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Gene: AOPEP |
Gene summary for AOPEP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AOPEP | Gene ID | 84909 |
| Gene name | aminopeptidase O (putative) | |
| Gene Alias | AP-O | |
| Cytomap | 9q22.32 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8N6M6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84909 | AOPEP | CA_HPV_1 | Human | Cervix | CC | 2.47e-08 | -3.24e-01 | 0.0264 |
| 84909 | AOPEP | CA_HPV_3 | Human | Cervix | CC | 3.99e-17 | 5.10e-01 | 0.0414 |
| 84909 | AOPEP | N_HPV_2 | Human | Cervix | N_HPV | 1.78e-03 | 1.54e-01 | -0.0131 |
| 84909 | AOPEP | CCI_1 | Human | Cervix | CC | 1.65e-16 | 1.74e+00 | 0.528 |
| 84909 | AOPEP | CCI_2 | Human | Cervix | CC | 2.44e-24 | 3.78e+00 | 0.5249 |
| 84909 | AOPEP | CCI_3 | Human | Cervix | CC | 1.57e-44 | 3.21e+00 | 0.516 |
| 84909 | AOPEP | Tumor | Human | Cervix | CC | 3.12e-19 | -4.08e-01 | 0.1241 |
| 84909 | AOPEP | sample3 | Human | Cervix | CC | 3.28e-14 | 4.72e-01 | 0.1387 |
| 84909 | AOPEP | T3 | Human | Cervix | CC | 5.85e-17 | 5.04e-01 | 0.1389 |
| 84909 | AOPEP | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.95e-52 | 8.15e-01 | 0.0155 |
| 84909 | AOPEP | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.14e-31 | 6.98e-01 | -0.1808 |
| 84909 | AOPEP | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.39e-19 | 1.00e+00 | 0.0216 |
| 84909 | AOPEP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.21e-43 | 1.23e+00 | -0.0811 |
| 84909 | AOPEP | HTA11_78_2000001011 | Human | Colorectum | AD | 2.01e-50 | 1.07e+00 | -0.1088 |
| 84909 | AOPEP | HTA11_347_2000001011 | Human | Colorectum | AD | 1.07e-65 | 1.18e+00 | -0.1954 |
| 84909 | AOPEP | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-19 | 1.00e+00 | -0.2602 |
| 84909 | AOPEP | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.90e-09 | 5.07e-01 | -0.2196 |
| 84909 | AOPEP | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.31e-25 | 6.39e-01 | -0.1207 |
| 84909 | AOPEP | HTA11_83_2000001011 | Human | Colorectum | SER | 7.66e-30 | 9.36e-01 | -0.1526 |
| 84909 | AOPEP | HTA11_696_2000001011 | Human | Colorectum | AD | 4.48e-58 | 1.02e+00 | -0.1464 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 84909 | AOPEP | PROTEASE, DRUGGABLE GENOME | inhibitor | CHEMBL2103847 | TOSEDOSTAT |
| Page: 1 |
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