Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: ARHGAP31

Gene summary for ARHGAP31

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ARHGAP31

Gene ID

57514

Gene nameRho GTPase activating protein 31
Gene AliasAOS1
Cytomap3q13.32-q13.33
Gene Typeprotein-coding
GO ID

GO:0007154

UniProtAcc

Q2M1Z3


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57514ARHGAP31HTA11_78_2000001011HumanColorectumAD8.55e-073.66e-01-0.1088
57514ARHGAP31HTA11_3361_2000001011HumanColorectumAD8.34e-054.09e-01-0.1207
57514ARHGAP31HTA11_696_2000001011HumanColorectumAD1.07e-042.72e-01-0.1464
57514ARHGAP31RNA-P23T2-P23T2-2HumanLungMIAC4.79e-027.04e-01-0.028
57514ARHGAP31RNA-P25T1-P25T1-1HumanLungAIS1.45e-188.22e-01-0.2116
57514ARHGAP31RNA-P25T1-P25T1-2HumanLungAIS6.27e-034.62e-01-0.1941
57514ARHGAP31RNA-P25T1-P25T1-3HumanLungAIS3.46e-076.96e-01-0.2107
57514ARHGAP31RNA-P25T1-P25T1-4HumanLungAIS5.08e-115.88e-01-0.2119
57514ARHGAP31RNA-P6T2-P6T2-1HumanLungIAC9.08e-196.58e-01-0.0166
57514ARHGAP31RNA-P6T2-P6T2-2HumanLungIAC1.21e-185.72e-01-0.0132
57514ARHGAP31RNA-P6T2-P6T2-3HumanLungIAC1.55e-236.20e-01-0.013
57514ARHGAP31RNA-P6T2-P6T2-4HumanLungIAC1.82e-155.38e-01-0.0121
57514ARHGAP31RNA-P7T1-P7T1-1HumanLungAIS4.16e-034.30e-01-0.0961
57514ARHGAP31RNA-P7T1-P7T1-2HumanLungAIS3.62e-045.10e-01-0.0876
57514ARHGAP31RNA-P7T1-P7T1-3HumanLungAIS7.62e-034.45e-01-0.0822
57514ARHGAP31RNA-P7T1-P7T1-4HumanLungAIS3.46e-054.55e-01-0.0809
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051056ColorectumADregulation of small GTPase mediated signal transduction94/3918302/187231.81e-053.76e-0494
GO:00510565LungIACregulation of small GTPase mediated signal transduction70/2061302/187239.44e-101.87e-0770
GO:005105611LungAISregulation of small GTPase mediated signal transduction66/1849302/187234.26e-109.53e-0866
GO:005105621LungMIACregulation of small GTPase mediated signal transduction35/967302/187236.81e-066.35e-0435
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ARHGAP31SNVMissense_Mutationnovelc.1258C>Ap.Leu420Ilep.L420IQ2M1Z3protein_codingtolerated(0.4)benign(0.001)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
ARHGAP31SNVMissense_Mutationc.1070N>Ap.Gly357Glup.G357EQ2M1Z3protein_codingdeleterious(0.04)benign(0.369)TCGA-A1-A0SH-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytcSD
ARHGAP31SNVMissense_Mutationc.2348N>Gp.Pro783Argp.P783RQ2M1Z3protein_codingdeleterious(0.01)possibly_damaging(0.881)TCGA-A1-A0SN-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyacSD
ARHGAP31SNVMissense_Mutationrs771980065c.2777N>Tp.Ala926Valp.A926VQ2M1Z3protein_codingtolerated(1)benign(0)TCGA-A2-A0CW-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
ARHGAP31SNVMissense_Mutationc.3524N>Ap.Arg1175Hisp.R1175HQ2M1Z3protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A2-A25B-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxoterePD
ARHGAP31SNVMissense_Mutationrs763998234c.2426N>Tp.Ser809Leup.S809LQ2M1Z3protein_codingtolerated(0.21)benign(0)TCGA-A8-A0A6-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyepirubicinCR
ARHGAP31SNVMissense_Mutationnovelc.235N>Ap.Leu79Metp.L79MQ2M1Z3protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ARHGAP31SNVMissense_Mutationc.3122C>Ap.Ala1041Glup.A1041EQ2M1Z3protein_codingtolerated(0.32)benign(0.348)TCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ARHGAP31SNVMissense_Mutationc.3979N>Cp.Glu1327Glnp.E1327QQ2M1Z3protein_codingtolerated(0.07)possibly_damaging(0.879)TCGA-BH-A0DZ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydocetaxelSD
ARHGAP31SNVMissense_Mutationc.3778N>Ap.Glu1260Lysp.E1260KQ2M1Z3protein_codingtolerated(0.14)benign(0.006)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1