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Gene: APOL4 |
Gene summary for APOL4 |
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Gene information | Species | Human | Gene symbol | APOL4 | Gene ID | 80832 |
Gene name | apolipoprotein L4 | |
Gene Alias | APOL-IV | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9BPW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80832 | APOL4 | HCC1 | Human | Liver | HCC | 1.89e-02 | 2.20e+00 | 0.5336 |
80832 | APOL4 | HCC2 | Human | Liver | HCC | 1.21e-05 | 1.47e+00 | 0.5341 |
80832 | APOL4 | S014 | Human | Liver | HCC | 2.64e-07 | 2.99e-01 | 0.2254 |
80832 | APOL4 | S015 | Human | Liver | HCC | 9.93e-07 | 2.32e-01 | 0.2375 |
80832 | APOL4 | S016 | Human | Liver | HCC | 3.39e-02 | 1.29e-01 | 0.2243 |
80832 | APOL4 | S029 | Human | Liver | HCC | 8.89e-06 | 2.57e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421571 | Liver | HCC | lipoprotein metabolic process | 86/7958 | 135/18723 | 5.21e-07 | 8.38e-06 | 86 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOL4 | SNV | Missense_Mutation | rs774986936 | c.428C>A | p.Ala143Asp | p.A143D | Q9BPW4 | protein_coding | deleterious(0.01) | possibly_damaging(0.587) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | c.466N>G | p.Ile156Val | p.I156V | Q9BPW4 | protein_coding | tolerated(0.39) | benign(0) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APOL4 | SNV | Missense_Mutation | rs746034036 | c.562N>A | p.Ala188Thr | p.A188T | Q9BPW4 | protein_coding | tolerated(1) | benign(0.018) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | novel | c.251N>G | p.Lys84Arg | p.K84R | Q9BPW4 | protein_coding | tolerated(0.38) | benign(0.382) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | rs373611761 | c.574N>A | p.Val192Met | p.V192M | Q9BPW4 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
APOL4 | SNV | Missense_Mutation | c.376N>T | p.Leu126Phe | p.L126F | Q9BPW4 | protein_coding | deleterious(0.01) | benign(0.355) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APOL4 | SNV | Missense_Mutation | c.810N>A | p.Asn270Lys | p.N270K | Q9BPW4 | protein_coding | tolerated(0.9) | benign(0.034) | TCGA-AF-6672-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Ancillary | leucovorin | PD | |
APOL4 | SNV | Missense_Mutation | novel | c.746C>T | p.Thr249Ile | p.T249I | Q9BPW4 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | novel | c.493G>A | p.Ala165Thr | p.A165T | Q9BPW4 | protein_coding | tolerated(0.09) | possibly_damaging(0.66) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | c.962N>A | p.Ser321Tyr | p.S321Y | Q9BPW4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A5-A0GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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