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Gene: AJAP1 |
Gene summary for AJAP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AJAP1 | Gene ID | 55966 |
| Gene name | adherens junctions associated protein 1 | |
| Gene Alias | MOT8 | |
| Cytomap | 1p36.32 | |
| Gene Type | protein-coding | GO ID | GO:0001738 | UniProtAcc | Q9UKB5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55966 | AJAP1 | C04 | Human | Oral cavity | OSCC | 9.39e-16 | 6.45e-01 | 0.2633 |
| 55966 | AJAP1 | C30 | Human | Oral cavity | OSCC | 4.70e-11 | 6.09e-01 | 0.3055 |
| 55966 | AJAP1 | C06 | Human | Oral cavity | OSCC | 3.52e-05 | 7.60e-01 | 0.2699 |
| 55966 | AJAP1 | EOLP-1 | Human | Oral cavity | EOLP | 3.65e-04 | 2.22e-01 | -0.0202 |
| 55966 | AJAP1 | SYSMH3 | Human | Oral cavity | OSCC | 4.07e-07 | 2.72e-01 | 0.2442 |
| 55966 | AJAP1 | SYSMH5 | Human | Oral cavity | OSCC | 2.92e-05 | 2.43e-01 | 0.0647 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
| GO:003158917 | Oral cavity | OSCC | cell-substrate adhesion | 193/7305 | 363/18723 | 2.48e-08 | 4.82e-07 | 193 |
| GO:001081019 | Oral cavity | OSCC | regulation of cell-substrate adhesion | 126/7305 | 221/18723 | 4.02e-08 | 7.55e-07 | 126 |
| GO:000195215 | Oral cavity | OSCC | regulation of cell-matrix adhesion | 78/7305 | 128/18723 | 4.05e-07 | 6.02e-06 | 78 |
| GO:000716016 | Oral cavity | OSCC | cell-matrix adhesion | 125/7305 | 233/18723 | 3.76e-06 | 4.45e-05 | 125 |
| GO:190303418 | Oral cavity | OSCC | regulation of response to wounding | 87/7305 | 167/18723 | 3.91e-04 | 2.38e-03 | 87 |
| GO:00071629 | Oral cavity | OSCC | negative regulation of cell adhesion | 145/7305 | 303/18723 | 9.95e-04 | 5.18e-03 | 145 |
| GO:006104116 | Oral cavity | OSCC | regulation of wound healing | 69/7305 | 134/18723 | 2.19e-03 | 9.95e-03 | 69 |
| GO:004206026 | Oral cavity | EOLP | wound healing | 99/2218 | 422/18723 | 1.18e-11 | 1.85e-09 | 99 |
| GO:003158925 | Oral cavity | EOLP | cell-substrate adhesion | 84/2218 | 363/18723 | 8.71e-10 | 6.29e-08 | 84 |
| GO:000195216 | Oral cavity | EOLP | regulation of cell-matrix adhesion | 40/2218 | 128/18723 | 4.06e-09 | 2.39e-07 | 40 |
| GO:001081025 | Oral cavity | EOLP | regulation of cell-substrate adhesion | 57/2218 | 221/18723 | 7.77e-09 | 3.94e-07 | 57 |
| GO:000716017 | Oral cavity | EOLP | cell-matrix adhesion | 56/2218 | 233/18723 | 1.44e-07 | 4.68e-06 | 56 |
| GO:000716216 | Oral cavity | EOLP | negative regulation of cell adhesion | 61/2218 | 303/18723 | 2.11e-05 | 3.28e-04 | 61 |
| GO:190303419 | Oral cavity | EOLP | regulation of response to wounding | 38/2218 | 167/18723 | 5.06e-05 | 6.58e-04 | 38 |
| GO:006104117 | Oral cavity | EOLP | regulation of wound healing | 32/2218 | 134/18723 | 7.29e-05 | 8.89e-04 | 32 |
| GO:00321023 | Oral cavity | EOLP | negative regulation of response to external stimulus | 75/2218 | 420/18723 | 1.74e-04 | 1.80e-03 | 75 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| AJAP1 | SNV | Missense_Mutation | c.1010C>G | p.Ser337Trp | p.S337W | Q9UKB5 | protein_coding | deleterious(0) | possibly_damaging(0.45) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| AJAP1 | SNV | Missense_Mutation | novel | c.662C>A | p.Thr221Asn | p.T221N | Q9UKB5 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
| AJAP1 | SNV | Missense_Mutation | rs781277874 | c.50C>T | p.Pro17Leu | p.P17L | Q9UKB5 | protein_coding | deleterious(0) | possibly_damaging(0.811) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AJAP1 | SNV | Missense_Mutation | c.871N>C | p.Ile291Leu | p.I291L | Q9UKB5 | protein_coding | deleterious(0.03) | possibly_damaging(0.606) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| AJAP1 | SNV | Missense_Mutation | rs781175711 | c.1124N>T | p.Ser375Leu | p.S375L | Q9UKB5 | protein_coding | tolerated(0.15) | possibly_damaging(0.519) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AJAP1 | SNV | Missense_Mutation | rs567462755 | c.931N>A | p.Gly311Arg | p.G311R | Q9UKB5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| AJAP1 | insertion | Frame_Shift_Ins | novel | c.1204_1205insT | p.Ser403ValfsTer2 | p.S403Vfs*2 | Q9UKB5 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| AJAP1 | insertion | Frame_Shift_Ins | novel | c.1206_1207insGAAACGGGATTTCT | p.Ser403GlufsTer39 | p.S403Efs*39 | Q9UKB5 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| AJAP1 | SNV | Missense_Mutation | rs765357051 | c.254N>A | p.Arg85Gln | p.R85Q | Q9UKB5 | protein_coding | tolerated(0.23) | benign(0.289) | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| AJAP1 | SNV | Missense_Mutation | c.857N>C | p.Ile286Thr | p.I286T | Q9UKB5 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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