Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ALDH3A2

Gene summary for ALDH3A2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ALDH3A2

Gene ID

224

Gene namealdehyde dehydrogenase 3 family member A2
Gene AliasALDH10
Cytomap17p11.2
Gene Typeprotein-coding
GO ID

GO:0006066

UniProtAcc

P51648


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
224ALDH3A2HTA11_347_2000001011HumanColorectumAD6.49e-063.58e-01-0.1954
224ALDH3A2HTA11_546_2000001011HumanColorectumAD2.25e-021.90e-01-0.0842
224ALDH3A2HTA11_99999970781_79442HumanColorectumMSS3.08e-021.89e-010.294
224ALDH3A2A015-C-203HumanColorectumFAP6.51e-07-1.26e-01-0.1294
224ALDH3A2A001-C-108HumanColorectumFAP6.39e-031.59e-02-0.0272
224ALDH3A2A002-C-205HumanColorectumFAP2.37e-02-8.40e-02-0.1236
224ALDH3A2A015-C-006HumanColorectumFAP3.24e-021.52e-02-0.0994
224ALDH3A2A002-C-114HumanColorectumFAP2.24e-02-1.60e-01-0.1561
224ALDH3A2A015-C-104HumanColorectumFAP1.76e-09-1.21e-02-0.1899
224ALDH3A2A001-C-014HumanColorectumFAP9.00e-03-1.45e-010.0135
224ALDH3A2A002-C-016HumanColorectumFAP6.45e-03-1.69e-010.0521
224ALDH3A2A002-C-116HumanColorectumFAP4.00e-09-1.80e-01-0.0452
224ALDH3A2A018-E-020HumanColorectumFAP2.48e-03-1.65e-01-0.2034
224ALDH3A2F034HumanColorectumFAP8.56e-05-1.50e-01-0.0665
224ALDH3A2CRC-3-11773HumanColorectumCRC1.87e-02-1.87e-010.2564
224ALDH3A2LZE4THumanEsophagusESCC9.31e-107.77e-010.0811
224ALDH3A2LZE7THumanEsophagusESCC1.40e-025.36e-010.0667
224ALDH3A2LZE8THumanEsophagusESCC9.41e-11-4.93e-020.067
224ALDH3A2LZE20THumanEsophagusESCC1.50e-12-3.57e-010.0662
224ALDH3A2LZE22D1HumanEsophagusHGIN3.10e-07-1.86e-010.0595
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006066ColorectumADalcohol metabolic process106/3918353/187233.02e-055.57e-04106
GO:0006631ColorectumADfatty acid metabolic process114/3918390/187235.58e-059.44e-04114
GO:0034308ColorectumADprimary alcohol metabolic process35/3918102/187231.16e-031.05e-0235
GO:0006081ColorectumADcellular aldehyde metabolic process22/391860/187233.64e-032.60e-0222
GO:0008544ColorectumADepidermis development87/3918324/187235.99e-033.76e-0287
GO:00060662ColorectumMSSalcohol metabolic process92/3467353/187232.57e-043.46e-0392
GO:00060811ColorectumMSScellular aldehyde metabolic process21/346760/187231.81e-031.60e-0221
GO:00066312ColorectumMSSfatty acid metabolic process95/3467390/187232.20e-031.84e-0295
GO:00066313ColorectumFAPfatty acid metabolic process81/2622390/187231.43e-042.24e-0381
GO:00085441ColorectumFAPepidermis development66/2622324/187239.63e-049.51e-0366
GO:00060663ColorectumFAPalcohol metabolic process69/2622353/187232.29e-031.85e-0269
GO:00085442ColorectumCRCepidermis development57/2078324/187232.88e-044.59e-0357
GO:00066314ColorectumCRCfatty acid metabolic process65/2078390/187235.30e-047.42e-0365
GO:00060664ColorectumCRCalcohol metabolic process57/2078353/187232.37e-032.27e-0257
GO:000854410EsophagusESCCepidermis development193/8552324/187232.87e-074.19e-06193
GO:00060668EsophagusESCCalcohol metabolic process202/8552353/187237.32e-067.26e-05202
GO:00066318EsophagusESCCfatty acid metabolic process217/8552390/187234.21e-053.39e-04217
GO:00060818EsophagusESCCcellular aldehyde metabolic process40/855260/187238.30e-044.28e-0340
GO:000663112LiverCirrhoticfatty acid metabolic process165/4634390/187231.29e-141.26e-12165
GO:000606612LiverCirrhoticalcohol metabolic process141/4634353/187231.57e-108.03e-09141
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00620ColorectumADPyruvate metabolism28/209247/84653.71e-075.41e-063.45e-0628
hsa00010ColorectumADGlycolysis / Gluconeogenesis34/209267/84653.63e-064.34e-052.77e-0534
hsa00280ColorectumADValine, leucine and isoleucine degradation25/209248/84653.97e-053.41e-042.18e-0425
hsa00330ColorectumADArginine and proline metabolism23/209250/84658.27e-045.90e-033.76e-0323
hsa00310ColorectumADLysine degradation27/209263/84651.17e-037.75e-034.94e-0327
hsa00071ColorectumADFatty acid degradation20/209243/84651.50e-038.69e-035.54e-0320
hsa00561ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa006201ColorectumADPyruvate metabolism28/209247/84653.71e-075.41e-063.45e-0628
hsa000101ColorectumADGlycolysis / Gluconeogenesis34/209267/84653.63e-064.34e-052.77e-0534
hsa002801ColorectumADValine, leucine and isoleucine degradation25/209248/84653.97e-053.41e-042.18e-0425
hsa003301ColorectumADArginine and proline metabolism23/209250/84658.27e-045.90e-033.76e-0323
hsa003101ColorectumADLysine degradation27/209263/84651.17e-037.75e-034.94e-0327
hsa000711ColorectumADFatty acid degradation20/209243/84651.50e-038.69e-035.54e-0320
hsa005611ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa006204ColorectumMSSPyruvate metabolism24/187547/84651.25e-051.35e-048.27e-0524
hsa003304ColorectumMSSArginine and proline metabolism23/187550/84651.52e-041.24e-037.61e-0423
hsa000104ColorectumMSSGlycolysis / Gluconeogenesis28/187567/84652.36e-041.81e-031.11e-0328
hsa002802ColorectumMSSValine, leucine and isoleucine degradation21/187548/84656.73e-044.51e-032.76e-0321
hsa003102ColorectumMSSLysine degradation24/187563/84652.94e-031.39e-028.50e-0324
hsa005612ColorectumMSSGlycerolipid metabolism23/187563/84656.55e-032.64e-021.62e-0223
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ALDH3A2SNVMissense_Mutationc.587N>Tp.Ala196Valp.A196VP51648protein_codingdeleterious(0.03)probably_damaging(0.997)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ALDH3A2SNVMissense_Mutationrs778115541c.1234G>Ap.Gly412Argp.G412RP51648protein_codingdeleterious(0)probably_damaging(0.999)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
ALDH3A2insertionNonsense_Mutationnovelc.1305_1306insTGGGTGTGTGGGGCCATGGATGAATGAAGCCACATGGGATGGTGGGp.Asn436TrpfsTer9p.N436Wfs*9P51648protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
ALDH3A2insertionFrame_Shift_Insnovelc.1401_1402insCCCGGCCCCCTCCCTCAp.Leu468ProfsTer14p.L468Pfs*14P51648protein_codingTCGA-AO-A0JM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
ALDH3A2SNVMissense_Mutationc.964G>Cp.Asp322Hisp.D322HP51648protein_codingdeleterious(0.02)possibly_damaging(0.477)TCGA-IR-A3LF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ALDH3A2SNVMissense_Mutationc.331T>Cp.Trp111Argp.W111RP51648protein_codingdeleterious(0.02)probably_damaging(0.997)TCGA-Q1-A6DW-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
ALDH3A2SNVMissense_Mutationnovelc.1356N>Tp.Lys452Asnp.K452NP51648protein_codingtolerated(0.13)benign(0.01)TCGA-A6-6141-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapy5-fuSD
ALDH3A2SNVMissense_Mutationc.1276N>Gp.Leu426Valp.L426VP51648protein_codingdeleterious(0.03)probably_damaging(0.923)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ALDH3A2SNVMissense_Mutationnovelc.1253N>Tp.Thr418Ilep.T418IP51648protein_codingdeleterious(0.01)benign(0.151)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
ALDH3A2SNVMissense_Mutationrs72547562c.551N>Tp.Thr184Metp.T184MP51648protein_codingdeleterious(0)probably_damaging(1)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
224ALDH3A2DRUGGABLE GENOME, ENZYMEDisulfiramDISULFIRAM
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