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Gene: ANO10 |
Gene summary for ANO10 |
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Gene information | Species | Human | Gene symbol | ANO10 | Gene ID | 55129 |
Gene name | anoctamin 10 | |
Gene Alias | SCAR10 | |
Cytomap | 3p22.1-p21.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NW15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55129 | ANO10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.08e-18 | -4.92e-01 | 0.0155 |
55129 | ANO10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.63e-06 | 4.64e-01 | -0.1954 |
55129 | ANO10 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.99e-13 | -6.50e-01 | 0.096 |
55129 | ANO10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.57e-03 | -6.17e-01 | 0.0528 |
55129 | ANO10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.97e-11 | -4.57e-01 | 0.0674 |
55129 | ANO10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.10e-20 | -6.56e-01 | 0.294 |
55129 | ANO10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.36e-07 | -4.08e-01 | 0.3859 |
55129 | ANO10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.63e-07 | -7.11e-01 | 0.2585 |
55129 | ANO10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.40e-30 | -7.38e-01 | 0.3005 |
55129 | ANO10 | F007 | Human | Colorectum | FAP | 2.66e-02 | -3.52e-01 | 0.1176 |
55129 | ANO10 | A001-C-207 | Human | Colorectum | FAP | 2.11e-07 | -4.95e-01 | 0.1278 |
55129 | ANO10 | A015-C-203 | Human | Colorectum | FAP | 2.55e-38 | -6.13e-01 | -0.1294 |
55129 | ANO10 | A015-C-204 | Human | Colorectum | FAP | 2.10e-05 | -3.53e-01 | -0.0228 |
55129 | ANO10 | A014-C-040 | Human | Colorectum | FAP | 2.78e-07 | -6.56e-01 | -0.1184 |
55129 | ANO10 | A002-C-201 | Human | Colorectum | FAP | 1.75e-21 | -6.04e-01 | 0.0324 |
55129 | ANO10 | A002-C-203 | Human | Colorectum | FAP | 2.18e-02 | -2.80e-01 | 0.2786 |
55129 | ANO10 | A001-C-119 | Human | Colorectum | FAP | 2.77e-17 | -8.02e-01 | -0.1557 |
55129 | ANO10 | A001-C-108 | Human | Colorectum | FAP | 2.52e-27 | -5.91e-01 | -0.0272 |
55129 | ANO10 | A002-C-205 | Human | Colorectum | FAP | 5.76e-31 | -7.47e-01 | -0.1236 |
55129 | ANO10 | A001-C-104 | Human | Colorectum | FAP | 3.25e-09 | -4.49e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO10 | SNV | Missense_Mutation | novel | c.409G>T | p.Ala137Ser | p.A137S | Q9NW15 | protein_coding | tolerated(0.06) | possibly_damaging(0.593) | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
ANO10 | SNV | Missense_Mutation | c.397N>C | p.Glu133Gln | p.E133Q | Q9NW15 | protein_coding | deleterious(0.01) | benign(0.206) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANO10 | SNV | Missense_Mutation | c.333N>G | p.Phe111Leu | p.F111L | Q9NW15 | protein_coding | tolerated(0.05) | benign(0.027) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANO10 | SNV | Missense_Mutation | c.1931N>T | p.Thr644Ile | p.T644I | Q9NW15 | protein_coding | tolerated(0.06) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANO10 | SNV | Missense_Mutation | c.1564G>T | p.Ala522Ser | p.A522S | Q9NW15 | protein_coding | deleterious(0.04) | probably_damaging(0.965) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ANO10 | SNV | Missense_Mutation | novel | c.517N>A | p.Leu173Met | p.L173M | Q9NW15 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-S3-AA0Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Ancillary | neulasta | CR |
ANO10 | insertion | Frame_Shift_Ins | novel | c.157_158insTCTCCTG | p.Arg53IlefsTer8 | p.R53Ifs*8 | Q9NW15 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ANO10 | insertion | Frame_Shift_Ins | novel | c.1936_1937insTCCTTGGCAGTTCCCCCAGCCCCACCCTGTCTGCTCCTTCCCAGTTC | p.Asn646IlefsTer18 | p.N646Ifs*18 | Q9NW15 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
ANO10 | SNV | Missense_Mutation | rs140132703 | c.1289G>A | p.Arg430His | p.R430H | Q9NW15 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANO10 | SNV | Missense_Mutation | c.373N>G | p.Gln125Glu | p.Q125E | Q9NW15 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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