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Gene: AFAP1-AS1 |
Gene summary for AFAP1-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AFAP1-AS1 | Gene ID | 84740 |
Gene name | AFAP1 antisense RNA 1 | |
Gene Alias | AFAP1-AS | |
Cytomap | 4p16.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84740 | AFAP1-AS1 | P5T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.82e-01 | 0.1327 |
84740 | AFAP1-AS1 | P11T-E | Human | Esophagus | ESCC | 1.06e-12 | 5.38e-01 | 0.1426 |
84740 | AFAP1-AS1 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 3.76e-01 | 0.1662 |
84740 | AFAP1-AS1 | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 1.84e-01 | 0.1371 |
84740 | AFAP1-AS1 | P49T-E | Human | Esophagus | ESCC | 2.95e-08 | 5.72e-01 | 0.1768 |
84740 | AFAP1-AS1 | P52T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.87e-01 | 0.1555 |
84740 | AFAP1-AS1 | P107T-E | Human | Esophagus | ESCC | 2.96e-37 | 7.25e-01 | 0.171 |
84740 | AFAP1-AS1 | P128T-E | Human | Esophagus | ESCC | 1.22e-19 | 6.10e-01 | 0.1241 |
84740 | AFAP1-AS1 | P130T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.36e-01 | 0.1676 |
84740 | AFAP1-AS1 | HCC2_Meng | Human | Liver | HCC | 2.13e-27 | 2.15e-01 | 0.0107 |
84740 | AFAP1-AS1 | S027 | Human | Liver | HCC | 3.53e-29 | 1.65e+00 | 0.2446 |
84740 | AFAP1-AS1 | S028 | Human | Liver | HCC | 1.55e-50 | 1.72e+00 | 0.2503 |
84740 | AFAP1-AS1 | S029 | Human | Liver | HCC | 4.67e-39 | 1.66e+00 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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