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Gene: ANXA8L1 |
Gene summary for ANXA8L1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ANXA8L1 | Gene ID | 728113 |
| Gene name | annexin A8 like 1 | |
| Gene Alias | ANXA8 | |
| Cytomap | 10q11.22 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P13928 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 728113 | ANXA8L1 | LZE4T | Human | Esophagus | ESCC | 3.59e-08 | 3.20e-01 | 0.0811 |
| 728113 | ANXA8L1 | LZE8T | Human | Esophagus | ESCC | 2.12e-20 | 6.74e-01 | 0.067 |
| 728113 | ANXA8L1 | LZE22D1 | Human | Esophagus | HGIN | 4.60e-05 | 2.67e-01 | 0.0595 |
| 728113 | ANXA8L1 | LZE22T | Human | Esophagus | ESCC | 3.80e-02 | 1.68e-01 | 0.068 |
| 728113 | ANXA8L1 | LZE24T | Human | Esophagus | ESCC | 6.01e-03 | 1.54e-01 | 0.0596 |
| 728113 | ANXA8L1 | LZE6T | Human | Esophagus | ESCC | 6.20e-08 | 3.59e-01 | 0.0845 |
| 728113 | ANXA8L1 | P1T-E | Human | Esophagus | ESCC | 1.14e-10 | 7.00e-01 | 0.0875 |
| 728113 | ANXA8L1 | P4T-E | Human | Esophagus | ESCC | 2.17e-12 | 2.73e-01 | 0.1323 |
| 728113 | ANXA8L1 | P5T-E | Human | Esophagus | ESCC | 8.30e-32 | 5.60e-01 | 0.1327 |
| 728113 | ANXA8L1 | P8T-E | Human | Esophagus | ESCC | 6.35e-12 | 3.41e-01 | 0.0889 |
| 728113 | ANXA8L1 | P11T-E | Human | Esophagus | ESCC | 1.83e-25 | 1.94e+00 | 0.1426 |
| 728113 | ANXA8L1 | P17T-E | Human | Esophagus | ESCC | 7.18e-18 | 9.48e-01 | 0.1278 |
| 728113 | ANXA8L1 | P19T-E | Human | Esophagus | ESCC | 2.56e-06 | 8.75e-01 | 0.1662 |
| 728113 | ANXA8L1 | P20T-E | Human | Esophagus | ESCC | 5.77e-28 | 7.40e-01 | 0.1124 |
| 728113 | ANXA8L1 | P21T-E | Human | Esophagus | ESCC | 2.37e-61 | 1.41e+00 | 0.1617 |
| 728113 | ANXA8L1 | P22T-E | Human | Esophagus | ESCC | 1.45e-13 | 2.97e-01 | 0.1236 |
| 728113 | ANXA8L1 | P23T-E | Human | Esophagus | ESCC | 1.14e-33 | 1.04e+00 | 0.108 |
| 728113 | ANXA8L1 | P24T-E | Human | Esophagus | ESCC | 2.61e-51 | 1.36e+00 | 0.1287 |
| 728113 | ANXA8L1 | P26T-E | Human | Esophagus | ESCC | 1.21e-34 | 6.06e-01 | 0.1276 |
| 728113 | ANXA8L1 | P27T-E | Human | Esophagus | ESCC | 1.24e-57 | 1.09e+00 | 0.1055 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005254726 | Esophagus | HGIN | regulation of peptidase activity | 102/2587 | 461/18723 | 6.29e-07 | 2.72e-05 | 102 |
| GO:005254826 | Esophagus | HGIN | regulation of endopeptidase activity | 96/2587 | 432/18723 | 1.09e-06 | 4.30e-05 | 96 |
| GO:001619710 | Esophagus | HGIN | endosomal transport | 57/2587 | 230/18723 | 5.74e-06 | 1.81e-04 | 57 |
| GO:00070328 | Esophagus | HGIN | endosome organization | 25/2587 | 82/18723 | 7.45e-05 | 1.69e-03 | 25 |
| GO:00160509 | Esophagus | HGIN | vesicle organization | 65/2587 | 300/18723 | 1.24e-04 | 2.54e-03 | 65 |
| GO:004586126 | Esophagus | HGIN | negative regulation of proteolysis | 68/2587 | 351/18723 | 2.21e-03 | 2.28e-02 | 68 |
| GO:005134620 | Esophagus | HGIN | negative regulation of hydrolase activity | 72/2587 | 379/18723 | 2.81e-03 | 2.75e-02 | 72 |
| GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
| GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
| GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
| GO:0052548111 | Esophagus | ESCC | regulation of endopeptidase activity | 253/8552 | 432/18723 | 3.68e-08 | 6.78e-07 | 253 |
| GO:000703214 | Esophagus | ESCC | endosome organization | 61/8552 | 82/18723 | 1.13e-07 | 1.85e-06 | 61 |
| GO:0045861111 | Esophagus | ESCC | negative regulation of proteolysis | 195/8552 | 351/18723 | 1.13e-04 | 7.85e-04 | 195 |
| GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
| GO:001046620 | Esophagus | ESCC | negative regulation of peptidase activity | 140/8552 | 262/18723 | 6.73e-03 | 2.46e-02 | 140 |
| GO:001095119 | Esophagus | ESCC | negative regulation of endopeptidase activity | 135/8552 | 252/18723 | 6.86e-03 | 2.51e-02 | 135 |
| GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
| GO:005254720 | Oral cavity | OSCC | regulation of peptidase activity | 255/7305 | 461/18723 | 5.78e-13 | 2.75e-11 | 255 |
| GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
| GO:005254820 | Oral cavity | OSCC | regulation of endopeptidase activity | 235/7305 | 432/18723 | 4.35e-11 | 1.40e-09 | 235 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.926N>T | p.Glu309Val | p.E309V | Q5VT79 | protein_coding | deleterious(0.01) | benign(0) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.634N>G | p.His212Asp | p.H212D | Q5VT79 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.354N>T | p.Glu118Asp | p.E118D | Q5VT79 | protein_coding | tolerated(0.05) | possibly_damaging(0.474) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.608C>A | p.Thr203Asn | p.T203N | Q5VT79 | protein_coding | tolerated(0.11) | probably_damaging(0.999) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.523G>C | p.Asp175His | p.D175H | Q5VT79 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-BG-A3PP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | PD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.415N>G | p.Tyr139Asp | p.Y139D | Q5VT79 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.398A>C | p.Lys133Thr | p.K133T | Q5VT79 | protein_coding | tolerated(0.21) | possibly_damaging(0.558) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.189C>G | p.Phe63Leu | p.F63L | Q5VT79 | protein_coding | deleterious(0.02) | possibly_damaging(0.877) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | novel | c.284N>G | p.Tyr95Cys | p.Y95C | Q5VT79 | protein_coding | tolerated(0.18) | probably_damaging(0.934) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ANXA8L1 | SNV | Missense_Mutation | c.547N>A | p.Ala183Thr | p.A183T | Q5VT79 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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