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Gene: AP5M1 |
Gene summary for AP5M1 |
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Gene information | Species | Human | Gene symbol | AP5M1 | Gene ID | 55745 |
Gene name | adaptor related protein complex 5 subunit mu 1 | |
Gene Alias | C14orf108 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R654 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55745 | AP5M1 | LZE2T | Human | Esophagus | ESCC | 2.13e-02 | 4.08e-01 | 0.082 |
55745 | AP5M1 | LZE4T | Human | Esophagus | ESCC | 1.12e-08 | 2.41e-01 | 0.0811 |
55745 | AP5M1 | LZE5T | Human | Esophagus | ESCC | 6.44e-03 | 4.08e-01 | 0.0514 |
55745 | AP5M1 | LZE7T | Human | Esophagus | ESCC | 8.94e-07 | 2.09e-01 | 0.0667 |
55745 | AP5M1 | LZE8T | Human | Esophagus | ESCC | 3.21e-04 | 1.43e-01 | 0.067 |
55745 | AP5M1 | LZE24T | Human | Esophagus | ESCC | 6.07e-15 | 2.66e-01 | 0.0596 |
55745 | AP5M1 | LZE6T | Human | Esophagus | ESCC | 1.93e-02 | 1.14e-01 | 0.0845 |
55745 | AP5M1 | P1T-E | Human | Esophagus | ESCC | 3.25e-05 | 1.83e-01 | 0.0875 |
55745 | AP5M1 | P2T-E | Human | Esophagus | ESCC | 4.93e-18 | 1.99e-01 | 0.1177 |
55745 | AP5M1 | P4T-E | Human | Esophagus | ESCC | 6.43e-19 | 3.63e-01 | 0.1323 |
55745 | AP5M1 | P5T-E | Human | Esophagus | ESCC | 2.71e-07 | 7.57e-02 | 0.1327 |
55745 | AP5M1 | P8T-E | Human | Esophagus | ESCC | 9.14e-26 | 3.02e-01 | 0.0889 |
55745 | AP5M1 | P9T-E | Human | Esophagus | ESCC | 1.40e-11 | 1.18e-01 | 0.1131 |
55745 | AP5M1 | P10T-E | Human | Esophagus | ESCC | 4.37e-19 | 3.72e-01 | 0.116 |
55745 | AP5M1 | P11T-E | Human | Esophagus | ESCC | 1.94e-10 | 4.33e-01 | 0.1426 |
55745 | AP5M1 | P12T-E | Human | Esophagus | ESCC | 2.94e-26 | 5.00e-01 | 0.1122 |
55745 | AP5M1 | P15T-E | Human | Esophagus | ESCC | 2.28e-28 | 5.76e-01 | 0.1149 |
55745 | AP5M1 | P16T-E | Human | Esophagus | ESCC | 9.59e-09 | 2.06e-01 | 0.1153 |
55745 | AP5M1 | P17T-E | Human | Esophagus | ESCC | 2.25e-07 | 2.27e-01 | 0.1278 |
55745 | AP5M1 | P20T-E | Human | Esophagus | ESCC | 9.23e-24 | 3.00e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
GO:001619714 | Oral cavity | LP | endosomal transport | 98/4623 | 230/18723 | 1.65e-09 | 7.50e-08 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP5M1 | SNV | Missense_Mutation | novel | c.397N>C | p.Glu133Gln | p.E133Q | Q9H0R1 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AP5M1 | SNV | Missense_Mutation | novel | c.1096N>T | p.Ile366Phe | p.I366F | Q9H0R1 | protein_coding | deleterious(0) | possibly_damaging(0.858) | TCGA-E2-A14N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
AP5M1 | insertion | Frame_Shift_Ins | novel | c.243_244insAGACTCGCCCAACCTGAGGCTCCTGGCTCTC | p.Ser82ArgfsTer20 | p.S82Rfs*20 | Q9H0R1 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
AP5M1 | deletion | Frame_Shift_Del | novel | c.752delN | p.Ile252SerfsTer3 | p.I252Sfs*3 | Q9H0R1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
AP5M1 | SNV | Missense_Mutation | c.91N>A | p.Glu31Lys | p.E31K | Q9H0R1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AP5M1 | SNV | Missense_Mutation | c.151T>A | p.Phe51Ile | p.F51I | Q9H0R1 | protein_coding | tolerated(0.12) | benign(0.042) | TCGA-AA-3511-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
AP5M1 | SNV | Missense_Mutation | rs368987446 | c.403C>A | p.Leu135Ile | p.L135I | Q9H0R1 | protein_coding | deleterious(0.01) | benign(0.31) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AP5M1 | SNV | Missense_Mutation | c.818N>A | p.Thr273Asn | p.T273N | Q9H0R1 | protein_coding | tolerated(0.06) | probably_damaging(0.944) | TCGA-AG-3728-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
AP5M1 | SNV | Missense_Mutation | novel | c.69C>A | p.Phe23Leu | p.F23L | Q9H0R1 | protein_coding | deleterious(0.02) | benign(0.07) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AP5M1 | SNV | Missense_Mutation | novel | c.562N>C | p.Ser188Pro | p.S188P | Q9H0R1 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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