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Gene: AMZ2 |
Gene summary for AMZ2 |
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Gene information | Species | Human | Gene symbol | AMZ2 | Gene ID | 51321 |
Gene name | archaelysin family metallopeptidase 2 | |
Gene Alias | AMZ2 | |
Cytomap | 17q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q86W34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51321 | AMZ2 | LZE4T | Human | Esophagus | ESCC | 3.18e-20 | 6.34e-01 | 0.0811 |
51321 | AMZ2 | LZE5T | Human | Esophagus | ESCC | 1.95e-02 | 2.40e-01 | 0.0514 |
51321 | AMZ2 | LZE7T | Human | Esophagus | ESCC | 4.48e-09 | 7.02e-01 | 0.0667 |
51321 | AMZ2 | LZE8T | Human | Esophagus | ESCC | 7.29e-12 | 3.56e-01 | 0.067 |
51321 | AMZ2 | LZE20T | Human | Esophagus | ESCC | 4.67e-04 | 1.75e-01 | 0.0662 |
51321 | AMZ2 | LZE22D1 | Human | Esophagus | HGIN | 4.77e-07 | 2.81e-01 | 0.0595 |
51321 | AMZ2 | LZE22T | Human | Esophagus | ESCC | 4.89e-07 | 7.21e-01 | 0.068 |
51321 | AMZ2 | LZE24T | Human | Esophagus | ESCC | 2.76e-35 | 1.11e+00 | 0.0596 |
51321 | AMZ2 | LZE6T | Human | Esophagus | ESCC | 2.67e-09 | 5.66e-01 | 0.0845 |
51321 | AMZ2 | P1T-E | Human | Esophagus | ESCC | 8.38e-08 | 3.51e-01 | 0.0875 |
51321 | AMZ2 | P2T-E | Human | Esophagus | ESCC | 1.14e-55 | 9.42e-01 | 0.1177 |
51321 | AMZ2 | P4T-E | Human | Esophagus | ESCC | 1.35e-35 | 7.49e-01 | 0.1323 |
51321 | AMZ2 | P5T-E | Human | Esophagus | ESCC | 1.73e-64 | 1.45e+00 | 0.1327 |
51321 | AMZ2 | P8T-E | Human | Esophagus | ESCC | 2.37e-35 | 6.45e-01 | 0.0889 |
51321 | AMZ2 | P9T-E | Human | Esophagus | ESCC | 5.30e-18 | 4.41e-01 | 0.1131 |
51321 | AMZ2 | P10T-E | Human | Esophagus | ESCC | 6.19e-47 | 9.34e-01 | 0.116 |
51321 | AMZ2 | P11T-E | Human | Esophagus | ESCC | 2.47e-17 | 8.24e-01 | 0.1426 |
51321 | AMZ2 | P12T-E | Human | Esophagus | ESCC | 2.37e-55 | 1.00e+00 | 0.1122 |
51321 | AMZ2 | P15T-E | Human | Esophagus | ESCC | 2.68e-41 | 8.28e-01 | 0.1149 |
51321 | AMZ2 | P16T-E | Human | Esophagus | ESCC | 1.49e-35 | 8.10e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMZ2 | SNV | Missense_Mutation | c.220N>G | p.Phe74Val | p.F74V | Q86W34 | protein_coding | deleterious(0.01) | benign(0.073) | TCGA-A1-A0SJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | c.525N>A | p.Met175Ile | p.M175I | Q86W34 | protein_coding | deleterious(0.01) | benign(0.214) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AMZ2 | SNV | Missense_Mutation | rs782216581 | c.805N>T | p.Ala269Ser | p.A269S | Q86W34 | protein_coding | tolerated(0.92) | benign(0.011) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMZ2 | SNV | Missense_Mutation | rs782809066 | c.77N>G | p.Tyr26Cys | p.Y26C | Q86W34 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
AMZ2 | SNV | Missense_Mutation | novel | c.368G>T | p.Arg123Ile | p.R123I | Q86W34 | protein_coding | tolerated(0.06) | benign(0.015) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMZ2 | insertion | Frame_Shift_Ins | novel | c.207_208insCTCTATATAGGAACACGATGTGAATGGAAGAAACCTGTCA | p.Phe70LeufsTer15 | p.F70Lfs*15 | Q86W34 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
AMZ2 | SNV | Missense_Mutation | c.542G>C | p.Arg181Thr | p.R181T | Q86W34 | protein_coding | tolerated(0.07) | possibly_damaging(0.617) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | c.622N>C | p.Asp208His | p.D208H | Q86W34 | protein_coding | tolerated(0.11) | benign(0.067) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
AMZ2 | SNV | Missense_Mutation | c.684N>A | p.Asp228Glu | p.D228E | Q86W34 | protein_coding | tolerated(0.41) | benign(0.046) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | novel | c.450N>G | p.Ile150Met | p.I150M | Q86W34 | protein_coding | deleterious(0.01) | possibly_damaging(0.535) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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