![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ANKRD36B |
Gene summary for ANKRD36B |
![]() |
Gene information | Species | Human | Gene symbol | ANKRD36B | Gene ID | 57730 |
Gene name | ankyrin repeat domain 36B | |
Gene Alias | KIAA1641 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N2N9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57730 | ANKRD36B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.01e-02 | -2.75e-01 | 0.0155 |
57730 | ANKRD36B | A015-C-203 | Human | Colorectum | FAP | 1.80e-07 | 2.28e-01 | -0.1294 |
57730 | ANKRD36B | A015-C-204 | Human | Colorectum | FAP | 3.55e-02 | 3.42e-01 | -0.0228 |
57730 | ANKRD36B | A002-C-201 | Human | Colorectum | FAP | 1.95e-04 | 3.25e-01 | 0.0324 |
57730 | ANKRD36B | A002-C-203 | Human | Colorectum | FAP | 1.36e-06 | 4.50e-01 | 0.2786 |
57730 | ANKRD36B | A001-C-108 | Human | Colorectum | FAP | 3.19e-04 | 3.68e-01 | -0.0272 |
57730 | ANKRD36B | A002-C-021 | Human | Colorectum | FAP | 3.50e-17 | 5.65e-01 | 0.1171 |
57730 | ANKRD36B | A002-C-205 | Human | Colorectum | FAP | 1.01e-07 | 2.97e-01 | -0.1236 |
57730 | ANKRD36B | A001-C-104 | Human | Colorectum | FAP | 2.72e-05 | 4.61e-01 | 0.0184 |
57730 | ANKRD36B | A015-C-006 | Human | Colorectum | FAP | 5.99e-07 | 3.65e-01 | -0.0994 |
57730 | ANKRD36B | A002-C-114 | Human | Colorectum | FAP | 3.20e-06 | 3.30e-01 | -0.1561 |
57730 | ANKRD36B | A015-C-104 | Human | Colorectum | FAP | 8.49e-08 | 1.13e-01 | -0.1899 |
57730 | ANKRD36B | A001-C-014 | Human | Colorectum | FAP | 3.14e-14 | 6.62e-01 | 0.0135 |
57730 | ANKRD36B | A002-C-016 | Human | Colorectum | FAP | 4.71e-11 | 4.40e-01 | 0.0521 |
57730 | ANKRD36B | A001-C-203 | Human | Colorectum | FAP | 4.43e-07 | 4.50e-01 | -0.0481 |
57730 | ANKRD36B | A002-C-116 | Human | Colorectum | FAP | 1.91e-05 | 2.45e-03 | -0.0452 |
57730 | ANKRD36B | F034 | Human | Colorectum | FAP | 3.71e-05 | 3.00e-01 | -0.0665 |
57730 | ANKRD36B | CRC-1-8810 | Human | Colorectum | CRC | 3.17e-10 | 4.97e-01 | 0.6257 |
57730 | ANKRD36B | LZE4T | Human | Esophagus | ESCC | 1.61e-10 | 2.35e-01 | 0.0811 |
57730 | ANKRD36B | LZE7T | Human | Esophagus | ESCC | 4.96e-11 | 4.80e-01 | 0.0667 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD36B | SNV | Missense_Mutation | novel | c.1319A>G | p.Lys440Arg | p.K440R | Q8N2N9 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-A2-A0EP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ANKRD36B | SNV | Missense_Mutation | novel | c.843N>C | p.Lys281Asn | p.K281N | Q8N2N9 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ANKRD36B | SNV | Missense_Mutation | novel | c.550N>T | p.Leu184Phe | p.L184F | Q8N2N9 | protein_coding | tolerated(0.15) | benign(0.205) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ANKRD36B | SNV | Missense_Mutation | novel | c.788N>G | p.Glu263Gly | p.E263G | Q8N2N9 | protein_coding | tolerated(0.51) | benign(0) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
ANKRD36B | insertion | In_Frame_Ins | novel | c.786_787insTTG | p.Ala262_Glu263insLeu | p.A262_E263insL | Q8N2N9 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
ANKRD36B | insertion | Frame_Shift_Ins | novel | c.1997_1998insTA | p.Gln666HisfsTer18 | p.Q666Hfs*18 | Q8N2N9 | protein_coding | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ANKRD36B | insertion | In_Frame_Ins | novel | c.1995_1996insTTC | p.Pro665_Gln666insPhe | p.P665_Q666insF | Q8N2N9 | protein_coding | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ANKRD36B | SNV | Missense_Mutation | novel | c.1906G>A | p.Ala636Thr | p.A636T | Q8N2N9 | protein_coding | tolerated(0.23) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANKRD36B | SNV | Missense_Mutation | novel | c.2216N>T | p.Ser739Leu | p.S739L | Q8N2N9 | protein_coding | deleterious(0) | benign(0.031) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD36B | SNV | Missense_Mutation | novel | c.97N>G | p.Leu33Val | p.L33V | Q8N2N9 | protein_coding | tolerated(1) | benign(0.007) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |