Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ALOX15B

Gene summary for ALOX15B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ALOX15B

Gene ID

247

Gene namearachidonate 15-lipoxygenase type B
Gene Alias15-LOX-2
Cytomap17p13.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O15296


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
247ALOX15BP11T-EHumanEsophagusESCC7.73e-167.25e-010.1426
247ALOX15BP20T-EHumanEsophagusESCC3.20e-071.82e-010.1124
247ALOX15BP38T-EHumanEsophagusESCC1.00e-031.87e-010.127
247ALOX15BP47T-EHumanEsophagusESCC3.50e-021.20e-010.1067
247ALOX15BP62T-EHumanEsophagusESCC6.87e-134.35e-010.1302
247ALOX15BP65T-EHumanEsophagusESCC9.96e-191.20e+000.0978
247ALOX15BP74T-EHumanEsophagusESCC2.11e-102.80e-010.1479
247ALOX15BP79T-EHumanEsophagusESCC2.06e-081.81e-010.1154
247ALOX15BC51HumanOral cavityOSCC3.11e-022.89e-010.2674
247ALOX15BC06HumanOral cavityOSCC4.37e-071.21e+000.2699
247ALOX15BLP15HumanOral cavityLP3.25e-026.63e-010.2174
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0048732111EsophagusESCCgland development269/8552436/187237.81e-122.95e-10269
GO:00457865EsophagusESCCnegative regulation of cell cycle236/8552385/187233.62e-109.93e-09236
GO:0030522110EsophagusESCCintracellular receptor signaling pathway170/8552265/187238.58e-102.09e-08170
GO:00435888EsophagusESCCskin development163/8552263/187236.48e-081.14e-06163
GO:0061458110EsophagusESCCreproductive system development247/8552427/187232.24e-073.42e-06247
GO:004860818EsophagusESCCreproductive structure development245/8552424/187232.82e-074.14e-06245
GO:000854410EsophagusESCCepidermis development193/8552324/187232.87e-074.19e-06193
GO:00066446EsophagusESCCphospholipid metabolic process218/8552383/187235.37e-065.59e-05218
GO:00459267EsophagusESCCnegative regulation of growth148/8552249/187237.88e-067.73e-05148
GO:000991310EsophagusESCCepidermal cell differentiation122/8552202/187231.69e-051.51e-04122
GO:00344407EsophagusESCClipid oxidation71/8552108/187232.00e-051.74e-0471
GO:00456826EsophagusESCCregulation of epidermis development46/855265/187233.65e-052.97e-0446
GO:00066318EsophagusESCCfatty acid metabolic process217/8552390/187234.21e-053.39e-04217
GO:00302167EsophagusESCCkeratinocyte differentiation86/8552139/187238.53e-056.19e-0486
GO:00456046EsophagusESCCregulation of epidermal cell differentiation41/855258/187231.00e-047.10e-0441
GO:00463948EsophagusESCCcarboxylic acid biosynthetic process175/8552314/187231.98e-041.26e-03175
GO:00160538EsophagusESCCorganic acid biosynthetic process175/8552316/187233.04e-041.82e-03175
GO:00308506EsophagusESCCprostate gland development32/855245/187234.87e-042.70e-0332
GO:00456167EsophagusESCCregulation of keratinocyte differentiation26/855237/187232.16e-039.62e-0326
GO:000181916EsophagusESCCpositive regulation of cytokine production244/8552467/187232.29e-031.01e-02244
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ALOX15BSNVMissense_Mutationc.1732N>Tp.Pro578Serp.P578SO15296protein_codingdeleterious(0.01)probably_damaging(0.967)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ALOX15BSNVMissense_Mutationrs759189692c.701N>Gp.Glu234Glyp.E234GO15296protein_codingdeleterious(0)probably_damaging(0.994)TCGA-AQ-A04H-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
ALOX15BSNVMissense_Mutationc.150N>Tp.Glu50Aspp.E50DO15296protein_codingtolerated(0.36)benign(0.024)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ALOX15BSNVMissense_Mutationrs867086223c.50N>Ap.Gly17Aspp.G17DO15296protein_codingdeleterious(0)probably_damaging(0.991)TCGA-BH-A1F6-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
ALOX15BSNVMissense_Mutationrs771462763c.1900N>Tp.Arg634Trpp.R634WO15296protein_codingdeleterious(0.01)benign(0.173)TCGA-E2-A1IO-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydocetaxelSD
ALOX15BinsertionFrame_Shift_Insnovelc.613_614insACTTTAATTGCAAATTTTTCTTTp.Gly205AspfsTer14p.G205Dfs*14O15296protein_codingTCGA-A2-A0D1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapytaxotereSD
ALOX15BdeletionFrame_Shift_Delnovelc.810_811delNNp.Leu272GlyfsTer9p.L272Gfs*9O15296protein_codingTCGA-JL-A3YW-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ALOX15BSNVMissense_Mutationc.882N>Gp.Ile294Metp.I294MO15296protein_codingdeleterious(0.02)possibly_damaging(0.491)TCGA-C5-A1BK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ALOX15BSNVMissense_Mutationc.1540N>Cp.Glu514Glnp.E514QO15296protein_codingdeleterious(0)probably_damaging(0.976)TCGA-EK-A2RK-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
ALOX15BSNVMissense_Mutationnovelc.1564N>Cp.Asn522Hisp.N522HO15296protein_codingdeleterious(0)benign(0.146)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
247ALOX15BDRUGGABLE GENOME, ENZYMEE324E324
247ALOX15BDRUGGABLE GENOME, ENZYMEDIENESTROLDIENESTROL
247ALOX15BDRUGGABLE GENOME, ENZYME3,3',4'-TRIHYDROXYFLAVONECHEMBL122701
247ALOX15BDRUGGABLE GENOME, ENZYMECAPSAZEPINECAPSAZEPINE
247ALOX15BDRUGGABLE GENOME, ENZYMEHEXACHLOROPHENEHEXACHLOROPHENE
247ALOX15BDRUGGABLE GENOME, ENZYMENORDIHYDROGUAIARETIC ACIDNORDIHYDROGUAIARETIC ACID
247ALOX15BDRUGGABLE GENOME, ENZYMETYRPHOSTIN AG 879TYRPHOSTIN AG 879
247ALOX15BDRUGGABLE GENOME, ENZYMEN,N'-DIPHENYL-P-PHENYLENEDIAMINEN,N'-DIPHENYL-P-PHENYLENEDIAMINE
247ALOX15BDRUGGABLE GENOME, ENZYMENSC-632536CHEMBL1367933
247ALOX15BDRUGGABLE GENOME, ENZYMEDIHYDROXIDINEDIHYDROXIDINE
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