Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ALOX15

Gene summary for ALOX15

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ALOX15

Gene ID

246

Gene namearachidonate 15-lipoxygenase
Gene Alias12-LOX
Cytomap17p13.2
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

P16050


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
246ALOX15LZE2THumanEsophagusESCC5.44e-106.52e-010.082
246ALOX15LZE5THumanEsophagusESCC1.57e-022.22e-010.0514
246ALOX15LZE24THumanEsophagusESCC6.29e-041.57e-010.0596
246ALOX15LZE21THumanEsophagusESCC9.73e-055.09e-010.0655
246ALOX15P4T-EHumanEsophagusESCC8.00e-031.77e-010.1323
246ALOX15P8T-EHumanEsophagusESCC9.78e-308.66e-010.0889
246ALOX15P12T-EHumanEsophagusESCC4.31e-062.73e-010.1122
246ALOX15P15T-EHumanEsophagusESCC2.65e-196.90e-010.1149
246ALOX15P20T-EHumanEsophagusESCC3.20e-072.14e-010.1124
246ALOX15P22T-EHumanEsophagusESCC2.02e-061.49e-010.1236
246ALOX15P26T-EHumanEsophagusESCC2.78e-388.26e-010.1276
246ALOX15P27T-EHumanEsophagusESCC4.16e-225.12e-010.1055
246ALOX15P30T-EHumanEsophagusESCC4.44e-042.29e-010.137
246ALOX15P62T-EHumanEsophagusESCC1.44e-175.17e-010.1302
246ALOX15P65T-EHumanEsophagusESCC3.23e-153.99e-010.0978
246ALOX15P74T-EHumanEsophagusESCC3.33e-124.59e-010.1479
246ALOX15P75T-EHumanEsophagusESCC3.52e-195.30e-010.1125
246ALOX15P84T-EHumanEsophagusESCC1.06e-032.67e-010.0933
246ALOX15P127T-EHumanEsophagusESCC7.76e-041.65e-010.0826
246ALOX15P128T-EHumanEsophagusESCC9.55e-031.47e-010.1241
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0034976111EsophagusESCCresponse to endoplasmic reticulum stress192/8552256/187237.15e-221.30e-19192
GO:0043254111EsophagusESCCregulation of protein-containing complex assembly278/8552428/187233.81e-162.77e-14278
GO:0031334111EsophagusESCCpositive regulation of protein-containing complex assembly166/8552237/187232.06e-141.07e-12166
GO:0048732111EsophagusESCCgland development269/8552436/187237.81e-122.95e-10269
GO:1902905111EsophagusESCCpositive regulation of supramolecular fiber organization142/8552209/187235.51e-111.76e-09142
GO:1902903111EsophagusESCCregulation of supramolecular fiber organization237/8552383/187239.06e-112.75e-09237
GO:00457865EsophagusESCCnegative regulation of cell cycle236/8552385/187233.62e-109.93e-09236
GO:0030522110EsophagusESCCintracellular receptor signaling pathway170/8552265/187238.58e-102.09e-08170
GO:00086544EsophagusESCCphospholipid biosynthetic process162/8552253/187232.59e-095.73e-08162
GO:005149520EsophagusESCCpositive regulation of cytoskeleton organization147/8552226/187232.93e-096.38e-08147
GO:003158919EsophagusESCCcell-substrate adhesion221/8552363/187233.06e-096.62e-08221
GO:001081020EsophagusESCCregulation of cell-substrate adhesion144/8552221/187233.55e-097.45e-08144
GO:0051258111EsophagusESCCprotein polymerization183/8552297/187231.94e-083.75e-07183
GO:000701527EsophagusESCCactin filament organization259/8552442/187232.37e-084.50e-07259
GO:0032273111EsophagusESCCpositive regulation of protein polymerization95/8552138/187232.97e-085.57e-0795
GO:003253520EsophagusESCCregulation of cellular component size227/8552383/187234.77e-088.60e-07227
GO:004578527EsophagusESCCpositive regulation of cell adhesion255/8552437/187235.07e-089.11e-07255
GO:003010018EsophagusESCCregulation of endocytosis135/8552211/187235.75e-081.02e-06135
GO:00464744EsophagusESCCglycerophospholipid biosynthetic process135/8552211/187235.75e-081.02e-06135
GO:00435888EsophagusESCCskin development163/8552263/187236.48e-081.14e-06163
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ALOX15SNVMissense_Mutationnovelc.1196N>Ap.Ile399Asnp.I399NP16050protein_codingdeleterious(0)probably_damaging(0.997)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
ALOX15SNVMissense_Mutationc.948N>Gp.Ile316Metp.I316MP16050protein_codingdeleterious(0)probably_damaging(0.911)TCGA-A7-A26F-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
ALOX15SNVMissense_Mutationnovelc.1747T>Cp.Phe583Leup.F583LP16050protein_codingtolerated(0.59)benign(0.003)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
ALOX15SNVMissense_Mutationc.1621N>Ap.Ala541Thrp.A541TP16050protein_codingdeleterious(0.02)benign(0.109)TCGA-E2-A1LK-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownPD
ALOX15insertionFrame_Shift_Insnovelc.1850_1851insATCACTTGGCAGCTGGGCAGACGCCAGCCCGTTAp.Glu618SerfsTer12p.E618Sfs*12P16050protein_codingTCGA-A8-A085-01Breastbreast invasive carcinomaMale<65I/IIHormone TherapytamoxiphenSD
ALOX15SNVMissense_Mutationrs143365387c.1056N>Ap.Phe352Leup.F352LP16050protein_codingdeleterious(0.02)benign(0.257)TCGA-AA-3496-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ALOX15SNVMissense_Mutationnovelc.857C>Tp.Ala286Valp.A286VP16050protein_codingdeleterious(0.03)possibly_damaging(0.62)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
ALOX15SNVMissense_Mutationrs760254381c.862N>Ap.Val288Ilep.V288IP16050protein_codingtolerated(0.15)benign(0.006)TCGA-CM-6674-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
ALOX15SNVMissense_Mutationrs763395191c.1345N>Ap.Asp449Asnp.D449NP16050protein_codingdeleterious(0.05)benign(0.255)TCGA-G4-6304-01Colorectumcolon adenocarcinomaFemale>=65I/IIChemotherapyfluorouracilPD
ALOX15SNVMissense_Mutationrs139214774c.271N>Ap.Glu91Lysp.E91KP16050protein_codingtolerated(0.19)benign(0.009)TCGA-AG-3731-01Colorectumrectum adenocarcinomaMale>=65III/IVChemotherapyfolinicPR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
246ALOX15ENZYME, DRUGGABLE GENOMEinhibitor381744944
246ALOX15ENZYME, DRUGGABLE GENOMEFEXOFENADINE HYDROCHLORIDEFEXOFENADINE HYDROCHLORIDE
246ALOX15ENZYME, DRUGGABLE GENOMECAFFEIC ACID PHENETHYL ESTERCAFFEIC ACID PHENETHYL ESTER
246ALOX15ENZYME, DRUGGABLE GENOMEATHRAQUINONES AATHRAQUINONES A
246ALOX15ENZYME, DRUGGABLE GENOMEQUINOXALINE-2-CARBOXYLIC ACIDCHEMBL151797
246ALOX15ENZYME, DRUGGABLE GENOMEMERCURIC CHLORIDEMERCURIC CHLORIDE
246ALOX15ENZYME, DRUGGABLE GENOMECISPLATINCISPLATIN
246ALOX15ENZYME, DRUGGABLE GENOMEEHNAEHNA
246ALOX15ENZYME, DRUGGABLE GENOME3,4-DIDESMETHYL-5-DESHYDROXY-3'-ETHOXYSCLEROIN3,4-DIDESMETHYL-5-DESHYDROXY-3'-ETHOXYSCLEROIN
246ALOX15ENZYME, DRUGGABLE GENOMEDITHIOLETHIONEDITHIOLETHIONE
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