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Gene: ALDH7A1 |
Gene summary for ALDH7A1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ALDH7A1 | Gene ID | 501 |
| Gene name | aldehyde dehydrogenase 7 family member A1 | |
| Gene Alias | ATQ1 | |
| Cytomap | 5q23.2 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P49419 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 501 | ALDH7A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.67e-03 | 2.73e-01 | 0.0155 |
| 501 | ALDH7A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.65e-03 | 5.23e-01 | -0.0811 |
| 501 | ALDH7A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.58e-07 | 5.06e-01 | -0.1954 |
| 501 | ALDH7A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.36e-05 | 3.26e-01 | -0.1464 |
| 501 | ALDH7A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.00e-15 | 5.40e-01 | 0.0674 |
| 501 | ALDH7A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.88e-04 | 3.19e-01 | 0.294 |
| 501 | ALDH7A1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.04e-02 | 3.04e-01 | 0.281 |
| 501 | ALDH7A1 | A015-C-203 | Human | Colorectum | FAP | 9.51e-08 | -1.98e-01 | -0.1294 |
| 501 | ALDH7A1 | A002-C-201 | Human | Colorectum | FAP | 2.42e-03 | -2.09e-01 | 0.0324 |
| 501 | ALDH7A1 | A001-C-108 | Human | Colorectum | FAP | 6.12e-05 | -1.42e-01 | -0.0272 |
| 501 | ALDH7A1 | A002-C-205 | Human | Colorectum | FAP | 1.01e-04 | -1.71e-01 | -0.1236 |
| 501 | ALDH7A1 | A015-C-006 | Human | Colorectum | FAP | 4.94e-04 | -2.32e-01 | -0.0994 |
| 501 | ALDH7A1 | A002-C-114 | Human | Colorectum | FAP | 3.51e-05 | -2.45e-01 | -0.1561 |
| 501 | ALDH7A1 | A015-C-104 | Human | Colorectum | FAP | 5.24e-06 | -1.77e-01 | -0.1899 |
| 501 | ALDH7A1 | A002-C-016 | Human | Colorectum | FAP | 1.77e-07 | -1.92e-01 | 0.0521 |
| 501 | ALDH7A1 | A015-C-002 | Human | Colorectum | FAP | 5.54e-04 | -3.12e-01 | -0.0763 |
| 501 | ALDH7A1 | A001-C-203 | Human | Colorectum | FAP | 1.86e-02 | -1.22e-01 | -0.0481 |
| 501 | ALDH7A1 | A002-C-116 | Human | Colorectum | FAP | 2.03e-09 | -2.41e-01 | -0.0452 |
| 501 | ALDH7A1 | A018-E-020 | Human | Colorectum | FAP | 1.15e-03 | -1.15e-01 | -0.2034 |
| 501 | ALDH7A1 | F034 | Human | Colorectum | FAP | 4.55e-04 | -6.30e-02 | -0.0665 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
| GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
| GO:0042398 | Colorectum | AD | cellular modified amino acid biosynthetic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
| GO:00423981 | Colorectum | MSS | cellular modified amino acid biosynthetic process | 20/3467 | 46/18723 | 8.26e-05 | 1.35e-03 | 20 |
| GO:00065751 | Colorectum | MSS | cellular modified amino acid metabolic process | 55/3467 | 188/18723 | 2.16e-04 | 3.01e-03 | 55 |
| GO:00060811 | Colorectum | MSS | cellular aldehyde metabolic process | 21/3467 | 60/18723 | 1.81e-03 | 1.60e-02 | 21 |
| GO:00423983 | Colorectum | FAP | cellular modified amino acid biosynthetic process | 13/2622 | 46/18723 | 8.71e-03 | 4.98e-02 | 13 |
| GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
| GO:00423986 | Esophagus | ESCC | cellular modified amino acid biosynthetic process | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
| GO:00060818 | Esophagus | ESCC | cellular aldehyde metabolic process | 40/8552 | 60/18723 | 8.30e-04 | 4.28e-03 | 40 |
| GO:004239811 | Liver | Cirrhotic | cellular modified amino acid biosynthetic process | 25/4634 | 46/18723 | 1.61e-05 | 2.19e-04 | 25 |
| GO:000657511 | Liver | Cirrhotic | cellular modified amino acid metabolic process | 70/4634 | 188/18723 | 9.04e-05 | 9.69e-04 | 70 |
| GO:00060815 | Liver | Cirrhotic | cellular aldehyde metabolic process | 28/4634 | 60/18723 | 1.83e-04 | 1.71e-03 | 28 |
| GO:00424021 | Liver | Cirrhotic | cellular biogenic amine catabolic process | 15/4634 | 27/18723 | 5.96e-04 | 4.63e-03 | 15 |
| GO:0044106 | Liver | Cirrhotic | cellular amine metabolic process | 43/4634 | 113/18723 | 1.15e-03 | 7.83e-03 | 43 |
| GO:00093101 | Liver | Cirrhotic | amine catabolic process | 15/4634 | 29/18723 | 1.59e-03 | 1.03e-02 | 15 |
| GO:0006576 | Liver | Cirrhotic | cellular biogenic amine metabolic process | 38/4634 | 101/18723 | 2.72e-03 | 1.59e-02 | 38 |
| GO:0009308 | Liver | Cirrhotic | amine metabolic process | 43/4634 | 118/18723 | 3.03e-03 | 1.72e-02 | 43 |
| GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
| GO:004239821 | Liver | HCC | cellular modified amino acid biosynthetic process | 34/7958 | 46/18723 | 1.53e-05 | 1.67e-04 | 34 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
| hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
| hsa00280 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
| hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
| hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
| hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
| hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
| hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
| hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
| hsa002801 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
| hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
| hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
| hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
| hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
| hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
| hsa003304 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
| hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
| hsa002802 | Colorectum | MSS | Valine, leucine and isoleucine degradation | 21/1875 | 48/8465 | 6.73e-04 | 4.51e-03 | 2.76e-03 | 21 |
| hsa003102 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
| hsa005612 | Colorectum | MSS | Glycerolipid metabolism | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
| Page: 1 2 3 4 5 6 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ALDH7A1 | SNV | Missense_Mutation | c.1280A>G | p.Glu427Gly | p.E427G | P49419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ALDH7A1 | SNV | Missense_Mutation | c.814T>C | p.Phe272Leu | p.F272L | P49419 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ALDH7A1 | SNV | Missense_Mutation | c.586T>C | p.Phe196Leu | p.F196L | P49419 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ALDH7A1 | SNV | Missense_Mutation | rs771975420 | c.1211G>A | p.Arg404His | p.R404H | P49419 | protein_coding | tolerated(0.05) | benign(0.034) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ALDH7A1 | SNV | Missense_Mutation | rs765795361 | c.1063N>A | p.Ala355Thr | p.A355T | P49419 | protein_coding | tolerated(0.29) | benign(0.04) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ALDH7A1 | SNV | Missense_Mutation | novel | c.1559C>T | p.Ser520Phe | p.S520F | P49419 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ALDH7A1 | SNV | Missense_Mutation | rs752533662 | c.673N>T | p.Leu225Phe | p.L225F | P49419 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
| ALDH7A1 | insertion | Frame_Shift_Ins | novel | c.1517_1518insA | p.Glu507GlyfsTer5 | p.E507Gfs*5 | P49419 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ALDH7A1 | insertion | Nonsense_Mutation | novel | c.1516_1517insAATAGATACTTA | p.Gly505_Arg506insLysTerIleLeu | p.G505_R506insK*IL | P49419 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ALDH7A1 | SNV | Missense_Mutation | novel | c.784G>A | p.Ala262Thr | p.A262T | P49419 | protein_coding | tolerated(0.27) | benign(0.08) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 501 | ALDH7A1 | ENZYME, DRUGGABLE GENOME | M-518101 | PEFCALCITOL | ||
| 501 | ALDH7A1 | ENZYME, DRUGGABLE GENOME | NM-702 |
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