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Gene: AKR1B15 |
Gene summary for AKR1B15 |
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Gene information | Species | Human | Gene symbol | AKR1B15 | Gene ID | 441282 |
Gene name | aldo-keto reductase family 1 member B15 | |
Gene Alias | AKR1B10L | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | C9JRZ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441282 | AKR1B15 | S027 | Human | Liver | HCC | 1.88e-10 | 5.32e-01 | 0.2446 |
441282 | AKR1B15 | S028 | Human | Liver | HCC | 3.07e-19 | 6.20e-01 | 0.2503 |
441282 | AKR1B15 | S029 | Human | Liver | HCC | 5.83e-19 | 6.25e-01 | 0.2581 |
441282 | AKR1B15 | C30 | Human | Oral cavity | OSCC | 1.37e-03 | 2.31e-01 | 0.3055 |
441282 | AKR1B15 | C51 | Human | Oral cavity | OSCC | 1.81e-11 | 6.16e-01 | 0.2674 |
441282 | AKR1B15 | C08 | Human | Oral cavity | OSCC | 2.53e-20 | 7.35e-01 | 0.1919 |
441282 | AKR1B15 | SYSMH3 | Human | Oral cavity | OSCC | 4.27e-02 | 4.10e-02 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:00066942 | Liver | HCC | steroid biosynthetic process | 104/7958 | 173/18723 | 2.13e-06 | 2.91e-05 | 104 |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
GO:003430812 | Liver | HCC | primary alcohol metabolic process | 55/7958 | 102/18723 | 1.30e-02 | 4.67e-02 | 55 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00066945 | Oral cavity | OSCC | steroid biosynthetic process | 89/7305 | 173/18723 | 5.77e-04 | 3.30e-03 | 89 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:00082024 | Oral cavity | OSCC | steroid metabolic process | 146/7305 | 319/18723 | 7.78e-03 | 2.85e-02 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKR1B15 | insertion | Frame_Shift_Ins | novel | c.679_680insCTTTAATTGG | p.Tyr227SerfsTer23 | p.Y227Sfs*23 | C9JRZ8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AKR1B15 | insertion | Nonsense_Mutation | novel | c.790_791insGTGAGGAAAGCCTTTGAGAAGACCCTCAAGGACCTGA | p.Glu264GlyfsTer6 | p.E264Gfs*6 | C9JRZ8 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AKR1B15 | SNV | Missense_Mutation | novel | c.996C>A | p.Phe332Leu | p.F332L | C9JRZ8 | protein_coding | tolerated(0.48) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AKR1B15 | SNV | Missense_Mutation | rs149212971 | c.112N>G | p.Thr38Ala | p.T38A | C9JRZ8 | protein_coding | tolerated_low_confidence(0.43) | benign(0) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
AKR1B15 | SNV | Missense_Mutation | rs372334254 | c.835N>T | p.Arg279Cys | p.R279C | C9JRZ8 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AKR1B15 | SNV | Missense_Mutation | c.778C>A | p.Pro260Thr | p.P260T | C9JRZ8 | protein_coding | deleterious(0.03) | possibly_damaging(0.711) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AKR1B15 | SNV | Missense_Mutation | rs758195535 | c.220G>A | p.Ala74Thr | p.A74T | C9JRZ8 | protein_coding | deleterious(0.04) | possibly_damaging(0.756) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
AKR1B15 | SNV | Missense_Mutation | c.514N>A | p.Ala172Thr | p.A172T | C9JRZ8 | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
AKR1B15 | SNV | Missense_Mutation | c.568N>G | p.Phe190Val | p.F190V | C9JRZ8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
AKR1B15 | SNV | Missense_Mutation | rs781519182 | c.703N>A | p.Val235Ile | p.V235I | C9JRZ8 | protein_coding | tolerated(0.35) | benign(0.273) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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