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Gene: AFF2 |
Gene summary for AFF2 |
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Gene information | Species | Human | Gene symbol | AFF2 | Gene ID | 2334 |
Gene name | AF4/FMR2 family member 2 | |
Gene Alias | FMR2 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P51816 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2334 | AFF2 | RNA-P17T-P17T-2 | Human | Lung | IAC | 2.13e-03 | 5.69e-01 | 0.3371 |
2334 | AFF2 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.71e-02 | 5.08e-01 | 0.343 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434848 | Lung | IAC | regulation of RNA splicing | 49/2061 | 148/18723 | 4.76e-13 | 7.06e-10 | 49 |
GO:00083808 | Lung | IAC | RNA splicing | 75/2061 | 434/18723 | 4.89e-05 | 1.12e-03 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AFF2 | SNV | Missense_Mutation | c.952N>A | p.Leu318Met | p.L318M | P51816 | protein_coding | tolerated(0.18) | possibly_damaging(0.897) | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AFF2 | SNV | Missense_Mutation | c.1072N>A | p.Glu358Lys | p.E358K | P51816 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AFF2 | SNV | Missense_Mutation | c.2668N>T | p.His890Tyr | p.H890Y | P51816 | protein_coding | deleterious(0.01) | benign(0.357) | TCGA-A2-A259-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
AFF2 | SNV | Missense_Mutation | novel | c.2412N>T | p.Lys804Asn | p.K804N | P51816 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A7-A2KD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
AFF2 | SNV | Missense_Mutation | rs782647821 | c.3343N>T | p.Arg1115Cys | p.R1115C | P51816 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
AFF2 | SNV | Missense_Mutation | novel | c.913N>G | p.Leu305Val | p.L305V | P51816 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AFF2 | SNV | Missense_Mutation | c.1880N>T | p.Gly627Val | p.G627V | P51816 | protein_coding | deleterious(0.05) | possibly_damaging(0.642) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AFF2 | SNV | Missense_Mutation | novel | c.61G>T | p.Asp21Tyr | p.D21Y | P51816 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AFF2 | SNV | Missense_Mutation | novel | c.3556A>G | p.Met1186Val | p.M1186V | P51816 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AFF2 | SNV | Missense_Mutation | c.2371C>G | p.Pro791Ala | p.P791A | P51816 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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