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Gene: API5 |
Gene summary for API5 |
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Gene information | Species | Human | Gene symbol | API5 | Gene ID | 8539 |
Gene name | apoptosis inhibitor 5 | |
Gene Alias | AAC-11 | |
Cytomap | 11p12 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9BZZ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8539 | API5 | LZE4T | Human | Esophagus | ESCC | 2.06e-16 | 5.15e-01 | 0.0811 |
8539 | API5 | LZE7T | Human | Esophagus | ESCC | 4.25e-09 | 6.59e-01 | 0.0667 |
8539 | API5 | LZE8T | Human | Esophagus | ESCC | 6.37e-06 | 3.46e-01 | 0.067 |
8539 | API5 | LZE20T | Human | Esophagus | ESCC | 4.37e-09 | 1.66e-01 | 0.0662 |
8539 | API5 | LZE22T | Human | Esophagus | ESCC | 1.29e-02 | 1.07e-01 | 0.068 |
8539 | API5 | LZE24T | Human | Esophagus | ESCC | 1.01e-21 | 5.93e-01 | 0.0596 |
8539 | API5 | LZE21T | Human | Esophagus | ESCC | 1.12e-02 | 2.06e-01 | 0.0655 |
8539 | API5 | LZE6T | Human | Esophagus | ESCC | 4.05e-09 | 3.22e-01 | 0.0845 |
8539 | API5 | P2T-E | Human | Esophagus | ESCC | 8.61e-42 | 7.08e-01 | 0.1177 |
8539 | API5 | P4T-E | Human | Esophagus | ESCC | 1.06e-14 | 3.98e-01 | 0.1323 |
8539 | API5 | P5T-E | Human | Esophagus | ESCC | 9.25e-13 | 1.78e-01 | 0.1327 |
8539 | API5 | P8T-E | Human | Esophagus | ESCC | 6.10e-29 | 6.08e-01 | 0.0889 |
8539 | API5 | P9T-E | Human | Esophagus | ESCC | 4.62e-18 | 3.64e-01 | 0.1131 |
8539 | API5 | P10T-E | Human | Esophagus | ESCC | 5.95e-31 | 5.39e-01 | 0.116 |
8539 | API5 | P11T-E | Human | Esophagus | ESCC | 1.89e-22 | 7.78e-01 | 0.1426 |
8539 | API5 | P12T-E | Human | Esophagus | ESCC | 6.27e-28 | 4.98e-01 | 0.1122 |
8539 | API5 | P15T-E | Human | Esophagus | ESCC | 2.73e-31 | 6.22e-01 | 0.1149 |
8539 | API5 | P16T-E | Human | Esophagus | ESCC | 5.81e-33 | 5.54e-01 | 0.1153 |
8539 | API5 | P17T-E | Human | Esophagus | ESCC | 8.37e-13 | 5.65e-01 | 0.1278 |
8539 | API5 | P19T-E | Human | Esophagus | ESCC | 1.69e-11 | 6.97e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00443463 | Esophagus | ESCC | fibroblast apoptotic process | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:0044346 | Oral cavity | OSCC | fibroblast apoptotic process | 16/7305 | 22/18723 | 1.40e-03 | 6.79e-03 | 16 |
GO:2000269 | Oral cavity | OSCC | regulation of fibroblast apoptotic process | 13/7305 | 19/18723 | 9.07e-03 | 3.26e-02 | 13 |
GO:00443461 | Oral cavity | LP | fibroblast apoptotic process | 13/4623 | 22/18723 | 6.11e-04 | 5.58e-03 | 13 |
GO:20002691 | Oral cavity | LP | regulation of fibroblast apoptotic process | 10/4623 | 19/18723 | 8.09e-03 | 4.40e-02 | 10 |
GO:00443464 | Skin | AK | fibroblast apoptotic process | 8/1910 | 22/18723 | 9.95e-04 | 7.87e-03 | 8 |
GO:20002692 | Skin | AK | regulation of fibroblast apoptotic process | 6/1910 | 19/18723 | 9.42e-03 | 4.60e-02 | 6 |
GO:004434611 | Skin | cSCC | fibroblast apoptotic process | 12/4864 | 22/18723 | 4.04e-03 | 2.15e-02 | 12 |
GO:00443465 | Thyroid | PTC | fibroblast apoptotic process | 13/5968 | 22/18723 | 7.65e-03 | 3.25e-02 | 13 |
GO:004434612 | Thyroid | ATC | fibroblast apoptotic process | 16/6293 | 22/18723 | 2.03e-04 | 1.35e-03 | 16 |
GO:20002693 | Thyroid | ATC | regulation of fibroblast apoptotic process | 13/6293 | 19/18723 | 2.03e-03 | 9.63e-03 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
API5 | SNV | Missense_Mutation | novel | c.1267N>T | p.Val423Phe | p.V423F | Q9BZZ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.856) | TCGA-AC-A2QJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
API5 | SNV | Missense_Mutation | c.1275N>G | p.Ile425Met | p.I425M | Q9BZZ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AR-A0TW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD | |
API5 | SNV | Missense_Mutation | c.223G>C | p.Asp75His | p.D75H | Q9BZZ5 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-B6-A0I2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
API5 | SNV | Missense_Mutation | novel | c.861N>C | p.Leu287Phe | p.L287F | Q9BZZ5 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
API5 | SNV | Missense_Mutation | novel | c.706G>C | p.Asp236His | p.D236H | Q9BZZ5 | protein_coding | tolerated(0.06) | probably_damaging(0.989) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
API5 | SNV | Missense_Mutation | c.1102N>A | p.Glu368Lys | p.E368K | Q9BZZ5 | protein_coding | deleterious(0.05) | possibly_damaging(0.764) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
API5 | SNV | Missense_Mutation | rs745837171 | c.1196C>T | p.Thr399Met | p.T399M | Q9BZZ5 | protein_coding | deleterious(0.01) | possibly_damaging(0.782) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
API5 | SNV | Missense_Mutation | c.1536N>T | p.Trp512Cys | p.W512C | Q9BZZ5 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.941) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
API5 | SNV | Missense_Mutation | c.367N>C | p.Ser123Arg | p.S123R | Q9BZZ5 | protein_coding | deleterious(0.01) | possibly_damaging(0.856) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
API5 | SNV | Missense_Mutation | c.1174N>T | p.Arg392Cys | p.R392C | Q9BZZ5 | protein_coding | deleterious(0.02) | benign(0.096) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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