_Mutation

c.2701N>A

p.Glu901Lys

p.E901K

O15085

protein_coding

deleterious(0)

probably_damaging(0.998)

TCGA-5L-AAT1-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Hormone Therapy

letrozol

ARHGEF11

SNV

Missense_Mutation

c.1036G>C

p.Glu346Gln

p.E346Q

O15085

protein_coding

tolerated(0.12)

probably_damaging(0.91)

TCGA-A2-A0CL-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

cytoxan

ARHGEF11

SNV

Missense_Mutation

novel

c.1351G>C

p.Glu451Gln

p.E451Q

O15085

protein_coding

deleterious(0.01)

benign(0.014)

TCGA-A2-A0EP-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cyclophosphamide

ARHGEF11

SNV

Missense_Mutation

c.3710N>A

p.Leu1237His

p.L1237H

O15085

protein_coding

deleterious_low_confidence(0)

probably_damaging(0.999)

TCGA-A8-A085-01

Breast

breast invasive carcinoma

Male

<65

I/II

Hormone Therapy

tamoxiphen

ARHGEF11

SNV

Missense_Mutation

novel

c.3034N>G

p.Leu1012Val

p.L1012V

O15085

protein_coding

deleterious(0.02)

probably_damaging(0.957)

TCGA-AC-A2BK-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

cytoxan

ARHGEF11

SNV

Missense_Mutation

novel

c.1942C>T

p.Arg648Cys

p.R648C

O15085

protein_coding

deleterious(0)

probably_damaging(0.97)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

ARHGEF11

SNV

Missense_Mutation

c.1288N>T

p.Arg430Cys

p.R430C

O15085

protein_coding

deleterious(0.01)

possibly_damaging(0.892)

TCGA-AN-A0AK-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

ARHGEF11

SNV

Missense_Mutation

c.1288N>T

p.Arg430Cys

p.R430C

O15085

protein_coding

deleterious(0.01)

possibly_damaging(0.892)

TCGA-AO-A128-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

ARHGEF11

SNV

Missense_Mutation

c.2923G>T

p.Gly975Cys

p.G975C

O15085

protein_coding

deleterious(0.01)

possibly_damaging(0.558)

TCGA-AR-A24H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

tamoxiphen

ARHGEF11

SNV

Missense_Mutation

c.2922G>C

p.Glu974Asp

p.E974D

O15085

protein_coding

tolerated(0.06)

benign(0.25)

TCGA-AR-A24H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

tamoxiphen

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1