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Gene: ADGRE3 |
Gene summary for ADGRE3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADGRE3 | Gene ID | 84658 |
| Gene name | adhesion G protein-coupled receptor E3 | |
| Gene Alias | EMR3 | |
| Cytomap | 19p13.12 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A1L1B9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84658 | ADGRE3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.77e-13 | 5.82e-01 | -0.1088 |
| 84658 | ADGRE3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.51e-17 | 5.80e-01 | -0.1954 |
| 84658 | ADGRE3 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.05e-03 | 5.59e-01 | -0.2602 |
| 84658 | ADGRE3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.94e-03 | 5.26e-01 | -0.2061 |
| 84658 | ADGRE3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.84e-02 | 2.46e-01 | 0.096 |
| 84658 | ADGRE3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.92e-05 | 6.04e-01 | 0.0171 |
| 84658 | ADGRE3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.93e-05 | 1.96e-01 | 0.0674 |
| 84658 | ADGRE3 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.06e-02 | 5.61e-01 | -0.0124 |
| 84658 | ADGRE3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.26e-28 | 7.14e-01 | 0.294 |
| 84658 | ADGRE3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.79e-12 | 5.31e-01 | 0.281 |
| 84658 | ADGRE3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.99e-11 | 3.91e-01 | 0.3859 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADGRE3 | SNV | Missense_Mutation | c.47N>A | p.Leu16His | p.L16H | Q9BY15 | protein_coding | deleterious(0.01) | possibly_damaging(0.552) | TCGA-A2-A0SU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| ADGRE3 | SNV | Missense_Mutation | c.1355N>T | p.Thr452Ile | p.T452I | Q9BY15 | protein_coding | deleterious(0.01) | possibly_damaging(0.733) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
| ADGRE3 | SNV | Missense_Mutation | c.802N>G | p.Gln268Glu | p.Q268E | Q9BY15 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ADGRE3 | SNV | Missense_Mutation | novel | c.1634N>G | p.Gln545Arg | p.Q545R | Q9BY15 | protein_coding | tolerated(0.15) | benign(0.06) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADGRE3 | SNV | Missense_Mutation | c.1828C>G | p.Gln610Glu | p.Q610E | Q9BY15 | protein_coding | deleterious(0.05) | benign(0.011) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ADGRE3 | SNV | Missense_Mutation | c.1445N>T | p.Ser482Phe | p.S482F | Q9BY15 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ADGRE3 | SNV | Missense_Mutation | rs559170756 | c.1420G>A | p.Val474Ile | p.V474I | Q9BY15 | protein_coding | tolerated(0.25) | benign(0.179) | TCGA-EW-A2FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | goserelin | SD |
| ADGRE3 | insertion | Nonsense_Mutation | novel | c.416_417insAGGAGGCTGAGGTGGGAGGATCGCTTGAGCCCAGGAGTTCGAG | p.Phe139LeufsTer4 | p.F139Lfs*4 | Q9BY15 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
| ADGRE3 | insertion | Nonsense_Mutation | novel | c.1843_1844insGAAAATCACTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCA | p.Glu615delinsGlyLysSerLeuGluProGluArgArgArgLeuGlnTerAlaLys | p.E615delinsGKSLEPERRRLQ*AK | Q9BY15 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
| ADGRE3 | deletion | Frame_Shift_Del | novel | c.21delN | p.Pro8GlnfsTer7 | p.P8Qfs*7 | Q9BY15 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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