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Gene: APBB1IP |
Gene summary for APBB1IP |
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Gene information | Species | Human | Gene symbol | APBB1IP | Gene ID | 54518 |
Gene name | amyloid beta precursor protein binding family B member 1 interacting protein | |
Gene Alias | INAG1 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q7Z5R6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54518 | APBB1IP | NAFLD1 | Human | Liver | NAFLD | 3.28e-07 | 8.10e-01 | -0.04 |
54518 | APBB1IP | S43 | Human | Liver | Cirrhotic | 1.03e-07 | -1.64e-01 | -0.0187 |
54518 | APBB1IP | HCC1_Meng | Human | Liver | HCC | 2.21e-25 | -1.55e-01 | 0.0246 |
54518 | APBB1IP | HCC2_Meng | Human | Liver | HCC | 1.10e-06 | -2.25e-01 | 0.0107 |
54518 | APBB1IP | cirrhotic2 | Human | Liver | Cirrhotic | 6.60e-03 | -3.89e-02 | 0.0201 |
54518 | APBB1IP | HCC2 | Human | Liver | HCC | 8.56e-03 | 2.24e+00 | 0.5341 |
54518 | APBB1IP | S029 | Human | Liver | HCC | 2.56e-02 | 4.69e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457857 | Liver | Cirrhotic | positive regulation of cell adhesion | 141/4634 | 437/18723 | 2.05e-04 | 1.89e-03 | 141 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APBB1IP | SNV | Missense_Mutation | rs146489691 | c.33G>A | p.Met11Ile | p.M11I | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
APBB1IP | SNV | Missense_Mutation | c.1147G>A | p.Val383Ile | p.V383I | Q7Z5R6 | protein_coding | tolerated(0.08) | benign(0.395) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
APBB1IP | SNV | Missense_Mutation | novel | c.1021T>A | p.Tyr341Asn | p.Y341N | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.836N>A | p.Gly279Glu | p.G279E | Q7Z5R6 | protein_coding | deleterious(0.05) | benign(0.038) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.622T>C | p.Phe208Leu | p.F208L | Q7Z5R6 | protein_coding | tolerated(0.2) | probably_damaging(0.931) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
APBB1IP | SNV | Missense_Mutation | c.634N>G | p.His212Asp | p.H212D | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
APBB1IP | SNV | Missense_Mutation | novel | c.748N>C | p.Asp250His | p.D250H | Q7Z5R6 | protein_coding | tolerated(0.07) | possibly_damaging(0.474) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
APBB1IP | SNV | Missense_Mutation | novel | c.650N>C | p.Val217Ala | p.V217A | Q7Z5R6 | protein_coding | tolerated(0.1) | benign(0.339) | TCGA-DG-A2KJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
APBB1IP | SNV | Missense_Mutation | c.451N>A | p.Gln151Lys | p.Q151K | Q7Z5R6 | protein_coding | tolerated(0.46) | benign(0.001) | TCGA-FU-A3WB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
APBB1IP | SNV | Missense_Mutation | c.97C>T | p.Pro33Ser | p.P33S | Q7Z5R6 | protein_coding | tolerated(0.05) | benign(0.195) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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