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Gene: ANKH |
Gene summary for ANKH |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ANKH | Gene ID | 56172 |
| Gene name | ANKH inorganic pyrophosphate transport regulator | |
| Gene Alias | ANK | |
| Cytomap | 5p15.2 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9HCJ1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 56172 | ANKH | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.58e-08 | 8.25e-01 | -0.0811 |
| 56172 | ANKH | HTA11_78_2000001011 | Human | Colorectum | AD | 2.10e-04 | 6.33e-01 | -0.1088 |
| 56172 | ANKH | HTA11_347_2000001011 | Human | Colorectum | AD | 1.62e-02 | 3.75e-01 | -0.1954 |
| 56172 | ANKH | HTA11_866_2000001011 | Human | Colorectum | AD | 1.34e-05 | 5.56e-01 | -0.1001 |
| 56172 | ANKH | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.05e-07 | 1.12e+00 | -0.059 |
| 56172 | ANKH | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.59e-02 | 7.07e-01 | 0.0131 |
| 56172 | ANKH | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-02 | 6.33e-01 | 0.0338 |
| 56172 | ANKH | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.22e-03 | 7.16e-01 | 0.0112 |
| 56172 | ANKH | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.96e-10 | 9.35e-01 | 0.0588 |
| 56172 | ANKH | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.27e-04 | 9.19e-01 | 0.3487 |
| 56172 | ANKH | A001-C-207 | Human | Colorectum | FAP | 7.46e-04 | 1.29e-01 | 0.1278 |
| 56172 | ANKH | A015-C-203 | Human | Colorectum | FAP | 2.60e-28 | -1.75e-01 | -0.1294 |
| 56172 | ANKH | A015-C-204 | Human | Colorectum | FAP | 4.71e-06 | 1.31e-01 | -0.0228 |
| 56172 | ANKH | A014-C-040 | Human | Colorectum | FAP | 8.36e-05 | 3.99e-02 | -0.1184 |
| 56172 | ANKH | A002-C-201 | Human | Colorectum | FAP | 3.66e-16 | 1.75e-01 | 0.0324 |
| 56172 | ANKH | A002-C-203 | Human | Colorectum | FAP | 8.78e-08 | 3.25e-01 | 0.2786 |
| 56172 | ANKH | A001-C-119 | Human | Colorectum | FAP | 8.14e-05 | -2.11e-01 | -0.1557 |
| 56172 | ANKH | A001-C-108 | Human | Colorectum | FAP | 4.42e-15 | -1.17e-01 | -0.0272 |
| 56172 | ANKH | A002-C-205 | Human | Colorectum | FAP | 1.31e-22 | -1.63e-01 | -0.1236 |
| 56172 | ANKH | A015-C-005 | Human | Colorectum | FAP | 6.15e-09 | -3.68e-01 | -0.0336 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
| GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
| GO:00015031 | Colorectum | SER | ossification | 82/2897 | 408/18723 | 6.76e-03 | 4.78e-02 | 82 |
| GO:00015033 | Colorectum | FAP | ossification | 79/2622 | 408/18723 | 1.53e-03 | 1.37e-02 | 79 |
| GO:0030278 | Colorectum | FAP | regulation of ossification | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
| GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
| GO:00015034 | Colorectum | CRC | ossification | 64/2078 | 408/18723 | 2.73e-03 | 2.49e-02 | 64 |
| GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
| GO:00015035 | Liver | Cirrhotic | ossification | 127/4634 | 408/18723 | 1.89e-03 | 1.19e-02 | 127 |
| GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
| GO:000150315 | Oral cavity | LP | ossification | 123/4623 | 408/18723 | 6.55e-03 | 3.84e-02 | 123 |
| GO:00015039 | Prostate | BPH | ossification | 107/3107 | 408/18723 | 4.31e-07 | 8.83e-06 | 107 |
| GO:00302782 | Prostate | BPH | regulation of ossification | 29/3107 | 115/18723 | 1.18e-02 | 4.76e-02 | 29 |
| GO:000150314 | Prostate | Tumor | ossification | 109/3246 | 408/18723 | 1.13e-06 | 2.14e-05 | 109 |
| GO:003027811 | Prostate | Tumor | regulation of ossification | 32/3246 | 115/18723 | 3.39e-03 | 1.75e-02 | 32 |
| GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
| GO:00302785 | Thyroid | PTC | regulation of ossification | 51/5968 | 115/18723 | 3.30e-03 | 1.61e-02 | 51 |
| GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
| GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
| GO:01101492 | Thyroid | ATC | regulation of biomineralization | 45/6293 | 99/18723 | 9.34e-03 | 3.44e-02 | 45 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ANKH | SNV | Missense_Mutation | c.563N>T | p.Glu188Val | p.E188V | Q9HCJ1 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ANKH | SNV | Missense_Mutation | rs142872069 | c.668N>T | p.Arg223Ile | p.R223I | Q9HCJ1 | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ANKH | SNV | Missense_Mutation | c.1118N>A | p.Ile373Asn | p.I373N | Q9HCJ1 | protein_coding | deleterious(0) | possibly_damaging(0.467) | TCGA-B6-A0WS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ANKH | SNV | Missense_Mutation | c.383N>T | p.Thr128Met | p.T128M | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| ANKH | insertion | Frame_Shift_Ins | novel | c.1408_1409insGT | p.Ser470CysfsTer4 | p.S470Cfs*4 | Q9HCJ1 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| ANKH | insertion | In_Frame_Ins | novel | c.1406_1407insAAGAAAAAGGCAGGCCCTTTGTGTCTACCGTTTTCAGTG | p.Asp469delinsGluArgLysArgGlnAlaLeuCysValTyrArgPheGlnCys | p.D469delinsERKRQALCVYRFQC | Q9HCJ1 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| ANKH | insertion | In_Frame_Ins | novel | c.1142_1143insGCCACTTCAATA | p.Val381_Thr382insProLeuGlnTyr | p.V381_T382insPLQY | Q9HCJ1 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ANKH | SNV | Missense_Mutation | novel | c.1318G>C | p.Glu440Gln | p.E440Q | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ANKH | SNV | Missense_Mutation | c.851N>A | p.Pro284His | p.P284H | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ANKH | SNV | Missense_Mutation | c.1154C>T | p.Ala385Val | p.A385V | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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