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Gene: AKAIN1 |
Gene summary for AKAIN1 |
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Gene information | Species | Human | Gene symbol | AKAIN1 | Gene ID | 642597 |
Gene name | A-kinase anchor inhibitor 1 | |
Gene Alias | C18orf42 | |
Cytomap | 18p11.31 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | P0CW23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
642597 | AKAIN1 | S014 | Human | Liver | HCC | 2.32e-07 | 5.19e-01 | 0.2254 |
642597 | AKAIN1 | S015 | Human | Liver | HCC | 2.55e-07 | 4.75e-01 | 0.2375 |
642597 | AKAIN1 | S016 | Human | Liver | HCC | 5.11e-22 | 6.49e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKAIN1 | SNV | Missense_Mutation | novel | c.180N>A | p.Asp60Glu | p.D60E | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-A7-A425-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | PD | |
AKAIN1 | SNV | Missense_Mutation | c.121N>A | p.Val41Met | p.V41M | protein_coding | deleterious(0.03) | benign(0.377) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
AKAIN1 | SNV | Missense_Mutation | rs373261652 | c.149G>A | p.Arg50His | p.R50H | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
AKAIN1 | SNV | Missense_Mutation | rs373261652 | c.149N>A | p.Arg50His | p.R50H | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AKAIN1 | SNV | Missense_Mutation | rs775641340 | c.175C>T | p.Arg59Trp | p.R59W | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.937) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
AKAIN1 | SNV | Missense_Mutation | c.220G>A | p.Glu74Lys | p.E74K | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.961) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AKAIN1 | SNV | Missense_Mutation | c.225N>T | p.Lys75Asn | p.K75N | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.984) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
AKAIN1 | SNV | Missense_Mutation | novel | c.88N>C | p.Lys30Gln | p.K30Q | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AKAIN1 | SNV | Missense_Mutation | novel | c.131N>C | p.Val44Ala | p.V44A | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AKAIN1 | insertion | Frame_Shift_Ins | novel | c.211_212insTG | p.Lys71MetfsTer52 | p.K71Mfs*52 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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