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Gene: ARHGAP11B |
Gene summary for ARHGAP11B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ARHGAP11B | Gene ID | 89839 |
| Gene name | Rho GTPase activating protein 11B | |
| Gene Alias | B'-T | |
| Cytomap | 15q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q3KRB8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 89839 | ARHGAP11B | ATC12 | Human | Thyroid | ATC | 1.15e-03 | 1.17e-01 | 0.34 |
| 89839 | ARHGAP11B | ATC2 | Human | Thyroid | ATC | 5.90e-10 | 9.49e-01 | 0.34 |
| 89839 | ARHGAP11B | ATC4 | Human | Thyroid | ATC | 6.21e-03 | 1.11e-01 | 0.34 |
| 89839 | ARHGAP11B | ATC5 | Human | Thyroid | ATC | 2.29e-02 | 8.27e-02 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000683929 | Thyroid | ATC | mitochondrial transport | 151/6293 | 254/18723 | 2.07e-17 | 2.14e-15 | 151 |
| GO:0007006111 | Thyroid | ATC | mitochondrial membrane organization | 69/6293 | 116/18723 | 9.55e-09 | 2.00e-07 | 69 |
| GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
| GO:003090015 | Thyroid | ATC | forebrain development | 164/6293 | 379/18723 | 4.85e-05 | 3.87e-04 | 164 |
| GO:002153712 | Thyroid | ATC | telencephalon development | 113/6293 | 248/18723 | 5.61e-05 | 4.32e-04 | 113 |
| GO:002154312 | Thyroid | ATC | pallium development | 81/6293 | 169/18723 | 7.67e-05 | 5.80e-04 | 81 |
| GO:0046902110 | Thyroid | ATC | regulation of mitochondrial membrane permeability | 36/6293 | 63/18723 | 1.05e-04 | 7.55e-04 | 36 |
| GO:009055919 | Thyroid | ATC | regulation of membrane permeability | 42/6293 | 78/18723 | 1.82e-04 | 1.23e-03 | 42 |
| GO:002198722 | Thyroid | ATC | cerebral cortex development | 55/6293 | 114/18723 | 8.32e-04 | 4.57e-03 | 55 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ARHGAP11B | SNV | Missense_Mutation | rs759843396 | c.353N>T | p.Ala118Val | p.A118V | Q3KRB8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ARHGAP11B | SNV | Missense_Mutation | rs567608269 | c.260N>A | p.Arg87Gln | p.R87Q | Q3KRB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ARHGAP11B | SNV | Missense_Mutation | rs770792015 | c.715N>A | p.Val239Ile | p.V239I | Q3KRB8 | protein_coding | tolerated_low_confidence(0.28) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ARHGAP11B | SNV | Missense_Mutation | novel | c.765A>C | p.Lys255Asn | p.K255N | Q3KRB8 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ARHGAP11B | SNV | Missense_Mutation | novel | c.689N>A | p.Arg230Lys | p.R230K | Q3KRB8 | protein_coding | tolerated_low_confidence(0.11) | benign(0.001) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ARHGAP11B | SNV | Missense_Mutation | novel | c.24N>T | p.Lys8Asn | p.K8N | Q3KRB8 | protein_coding | deleterious(0) | benign(0.099) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ARHGAP11B | SNV | Missense_Mutation | c.456N>T | p.Lys152Asn | p.K152N | Q3KRB8 | protein_coding | deleterious(0.03) | possibly_damaging(0.735) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ARHGAP11B | SNV | Missense_Mutation | novel | c.640N>C | p.Ser214Pro | p.S214P | Q3KRB8 | protein_coding | deleterious(0.01) | probably_damaging(0.931) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
| ARHGAP11B | SNV | Missense_Mutation | c.456N>T | p.Lys152Asn | p.K152N | Q3KRB8 | protein_coding | deleterious(0.03) | possibly_damaging(0.735) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ARHGAP11B | SNV | Missense_Mutation | c.422N>C | p.Leu141Pro | p.L141P | Q3KRB8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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