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Gene: AMACR |
Gene summary for AMACR |
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Gene information | Species | Human | Gene symbol | AMACR | Gene ID | 23600 |
Gene name | alpha-methylacyl-CoA racemase | |
Gene Alias | AMACRD | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9UHK6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23600 | AMACR | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.24e-11 | 3.28e-01 | 0.0155 |
23600 | AMACR | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.91e-07 | 2.57e-01 | -0.1808 |
23600 | AMACR | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.23e-10 | 4.80e-01 | -0.0811 |
23600 | AMACR | HTA11_78_2000001011 | Human | Colorectum | AD | 8.54e-10 | 3.09e-01 | -0.1088 |
23600 | AMACR | HTA11_347_2000001011 | Human | Colorectum | AD | 7.77e-25 | 5.48e-01 | -0.1954 |
23600 | AMACR | HTA11_411_2000001011 | Human | Colorectum | SER | 1.41e-05 | 4.63e-01 | -0.2602 |
23600 | AMACR | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.49e-03 | 2.69e-01 | -0.1207 |
23600 | AMACR | HTA11_83_2000001011 | Human | Colorectum | SER | 4.20e-03 | 2.48e-01 | -0.1526 |
23600 | AMACR | HTA11_696_2000001011 | Human | Colorectum | AD | 1.84e-13 | 3.69e-01 | -0.1464 |
23600 | AMACR | HTA11_866_2000001011 | Human | Colorectum | AD | 1.09e-06 | 2.80e-01 | -0.1001 |
23600 | AMACR | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.13e-11 | 4.79e-01 | -0.059 |
23600 | AMACR | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.85e-05 | 3.69e-01 | -0.1706 |
23600 | AMACR | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.46e-13 | 5.76e-01 | -0.2061 |
23600 | AMACR | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.02e-02 | 2.07e-01 | -0.0179 |
23600 | AMACR | HTA11_866_3004761011 | Human | Colorectum | AD | 4.06e-15 | 4.30e-01 | 0.096 |
23600 | AMACR | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.56e-02 | 1.93e-01 | 0.0338 |
23600 | AMACR | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.56e-11 | 3.51e-01 | 0.0674 |
23600 | AMACR | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.47e-04 | 2.21e-01 | 0.0588 |
23600 | AMACR | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.51e-34 | 8.54e-01 | 0.294 |
23600 | AMACR | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.16e-02 | 4.24e-01 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00090621 | Colorectum | SER | fatty acid catabolic process | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00066351 | Colorectum | SER | fatty acid beta-oxidation | 24/2897 | 74/18723 | 2.09e-04 | 3.77e-03 | 24 |
GO:00723291 | Colorectum | SER | monocarboxylic acid catabolic process | 34/2897 | 122/18723 | 3.27e-04 | 5.22e-03 | 34 |
GO:00193951 | Colorectum | SER | fatty acid oxidation | 29/2897 | 103/18723 | 7.24e-04 | 9.44e-03 | 29 |
GO:00442421 | Colorectum | SER | cellular lipid catabolic process | 51/2897 | 214/18723 | 8.60e-04 | 1.05e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa001202 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa001203 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMACR | SNV | Missense_Mutation | rs774406448 | c.1084G>A | p.Glu362Lys | p.E362K | Q9UHK6 | protein_coding | tolerated(0.48) | benign(0.005) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
AMACR | SNV | Missense_Mutation | rs750174939 | c.977G>A | p.Arg326His | p.R326H | Q9UHK6 | protein_coding | tolerated(0.07) | benign(0.081) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
AMACR | SNV | Missense_Mutation | c.790T>C | p.Trp264Arg | p.W264R | Q9UHK6 | protein_coding | deleterious(0.01) | probably_damaging(0.911) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AMACR | SNV | Missense_Mutation | rs774180397 | c.887C>T | p.Pro296Leu | p.P296L | Q9UHK6 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AMACR | SNV | Missense_Mutation | c.541N>A | p.Asp181Asn | p.D181N | Q9UHK6 | protein_coding | deleterious(0.02) | possibly_damaging(0.84) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AMACR | SNV | Missense_Mutation | c.413N>A | p.Arg138Lys | p.R138K | Q9UHK6 | protein_coding | deleterious(0.05) | benign(0.02) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AMACR | SNV | Missense_Mutation | rs113840552 | c.434C>T | p.Ala145Val | p.A145V | Q9UHK6 | protein_coding | tolerated(0.17) | possibly_damaging(0.559) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AMACR | SNV | Missense_Mutation | rs201818706 | c.518N>A | p.Arg173His | p.R173H | Q9UHK6 | protein_coding | tolerated(0.11) | benign(0.03) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMACR | SNV | Missense_Mutation | c.490A>G | p.Ile164Val | p.I164V | Q9UHK6 | protein_coding | tolerated(0.08) | possibly_damaging(0.574) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AMACR | SNV | Missense_Mutation | novel | c.739N>A | p.Gly247Arg | p.G247R | Q9UHK6 | protein_coding | tolerated(0.27) | benign(0.059) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23600 | AMACR | ENZYME | cholic acid | |||
23600 | AMACR | ENZYME | ibuprofen | IBUPROFEN | 25502615 |
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