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Gene: ADTRP |
Gene summary for ADTRP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADTRP | Gene ID | 84830 |
| Gene name | androgen dependent TFPI regulating protein | |
| Gene Alias | AIG1L | |
| Cytomap | 6p24.1 | |
| Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q96IZ2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84830 | ADTRP | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.30e-02 | -3.40e-01 | 0.0155 |
| 84830 | ADTRP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.68e-13 | 6.36e-01 | -0.1954 |
| 84830 | ADTRP | HTA11_83_2000001011 | Human | Colorectum | SER | 4.56e-03 | 5.06e-01 | -0.1526 |
| 84830 | ADTRP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.79e-19 | -4.99e-01 | 0.294 |
| 84830 | ADTRP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.18e-25 | -5.25e-01 | 0.3859 |
| 84830 | ADTRP | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.39e-03 | -5.17e-01 | 0.2585 |
| 84830 | ADTRP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.29e-28 | -5.33e-01 | 0.3005 |
| 84830 | ADTRP | A015-C-203 | Human | Colorectum | FAP | 3.96e-16 | -2.45e-01 | -0.1294 |
| 84830 | ADTRP | A002-C-201 | Human | Colorectum | FAP | 2.19e-03 | -1.49e-01 | 0.0324 |
| 84830 | ADTRP | A001-C-108 | Human | Colorectum | FAP | 1.45e-14 | -4.07e-01 | -0.0272 |
| 84830 | ADTRP | A002-C-205 | Human | Colorectum | FAP | 4.13e-06 | -1.41e-01 | -0.1236 |
| 84830 | ADTRP | A001-C-104 | Human | Colorectum | FAP | 1.00e-08 | -3.31e-01 | 0.0184 |
| 84830 | ADTRP | A015-C-006 | Human | Colorectum | FAP | 1.01e-06 | -4.05e-01 | -0.0994 |
| 84830 | ADTRP | A015-C-106 | Human | Colorectum | FAP | 2.09e-08 | -2.56e-01 | -0.0511 |
| 84830 | ADTRP | A002-C-114 | Human | Colorectum | FAP | 1.18e-06 | -2.71e-01 | -0.1561 |
| 84830 | ADTRP | A015-C-104 | Human | Colorectum | FAP | 2.33e-15 | -2.68e-01 | -0.1899 |
| 84830 | ADTRP | A001-C-014 | Human | Colorectum | FAP | 1.58e-10 | -3.29e-01 | 0.0135 |
| 84830 | ADTRP | A002-C-016 | Human | Colorectum | FAP | 1.77e-10 | -1.45e-01 | 0.0521 |
| 84830 | ADTRP | A015-C-002 | Human | Colorectum | FAP | 1.19e-03 | -3.66e-01 | -0.0763 |
| 84830 | ADTRP | A001-C-007 | Human | Colorectum | CRC | 1.38e-04 | -5.13e-01 | 0.1899 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
| GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
| GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
| GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
| GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
| GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
| GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
| GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
| GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
| GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
| GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
| GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
| GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
| GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
| GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
| GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
| GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
| GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
| GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
| GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADTRP | SNV | Missense_Mutation | novel | c.49N>C | p.Tyr17His | p.Y17H | Q96IZ2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADTRP | SNV | Missense_Mutation | novel | c.539N>G | p.Ala180Gly | p.A180G | Q96IZ2 | protein_coding | tolerated(0.5) | benign(0.005) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
| ADTRP | insertion | Frame_Shift_Ins | novel | c.268_269insAGCTGGGGTTCAAACCCAGTATGTCTGACTCCCAAGTAGTGATTTTTCTTCACTTACA | p.Gly90GlufsTer25 | p.G90Efs*25 | Q96IZ2 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ADTRP | SNV | Missense_Mutation | novel | c.145N>A | p.Leu49Ile | p.L49I | Q96IZ2 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
| ADTRP | SNV | Missense_Mutation | c.139N>C | p.Thr47Pro | p.T47P | Q96IZ2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| ADTRP | SNV | Missense_Mutation | c.387N>A | p.Asp129Glu | p.D129E | Q96IZ2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ADTRP | SNV | Missense_Mutation | novel | c.444N>T | p.Met148Ile | p.M148I | Q96IZ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.513) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ADTRP | SNV | Missense_Mutation | rs367932994 | c.383N>A | p.Arg128Gln | p.R128Q | Q96IZ2 | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADTRP | SNV | Missense_Mutation | novel | c.104N>C | p.Lys35Thr | p.K35T | Q96IZ2 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADTRP | SNV | Missense_Mutation | rs145096274 | c.584N>T | p.Thr195Met | p.T195M | Q96IZ2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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