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Gene: ADRBK1 |
Gene summary for ADRBK1 |
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Gene information | Species | Human | Gene symbol | ADRBK1 | Gene ID | 156 |
Gene name | G protein-coupled receptor kinase 2 | |
Gene Alias | ADRBK1 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002026 | UniProtAcc | A0A0S2Z392 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
156 | ADRBK1 | P1T-E | Human | Esophagus | ESCC | 2.65e-12 | 5.10e-01 | 0.0875 |
156 | ADRBK1 | P2T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.35e-01 | 0.1177 |
156 | ADRBK1 | P4T-E | Human | Esophagus | ESCC | 4.27e-09 | 2.35e-01 | 0.1323 |
156 | ADRBK1 | P5T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.08e-01 | 0.1327 |
156 | ADRBK1 | P8T-E | Human | Esophagus | ESCC | 5.22e-43 | 6.90e-01 | 0.0889 |
156 | ADRBK1 | P9T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.08e-01 | 0.1131 |
156 | ADRBK1 | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.66e-01 | 0.116 |
156 | ADRBK1 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.22e-01 | 0.1426 |
156 | ADRBK1 | P12T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.25e-01 | 0.1122 |
156 | ADRBK1 | P15T-E | Human | Esophagus | ESCC | 4.29e-21 | 4.01e-01 | 0.1149 |
156 | ADRBK1 | P16T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.32e-01 | 0.1153 |
156 | ADRBK1 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 2.38e-01 | 0.1278 |
156 | ADRBK1 | P20T-E | Human | Esophagus | ESCC | 1.73e-12 | 2.56e-01 | 0.1124 |
156 | ADRBK1 | P21T-E | Human | Esophagus | ESCC | 5.79e-16 | 3.10e-01 | 0.1617 |
156 | ADRBK1 | P22T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.40e-01 | 0.1236 |
156 | ADRBK1 | P23T-E | Human | Esophagus | ESCC | 6.05e-08 | 1.93e-01 | 0.108 |
156 | ADRBK1 | P24T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.82e-01 | 0.1287 |
156 | ADRBK1 | P26T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.02e-01 | 0.1276 |
156 | ADRBK1 | P27T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.29e-01 | 0.1055 |
156 | ADRBK1 | P28T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.33e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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