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Gene: ALOX5 |
Gene summary for ALOX5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ALOX5 | Gene ID | 240 |
| Gene name | arachidonate 5-lipoxygenase | |
| Gene Alias | 5-LO | |
| Cytomap | 10q11.21 | |
| Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P09917 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 240 | ALOX5 | CCII_1 | Human | Cervix | CC | 1.05e-05 | -4.81e-01 | 0.3249 |
| 240 | ALOX5 | Tumor | Human | Cervix | CC | 4.26e-15 | -4.77e-01 | 0.1241 |
| 240 | ALOX5 | sample1 | Human | Cervix | CC | 3.83e-05 | -4.94e-01 | 0.0959 |
| 240 | ALOX5 | sample3 | Human | Cervix | CC | 1.95e-16 | -4.78e-01 | 0.1387 |
| 240 | ALOX5 | H2 | Human | Cervix | HSIL_HPV | 1.77e-14 | -4.69e-01 | 0.0632 |
| 240 | ALOX5 | L1 | Human | Cervix | CC | 6.76e-07 | -4.51e-01 | 0.0802 |
| 240 | ALOX5 | T1 | Human | Cervix | CC | 1.19e-11 | -4.77e-01 | 0.0918 |
| 240 | ALOX5 | T3 | Human | Cervix | CC | 8.13e-12 | -4.59e-01 | 0.1389 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
| GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
| GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
| GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
| GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
| GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
| GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
| GO:00603267 | Cervix | CC | cell chemotaxis | 73/2311 | 310/18723 | 2.82e-08 | 1.96e-06 | 73 |
| GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
| GO:006219710 | Cervix | CC | cellular response to chemical stress | 76/2311 | 337/18723 | 1.01e-07 | 5.25e-06 | 76 |
| GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
| GO:00305957 | Cervix | CC | leukocyte chemotaxis | 57/2311 | 230/18723 | 1.48e-07 | 7.07e-06 | 57 |
| GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
| GO:190589710 | Cervix | CC | regulation of response to endoplasmic reticulum stress | 27/2311 | 82/18723 | 9.24e-07 | 3.25e-05 | 27 |
| GO:00509007 | Cervix | CC | leukocyte migration | 78/2311 | 369/18723 | 1.09e-06 | 3.80e-05 | 78 |
| GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
| GO:003459910 | Cervix | CC | cellular response to oxidative stress | 63/2311 | 288/18723 | 3.58e-06 | 9.50e-05 | 63 |
| GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
| GO:003497610 | Cervix | CC | response to endoplasmic reticulum stress | 57/2311 | 256/18723 | 5.81e-06 | 1.42e-04 | 57 |
| GO:190357310 | Cervix | CC | negative regulation of response to endoplasmic reticulum stress | 17/2311 | 44/18723 | 8.57e-06 | 1.97e-04 | 17 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0514514 | Cervix | CC | Toxoplasmosis | 34/1267 | 112/8465 | 2.42e-05 | 1.82e-04 | 1.08e-04 | 34 |
| hsa0514515 | Cervix | CC | Toxoplasmosis | 34/1267 | 112/8465 | 2.42e-05 | 1.82e-04 | 1.08e-04 | 34 |
| hsa0514522 | Cervix | HSIL_HPV | Toxoplasmosis | 22/459 | 112/8465 | 1.07e-07 | 3.14e-06 | 2.54e-06 | 22 |
| hsa0514532 | Cervix | HSIL_HPV | Toxoplasmosis | 22/459 | 112/8465 | 1.07e-07 | 3.14e-06 | 2.54e-06 | 22 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ALOX5 | SNV | Missense_Mutation | c.1112N>A | p.Arg371Gln | p.R371Q | P09917 | protein_coding | tolerated(0.21) | benign(0.03) | TCGA-GM-A3NW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
| ALOX5 | insertion | In_Frame_Ins | novel | c.230_231insAAACTG | p.Asn78_Asp79insTrpAsn | p.N78_D79insWN | P09917 | protein_coding | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| ALOX5 | insertion | Nonsense_Mutation | novel | c.211_212insCTTCAACTTCCCAACCTTGATGAAAAGAGTGTT | p.Glu71delinsAlaSerThrSerGlnProTerTerLysGluCysTer | p.E71delinsASTSQP**KEC* | P09917 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| ALOX5 | insertion | Nonsense_Mutation | novel | c.323_324insGTGA | p.Glu109Ter | p.E109* | P09917 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
| ALOX5 | insertion | Frame_Shift_Ins | novel | c.324_325insAAATTCTTAACACCTCCAGAACAAAGGCTCAG | p.Glu109LysfsTer15 | p.E109Kfs*15 | P09917 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
| ALOX5 | SNV | Missense_Mutation | rs778612367 | c.431G>A | p.Arg144Gln | p.R144Q | P09917 | protein_coding | deleterious(0.03) | possibly_damaging(0.764) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ALOX5 | SNV | Missense_Mutation | novel | c.106C>T | p.His36Tyr | p.H36Y | P09917 | protein_coding | tolerated(0.41) | possibly_damaging(0.792) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ALOX5 | SNV | Missense_Mutation | c.883N>A | p.Ala295Thr | p.A295T | P09917 | protein_coding | tolerated(0.42) | benign(0.187) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| ALOX5 | SNV | Missense_Mutation | c.685N>A | p.Glu229Lys | p.E229K | P09917 | protein_coding | deleterious(0.01) | benign(0.044) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ALOX5 | SNV | Missense_Mutation | novel | c.517N>A | p.Glu173Lys | p.E173K | P09917 | protein_coding | tolerated(0.17) | possibly_damaging(0.771) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | SKF-105809 | |||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | MESALAZINE | MESALAMINE | ||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | 6-DECYLSALICYLIC ACID | CHEMBL416038 | 24231650 | |
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | Rilopirox | RILOPIROX | ||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | SELENIUM | 14975747 | ||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | MECLOFENAMIC ACID | |||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | ZILEUTON | ZILEUTON | ||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL421 | SULFASALAZINE | |
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | ZILEUTON | ZILEUTON | ||
| 240 | ALOX5 | DRUGGABLE GENOME, ENZYME | inhibitor | 375973266 |
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