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Gene: ANKRD49 |
Gene summary for ANKRD49 |
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Gene information | Species | Human | Gene symbol | ANKRD49 | Gene ID | 54851 |
Gene name | ankyrin repeat domain 49 | |
Gene Alias | FGIF | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R398 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54851 | ANKRD49 | LZE4T | Human | Esophagus | ESCC | 1.18e-05 | 9.97e-02 | 0.0811 |
54851 | ANKRD49 | LZE5T | Human | Esophagus | ESCC | 2.27e-02 | 2.90e-01 | 0.0514 |
54851 | ANKRD49 | LZE7T | Human | Esophagus | ESCC | 1.26e-04 | 1.22e-01 | 0.0667 |
54851 | ANKRD49 | LZE20T | Human | Esophagus | ESCC | 3.06e-07 | 1.99e-01 | 0.0662 |
54851 | ANKRD49 | LZE22D1 | Human | Esophagus | HGIN | 2.58e-02 | 1.28e-01 | 0.0595 |
54851 | ANKRD49 | LZE24T | Human | Esophagus | ESCC | 2.54e-18 | 3.77e-01 | 0.0596 |
54851 | ANKRD49 | P1T-E | Human | Esophagus | ESCC | 7.93e-05 | 1.68e-01 | 0.0875 |
54851 | ANKRD49 | P2T-E | Human | Esophagus | ESCC | 2.33e-12 | 1.20e-01 | 0.1177 |
54851 | ANKRD49 | P4T-E | Human | Esophagus | ESCC | 1.00e-16 | 3.92e-01 | 0.1323 |
54851 | ANKRD49 | P5T-E | Human | Esophagus | ESCC | 3.20e-07 | 8.96e-02 | 0.1327 |
54851 | ANKRD49 | P8T-E | Human | Esophagus | ESCC | 7.61e-33 | 6.25e-01 | 0.0889 |
54851 | ANKRD49 | P9T-E | Human | Esophagus | ESCC | 1.22e-10 | 2.36e-01 | 0.1131 |
54851 | ANKRD49 | P10T-E | Human | Esophagus | ESCC | 4.17e-20 | 3.07e-01 | 0.116 |
54851 | ANKRD49 | P11T-E | Human | Esophagus | ESCC | 2.27e-06 | 1.20e-01 | 0.1426 |
54851 | ANKRD49 | P12T-E | Human | Esophagus | ESCC | 1.13e-13 | 2.76e-01 | 0.1122 |
54851 | ANKRD49 | P15T-E | Human | Esophagus | ESCC | 1.58e-06 | 2.03e-02 | 0.1149 |
54851 | ANKRD49 | P16T-E | Human | Esophagus | ESCC | 2.36e-03 | 6.08e-02 | 0.1153 |
54851 | ANKRD49 | P17T-E | Human | Esophagus | ESCC | 1.82e-04 | 1.96e-01 | 0.1278 |
54851 | ANKRD49 | P20T-E | Human | Esophagus | ESCC | 7.95e-06 | 1.23e-01 | 0.1124 |
54851 | ANKRD49 | P21T-E | Human | Esophagus | ESCC | 9.15e-15 | 1.74e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD49 | SNV | Missense_Mutation | novel | c.227N>A | p.Arg76Lys | p.R76K | Q8WVL7 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD49 | SNV | Missense_Mutation | c.64N>A | p.Glu22Lys | p.E22K | Q8WVL7 | protein_coding | deleterious(0.01) | benign(0.314) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
ANKRD49 | SNV | Missense_Mutation | novel | c.564N>T | p.Lys188Asn | p.K188N | Q8WVL7 | protein_coding | tolerated(0.16) | benign(0.012) | TCGA-S3-AA15-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ANKRD49 | insertion | In_Frame_Ins | novel | c.204_205insTCC | p.Lys68_Lys69insSer | p.K68_K69insS | Q8WVL7 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
ANKRD49 | insertion | In_Frame_Ins | novel | c.204_205insTCC | p.Lys68_Lys69insSer | p.K68_K69insS | Q8WVL7 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKRD49 | SNV | Missense_Mutation | c.271N>T | p.Arg91Trp | p.R91W | Q8WVL7 | protein_coding | deleterious(0.01) | possibly_damaging(0.773) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ANKRD49 | SNV | Missense_Mutation | c.428N>T | p.Thr143Met | p.T143M | Q8WVL7 | protein_coding | tolerated(0.05) | possibly_damaging(0.85) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
ANKRD49 | SNV | Missense_Mutation | c.316G>A | p.Glu106Lys | p.E106K | Q8WVL7 | protein_coding | tolerated(0.32) | benign(0.16) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ANKRD49 | SNV | Missense_Mutation | rs369504802 | c.670N>C | p.Tyr224His | p.Y224H | Q8WVL7 | protein_coding | tolerated(0.37) | possibly_damaging(0.783) | TCGA-QG-A5YX-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
ANKRD49 | SNV | Missense_Mutation | c.647N>G | p.Ala216Gly | p.A216G | Q8WVL7 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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