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Gene: ARHGAP31 |
Gene summary for ARHGAP31 |
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Gene information | Species | Human | Gene symbol | ARHGAP31 | Gene ID | 57514 |
Gene name | Rho GTPase activating protein 31 | |
Gene Alias | AOS1 | |
Cytomap | 3q13.32-q13.33 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q2M1Z3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57514 | ARHGAP31 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.55e-07 | 3.66e-01 | -0.1088 |
57514 | ARHGAP31 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.34e-05 | 4.09e-01 | -0.1207 |
57514 | ARHGAP31 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.07e-04 | 2.72e-01 | -0.1464 |
57514 | ARHGAP31 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 4.79e-02 | 7.04e-01 | -0.028 |
57514 | ARHGAP31 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.45e-18 | 8.22e-01 | -0.2116 |
57514 | ARHGAP31 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 6.27e-03 | 4.62e-01 | -0.1941 |
57514 | ARHGAP31 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 3.46e-07 | 6.96e-01 | -0.2107 |
57514 | ARHGAP31 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.08e-11 | 5.88e-01 | -0.2119 |
57514 | ARHGAP31 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 9.08e-19 | 6.58e-01 | -0.0166 |
57514 | ARHGAP31 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.21e-18 | 5.72e-01 | -0.0132 |
57514 | ARHGAP31 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.55e-23 | 6.20e-01 | -0.013 |
57514 | ARHGAP31 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.82e-15 | 5.38e-01 | -0.0121 |
57514 | ARHGAP31 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 4.16e-03 | 4.30e-01 | -0.0961 |
57514 | ARHGAP31 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 3.62e-04 | 5.10e-01 | -0.0876 |
57514 | ARHGAP31 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 7.62e-03 | 4.45e-01 | -0.0822 |
57514 | ARHGAP31 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.46e-05 | 4.55e-01 | -0.0809 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:005105611 | Lung | AIS | regulation of small GTPase mediated signal transduction | 66/1849 | 302/18723 | 4.26e-10 | 9.53e-08 | 66 |
GO:005105621 | Lung | MIAC | regulation of small GTPase mediated signal transduction | 35/967 | 302/18723 | 6.81e-06 | 6.35e-04 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP31 | SNV | Missense_Mutation | novel | c.1258C>A | p.Leu420Ile | p.L420I | Q2M1Z3 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ARHGAP31 | SNV | Missense_Mutation | c.1070N>A | p.Gly357Glu | p.G357E | Q2M1Z3 | protein_coding | deleterious(0.04) | benign(0.369) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
ARHGAP31 | SNV | Missense_Mutation | c.2348N>G | p.Pro783Arg | p.P783R | Q2M1Z3 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
ARHGAP31 | SNV | Missense_Mutation | rs771980065 | c.2777N>T | p.Ala926Val | p.A926V | Q2M1Z3 | protein_coding | tolerated(1) | benign(0) | TCGA-A2-A0CW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ARHGAP31 | SNV | Missense_Mutation | c.3524N>A | p.Arg1175His | p.R1175H | Q2M1Z3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
ARHGAP31 | SNV | Missense_Mutation | rs763998234 | c.2426N>T | p.Ser809Leu | p.S809L | Q2M1Z3 | protein_coding | tolerated(0.21) | benign(0) | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR |
ARHGAP31 | SNV | Missense_Mutation | novel | c.235N>A | p.Leu79Met | p.L79M | Q2M1Z3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP31 | SNV | Missense_Mutation | c.3122C>A | p.Ala1041Glu | p.A1041E | Q2M1Z3 | protein_coding | tolerated(0.32) | benign(0.348) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP31 | SNV | Missense_Mutation | c.3979N>C | p.Glu1327Gln | p.E1327Q | Q2M1Z3 | protein_coding | tolerated(0.07) | possibly_damaging(0.879) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
ARHGAP31 | SNV | Missense_Mutation | c.3778N>A | p.Glu1260Lys | p.E1260K | Q2M1Z3 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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