Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: ARHGAP5

Gene summary for ARHGAP5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ARHGAP5

Gene ID

394

Gene nameRho GTPase activating protein 5
Gene AliasGFI2
Cytomap14q12
Gene Typeprotein-coding
GO ID

GO:0007154

UniProtAcc

Q13017


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
394ARHGAP5CA_HPV_1HumanCervixCC1.72e-05-2.16e-010.0264
394ARHGAP5CA_HPV_3HumanCervixCC9.88e-041.61e-010.0414
394ARHGAP5CCI_1HumanCervixCC3.93e-036.64e-010.528
394ARHGAP5CCI_2HumanCervixCC3.54e-131.37e+000.5249
394ARHGAP5CCI_3HumanCervixCC5.24e-037.03e-010.516
394ARHGAP5T3HumanCervixCC5.79e-031.76e-010.1389
394ARHGAP5HTA11_3410_2000001011HumanColorectumAD2.45e-31-8.38e-010.0155
394ARHGAP5HTA11_2487_2000001011HumanColorectumSER1.66e-08-5.64e-01-0.1808
394ARHGAP5HTA11_1938_2000001011HumanColorectumAD6.52e-05-4.80e-01-0.0811
394ARHGAP5HTA11_3361_2000001011HumanColorectumAD2.18e-07-6.67e-01-0.1207
394ARHGAP5HTA11_83_2000001011HumanColorectumSER1.47e-05-5.90e-01-0.1526
394ARHGAP5HTA11_696_2000001011HumanColorectumAD3.09e-14-5.56e-01-0.1464
394ARHGAP5HTA11_866_2000001011HumanColorectumAD7.88e-11-5.15e-01-0.1001
394ARHGAP5HTA11_1391_2000001011HumanColorectumAD3.29e-02-4.34e-01-0.059
394ARHGAP5HTA11_5212_2000001011HumanColorectumAD1.06e-03-6.96e-01-0.2061
394ARHGAP5HTA11_7862_2000001011HumanColorectumAD5.75e-05-7.27e-01-0.0179
394ARHGAP5HTA11_866_3004761011HumanColorectumAD9.19e-14-6.47e-010.096
394ARHGAP5HTA11_4255_2000001011HumanColorectumSER1.50e-02-6.61e-010.0446
394ARHGAP5HTA11_8622_2000001021HumanColorectumSER9.46e-05-7.71e-010.0528
394ARHGAP5HTA11_10711_2000001011HumanColorectumAD1.82e-06-5.45e-010.0338
Page: 1 2 3 4 5 6 7 8 9 10 11 12 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00510566CervixCCregulation of small GTPase mediated signal transduction75/2311302/187231.54e-091.74e-0775
GO:00072656CervixCCRas protein signal transduction79/2311337/187239.49e-097.77e-0779
GO:00072666CervixCCRho protein signal transduction35/2311137/187231.77e-053.33e-0435
GO:004873210CervixCCgland development84/2311436/187231.93e-053.54e-0484
GO:00308797CervixCCmammary gland development28/2311137/187234.74e-032.83e-0228
GO:0048732ColorectumADgland development149/3918436/187236.07e-116.33e-09149
GO:0030879ColorectumADmammary gland development53/3918137/187231.46e-064.58e-0553
GO:0007265ColorectumADRas protein signal transduction104/3918337/187231.01e-052.35e-04104
GO:0051056ColorectumADregulation of small GTPase mediated signal transduction94/3918302/187231.81e-053.76e-0494
GO:0007266ColorectumADRho protein signal transduction42/3918137/187234.64e-033.16e-0242
GO:00487321ColorectumSERgland development112/2897436/187231.75e-081.28e-06112
GO:00308791ColorectumSERmammary gland development37/2897137/187233.61e-045.61e-0337
GO:00487322ColorectumMSSgland development143/3467436/187233.85e-138.01e-11143
GO:00308792ColorectumMSSmammary gland development51/3467137/187231.88e-078.26e-0651
GO:00072651ColorectumMSSRas protein signal transduction91/3467337/187237.20e-051.21e-0391
GO:00510561ColorectumMSSregulation of small GTPase mediated signal transduction82/3467302/187231.31e-041.99e-0382
GO:00510562ColorectumFAPregulation of small GTPase mediated signal transduction78/2622302/187233.25e-082.85e-0678
GO:00487324ColorectumFAPgland development103/2622436/187233.61e-083.12e-06103
GO:00072652ColorectumFAPRas protein signal transduction80/2622337/187239.61e-074.33e-0580
GO:00072661ColorectumFAPRho protein signal transduction34/2622137/187235.11e-045.82e-0334
Page: 1 2 3 4 5 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0451010CervixCCFocal adhesion59/1267203/84651.53e-071.84e-061.09e-0659
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0451014CervixCCFocal adhesion59/1267203/84651.53e-071.84e-061.09e-0659
hsa04670110CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa04510ColorectumADFocal adhesion67/2092203/84654.40e-032.17e-021.38e-0267
hsa04670ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
hsa045101ColorectumADFocal adhesion67/2092203/84654.40e-032.17e-021.38e-0267
hsa046701ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
hsa046702ColorectumSERLeukocyte transendothelial migration37/1580114/84652.77e-042.56e-031.86e-0337
hsa046703ColorectumSERLeukocyte transendothelial migration37/1580114/84652.77e-042.56e-031.86e-0337
hsa046704ColorectumMSSLeukocyte transendothelial migration36/1875114/84651.21e-024.02e-022.46e-0236
hsa046705ColorectumMSSLeukocyte transendothelial migration36/1875114/84651.21e-024.02e-022.46e-0236
hsa045102ColorectumFAPFocal adhesion61/1404203/84651.03e-062.15e-051.31e-0561
hsa046706ColorectumFAPLeukocyte transendothelial migration37/1404114/84652.12e-052.53e-041.54e-0437
hsa045103ColorectumFAPFocal adhesion61/1404203/84651.03e-062.15e-051.31e-0561
hsa046707ColorectumFAPLeukocyte transendothelial migration37/1404114/84652.12e-052.53e-041.54e-0437
hsa045104ColorectumCRCFocal adhesion51/1091203/84651.29e-065.41e-053.66e-0551
hsa046708ColorectumCRCLeukocyte transendothelial migration25/1091114/84654.82e-032.66e-021.80e-0225
hsa045105ColorectumCRCFocal adhesion51/1091203/84651.29e-065.41e-053.66e-0551
hsa046709ColorectumCRCLeukocyte transendothelial migration25/1091114/84654.82e-032.66e-021.80e-0225
Page: 1 2 3 4 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ARHGAP5SNVMissense_Mutationc.1547G>Ap.Ser516Asnp.S516NQ13017protein_codingdeleterious(0.01)possibly_damaging(0.9)TCGA-A1-A0SF-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytcSD
ARHGAP5SNVMissense_Mutationc.1652A>Gp.His551Argp.H551RQ13017protein_codingdeleterious(0.01)probably_damaging(0.987)TCGA-A2-A0D2-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
ARHGAP5SNVMissense_Mutationnovelc.2290N>Cp.Val764Leup.V764LQ13017protein_codingtolerated(0.91)benign(0.001)TCGA-A7-A4SE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
ARHGAP5SNVMissense_Mutationc.272A>Tp.His91Leup.H91LQ13017protein_codingdeleterious(0.01)possibly_damaging(0.669)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP5SNVMissense_Mutationrs78337553c.1465G>Ap.Glu489Lysp.E489KQ13017protein_codingdeleterious(0.01)possibly_damaging(0.689)TCGA-AC-A23G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanCR
ARHGAP5SNVMissense_Mutationrs747803256c.2545N>Ap.His849Asnp.H849NQ13017protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP5SNVMissense_Mutationnovelc.4046N>Ap.Ser1349Tyrp.S1349YQ13017protein_codingdeleterious(0.02)possibly_damaging(0.905)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP5SNVMissense_Mutationrs759492227c.3787N>Tp.Pro1263Serp.P1263SQ13017protein_codingdeleterious(0.01)possibly_damaging(0.718)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
ARHGAP5SNVMissense_Mutationc.882T>Ap.Ser294Argp.S294RQ13017protein_codingtolerated(0.14)possibly_damaging(0.709)TCGA-B6-A0RU-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
ARHGAP5SNVMissense_Mutationrs78337553c.1465G>Ap.Glu489Lysp.E489KQ13017protein_codingdeleterious(0.01)possibly_damaging(0.689)TCGA-BH-A0W7-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1