Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ANP32B

Gene summary for ANP32B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ANP32B

Gene ID

10541

Gene nameacidic nuclear phosphoprotein 32 family member B
Gene AliasAPRIL
Cytomap9q22.33
Gene Typeprotein-coding
GO ID

GO:0001944

UniProtAcc

Q92688


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10541ANP32BGSM4909281HumanBreastIDC9.69e-286.26e-010.21
10541ANP32BGSM4909282HumanBreastIDC6.53e-195.03e-01-0.0288
10541ANP32BGSM4909285HumanBreastIDC3.38e-457.78e-010.21
10541ANP32BGSM4909286HumanBreastIDC1.80e-093.38e-010.1081
10541ANP32BGSM4909288HumanBreastIDC8.94e-092.96e-010.0988
10541ANP32BGSM4909294HumanBreastIDC4.28e-05-1.80e-010.2022
10541ANP32BGSM4909296HumanBreastIDC4.70e-11-9.31e-020.1524
10541ANP32BGSM4909297HumanBreastIDC1.36e-17-1.79e-010.1517
10541ANP32BGSM4909301HumanBreastIDC1.43e-02-1.43e-010.1577
10541ANP32BGSM4909311HumanBreastIDC2.04e-30-3.63e-010.1534
10541ANP32BGSM4909312HumanBreastIDC1.17e-11-6.52e-020.1552
10541ANP32BGSM4909319HumanBreastIDC1.54e-44-4.20e-010.1563
10541ANP32BGSM4909320HumanBreastIDC1.64e-05-4.35e-010.1575
10541ANP32BGSM4909321HumanBreastIDC2.72e-15-2.80e-010.1559
10541ANP32BM1HumanBreastIDC2.59e-033.39e-010.1577
10541ANP32BM2HumanBreastIDC1.67e-136.17e-010.21
10541ANP32BNCCBC14HumanBreastDCIS1.74e-101.38e-010.2021
10541ANP32BNCCBC2HumanBreastDCIS1.66e-04-1.73e-010.1554
10541ANP32BNCCBC3HumanBreastDCIS1.13e-092.44e-010.1198
10541ANP32BNCCBC5HumanBreastDCIS2.05e-181.20e-010.2046
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005254714BreastIDCregulation of peptidase activity96/1434461/187237.58e-206.15e-1796
GO:005254814BreastIDCregulation of endopeptidase activity88/1434432/187231.20e-174.85e-1588
GO:200011614BreastIDCregulation of cysteine-type endopeptidase activity55/1434235/187234.25e-141.21e-1155
GO:004328114BreastIDCregulation of cysteine-type endopeptidase activity involved in apoptotic process50/1434209/187232.49e-136.14e-1150
GO:004586214BreastIDCpositive regulation of proteolysis66/1434372/187239.76e-111.29e-0866
GO:001095214BreastIDCpositive regulation of peptidase activity40/1434197/187231.04e-087.67e-0740
GO:004328013BreastIDCpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process29/1434129/187231.10e-076.35e-0629
GO:200105613BreastIDCpositive regulation of cysteine-type endopeptidase activity31/1434148/187232.22e-071.17e-0531
GO:001095013BreastIDCpositive regulation of endopeptidase activity35/1434179/187232.24e-071.17e-0535
GO:000691911BreastIDCactivation of cysteine-type endopeptidase activity involved in apoptotic process19/143478/187234.75e-061.63e-0419
GO:190495113BreastIDCpositive regulation of establishment of protein localization45/1434319/187235.01e-051.09e-0345
GO:005122213BreastIDCpositive regulation of protein transport40/1434303/187235.14e-046.70e-0340
GO:00331578BreastIDCregulation of intracellular protein transport29/1434229/187235.16e-033.84e-0229
GO:00323888BreastIDCpositive regulation of intracellular transport26/1434202/187236.33e-034.47e-0226
GO:00468258BreastIDCregulation of protein export from nucleus7/143430/187236.48e-034.56e-027
GO:005254723BreastDCISregulation of peptidase activity88/1390461/187231.18e-164.78e-1488
GO:005254823BreastDCISregulation of endopeptidase activity83/1390432/187236.07e-162.15e-1383
GO:200011623BreastDCISregulation of cysteine-type endopeptidase activity54/1390235/187234.56e-141.29e-1154
GO:004328123BreastDCISregulation of cysteine-type endopeptidase activity involved in apoptotic process49/1390209/187233.05e-137.19e-1149
GO:004586224BreastDCISpositive regulation of proteolysis65/1390372/187237.13e-119.17e-0965
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ANP32BSNVMissense_Mutationnovelc.185A>Tp.Lys62Metp.K62MQ92688protein_codingdeleterious(0)probably_damaging(0.931)TCGA-A2-A4S3-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ANP32BSNVMissense_Mutationnovelc.178N>Ap.Leu60Ilep.L60IQ92688protein_codingdeleterious(0.03)possibly_damaging(0.818)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ANP32BSNVMissense_Mutationc.616G>Ap.Asp206Asnp.D206NQ92688protein_codingtolerated(0.16)benign(0.011)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ANP32BSNVMissense_Mutationc.697N>Cp.Glu233Glnp.E233QQ92688protein_codingtolerated(0.1)benign(0.259)TCGA-IR-A3LH-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANP32BSNVMissense_Mutationc.241G>Cp.Asp81Hisp.D81HQ92688protein_codingdeleterious(0.02)possibly_damaging(0.869)TCGA-MY-A5BD-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANP32BSNVMissense_Mutationc.623N>Gp.Glu208Glyp.E208GQ92688protein_codingtolerated(0.17)probably_damaging(0.932)TCGA-AD-6895-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
ANP32BSNVMissense_Mutationc.179N>Gp.Leu60Argp.L60RQ92688protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AZ-5403-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownPD
ANP32BSNVMissense_Mutationrs761031783c.619N>Ap.Asp207Asnp.D207NQ92688protein_codingtolerated(0.23)benign(0.142)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ANP32BSNVMissense_Mutationc.753N>Gp.Asp251Glup.D251EQ92688protein_codingdeleterious_low_confidence(0)benign(0.225)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ANP32BSNVMissense_Mutationnovelc.598N>Ap.Val200Ilep.V200IQ92688protein_codingtolerated(0.42)benign(0.001)TCGA-AX-A06F-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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