|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ALKBH3 |
Gene summary for ALKBH3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ALKBH3 | Gene ID | 221120 |
| Gene name | alkB homolog 3, alpha-ketoglutarate dependent dioxygenase | |
| Gene Alias | ABH3 | |
| Cytomap | 11p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96Q83 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 221120 | ALKBH3 | LZE4T | Human | Esophagus | ESCC | 5.59e-07 | 2.28e-01 | 0.0811 |
| 221120 | ALKBH3 | LZE7T | Human | Esophagus | ESCC | 3.30e-04 | 2.99e-01 | 0.0667 |
| 221120 | ALKBH3 | LZE22T | Human | Esophagus | ESCC | 2.29e-02 | 1.70e-01 | 0.068 |
| 221120 | ALKBH3 | LZE24T | Human | Esophagus | ESCC | 1.92e-17 | 4.15e-01 | 0.0596 |
| 221120 | ALKBH3 | LZE6T | Human | Esophagus | ESCC | 4.68e-03 | 1.99e-01 | 0.0845 |
| 221120 | ALKBH3 | P1T-E | Human | Esophagus | ESCC | 1.31e-03 | 2.61e-01 | 0.0875 |
| 221120 | ALKBH3 | P2T-E | Human | Esophagus | ESCC | 1.51e-24 | 4.51e-01 | 0.1177 |
| 221120 | ALKBH3 | P4T-E | Human | Esophagus | ESCC | 5.80e-14 | 2.45e-01 | 0.1323 |
| 221120 | ALKBH3 | P5T-E | Human | Esophagus | ESCC | 1.10e-02 | 7.12e-02 | 0.1327 |
| 221120 | ALKBH3 | P8T-E | Human | Esophagus | ESCC | 7.33e-20 | 3.43e-01 | 0.0889 |
| 221120 | ALKBH3 | P9T-E | Human | Esophagus | ESCC | 3.09e-07 | 1.82e-01 | 0.1131 |
| 221120 | ALKBH3 | P10T-E | Human | Esophagus | ESCC | 1.98e-21 | 3.25e-01 | 0.116 |
| 221120 | ALKBH3 | P11T-E | Human | Esophagus | ESCC | 3.15e-13 | 4.86e-01 | 0.1426 |
| 221120 | ALKBH3 | P12T-E | Human | Esophagus | ESCC | 1.44e-23 | 2.98e-01 | 0.1122 |
| 221120 | ALKBH3 | P15T-E | Human | Esophagus | ESCC | 1.04e-19 | 2.63e-01 | 0.1149 |
| 221120 | ALKBH3 | P16T-E | Human | Esophagus | ESCC | 6.12e-20 | 3.41e-01 | 0.1153 |
| 221120 | ALKBH3 | P17T-E | Human | Esophagus | ESCC | 1.16e-11 | 3.90e-01 | 0.1278 |
| 221120 | ALKBH3 | P19T-E | Human | Esophagus | ESCC | 7.89e-07 | 4.39e-01 | 0.1662 |
| 221120 | ALKBH3 | P20T-E | Human | Esophagus | ESCC | 7.97e-30 | 4.80e-01 | 0.1124 |
| 221120 | ALKBH3 | P21T-E | Human | Esophagus | ESCC | 4.42e-29 | 5.86e-01 | 0.1617 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
| GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
| GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ALKBH3 | SNV | Missense_Mutation | c.718N>A | p.Asp240Asn | p.D240N | Q96Q83 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | |
| ALKBH3 | SNV | Missense_Mutation | c.773N>A | p.Arg258Gln | p.R258Q | Q96Q83 | protein_coding | tolerated(0.15) | benign(0.088) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| ALKBH3 | SNV | Missense_Mutation | rs202134415 | c.476N>A | p.Arg159His | p.R159H | Q96Q83 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | novel | c.728C>T | p.Thr243Ile | p.T243I | Q96Q83 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | rs542847003 | c.290N>C | p.Val97Ala | p.V97A | Q96Q83 | protein_coding | deleterious(0) | possibly_damaging(0.493) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | rs745683816 | c.749N>T | p.Ala250Val | p.A250V | Q96Q83 | protein_coding | deleterious(0.01) | possibly_damaging(0.596) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | c.760N>A | p.Asp254Asn | p.D254N | Q96Q83 | protein_coding | deleterious(0.01) | possibly_damaging(0.675) | TCGA-A5-A0G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ALKBH3 | SNV | Missense_Mutation | rs762849148 | c.209N>A | p.Arg70Gln | p.R70Q | Q96Q83 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | novel | c.506N>T | p.Thr169Ile | p.T169I | Q96Q83 | protein_coding | deleterious(0.02) | benign(0.266) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ALKBH3 | SNV | Missense_Mutation | c.641N>T | p.Thr214Ile | p.T214I | Q96Q83 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |