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Gene: APBB3 |
Gene summary for APBB3 |
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Gene information | Species | Human | Gene symbol | APBB3 | Gene ID | 10307 |
Gene name | amyloid beta precursor protein binding family B member 3 | |
Gene Alias | FE65L2 | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O95704 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10307 | APBB3 | HCC1_Meng | Human | Liver | HCC | 5.15e-03 | -1.12e-05 | 0.0246 |
10307 | APBB3 | HCC1 | Human | Liver | HCC | 1.84e-05 | 3.43e+00 | 0.5336 |
10307 | APBB3 | HCC2 | Human | Liver | HCC | 1.69e-03 | 3.37e+00 | 0.5341 |
10307 | APBB3 | S014 | Human | Liver | HCC | 3.70e-02 | 1.87e-01 | 0.2254 |
10307 | APBB3 | S016 | Human | Liver | HCC | 1.31e-06 | 2.43e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190495122 | Liver | HCC | positive regulation of establishment of protein localization | 207/7958 | 319/18723 | 3.95e-16 | 3.29e-14 | 207 |
GO:005122222 | Liver | HCC | positive regulation of protein transport | 194/7958 | 303/18723 | 2.41e-14 | 1.56e-12 | 194 |
GO:003559212 | Liver | HCC | establishment of protein localization to extracellular region | 176/7958 | 360/18723 | 7.96e-03 | 3.15e-02 | 176 |
GO:000930612 | Liver | HCC | protein secretion | 175/7958 | 359/18723 | 9.32e-03 | 3.57e-02 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APBB3 | SNV | Missense_Mutation | c.1243A>G | p.Met415Val | p.M415V | O95704 | protein_coding | tolerated(0.09) | probably_damaging(0.955) | TCGA-BH-A0W4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APBB3 | SNV | Missense_Mutation | novel | c.250G>A | p.Gly84Arg | p.G84R | O95704 | protein_coding | tolerated(0.44) | benign(0.026) | TCGA-GM-A3XN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
APBB3 | SNV | Missense_Mutation | rs529722873 | c.1396N>A | p.Gly466Ser | p.G466S | O95704 | protein_coding | tolerated(0.91) | possibly_damaging(0.609) | TCGA-OL-A5D6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APBB3 | SNV | Missense_Mutation | novel | c.1139N>A | p.Thr380Asn | p.T380N | O95704 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
APBB3 | SNV | Missense_Mutation | c.999N>T | p.Trp333Cys | p.W333C | O95704 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
APBB3 | SNV | Missense_Mutation | novel | c.538N>C | p.Ser180Arg | p.S180R | O95704 | protein_coding | tolerated(0.06) | probably_damaging(0.982) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APBB3 | SNV | Missense_Mutation | c.800A>T | p.Asp267Val | p.D267V | O95704 | protein_coding | tolerated(0.31) | benign(0.109) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
APBB3 | SNV | Missense_Mutation | rs760522044 | c.1342A>G | p.Met448Val | p.M448V | O95704 | protein_coding | tolerated(0.91) | benign(0) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
APBB3 | SNV | Missense_Mutation | c.8N>A | p.Gly3Asp | p.G3D | O95704 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
APBB3 | SNV | Missense_Mutation | c.1274C>A | p.Ser425Tyr | p.S425Y | O95704 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-D5-6932-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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