Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ADGRA2

Gene summary for ADGRA2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ADGRA2

Gene ID

25960

Gene nameadhesion G protein-coupled receptor A2
Gene AliasGPR124
Cytomap8p11.23
Gene Typeprotein-coding
GO ID

GO:0001525

UniProtAcc

Q6YN44


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
25960ADGRA2ATC11HumanThyroidATC8.59e-043.97e-010.3386
25960ADGRA2ATC12HumanThyroidATC1.54e-204.26e-010.34
25960ADGRA2ATC13HumanThyroidATC1.12e-751.29e+000.34
25960ADGRA2ATC2HumanThyroidATC1.53e-076.54e-010.34
25960ADGRA2ATC4HumanThyroidATC3.73e-235.32e-010.34
25960ADGRA2ATC5HumanThyroidATC1.28e-781.37e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001605525ThyroidATCWnt signaling pathway234/6293444/187234.64e-174.31e-15234
GO:019873825ThyroidATCcell-cell signaling by wnt234/6293446/187239.26e-178.25e-15234
GO:003011125ThyroidATCregulation of Wnt signaling pathway177/6293328/187231.83e-141.05e-12177
GO:000166731ThyroidATCameboidal-type cell migration228/6293475/187233.72e-111.22e-09228
GO:006082825ThyroidATCregulation of canonical Wnt signaling pathway134/6293253/187231.49e-104.56e-09134
GO:006007025ThyroidATCcanonical Wnt signaling pathway154/6293303/187233.68e-101.02e-08154
GO:0030177110ThyroidATCpositive regulation of Wnt signaling pathway80/6293140/187238.75e-091.86e-0780
GO:001063131ThyroidATCepithelial cell migration169/6293357/187234.21e-087.69e-07169
GO:009013031ThyroidATCtissue migration171/6293365/187238.55e-081.47e-06171
GO:009013231ThyroidATCepithelium migration169/6293360/187238.57e-081.47e-06169
GO:0090263110ThyroidATCpositive regulation of canonical Wnt signaling pathway62/6293106/187231.26e-072.09e-0662
GO:001063432ThyroidATCpositive regulation of epithelial cell migration92/6293176/187232.38e-073.70e-0692
GO:001063231ThyroidATCregulation of epithelial cell migration137/6293292/187231.44e-061.77e-05137
GO:009028721ThyroidATCregulation of cellular response to growth factor stimulus140/6293304/187233.91e-064.33e-05140
GO:004354231ThyroidATCendothelial cell migration127/6293279/187232.14e-051.91e-04127
GO:001059531ThyroidATCpositive regulation of endothelial cell migration67/6293133/187234.61e-053.70e-0467
GO:00509206ThyroidATCregulation of chemotaxis99/6293223/187234.91e-042.86e-0399
GO:001059431ThyroidATCregulation of endothelial cell migration102/6293232/187236.17e-043.51e-03102
GO:00457657ThyroidATCregulation of angiogenesis141/6293342/187231.80e-038.85e-03141
GO:19013427ThyroidATCregulation of vasculature development143/6293348/187231.95e-039.44e-03143
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ADGRA2SNVMissense_Mutationnovelc.342N>Gp.Asp114Glup.D114EQ96PE1protein_codingdeleterious(0.02)probably_damaging(0.976)TCGA-AC-A3W5-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydocetaxelCR
ADGRA2SNVMissense_Mutationnovelc.1160N>Tp.Ser387Leup.S387LQ96PE1protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A0B6-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ADGRA2insertionNonsense_Mutationnovelc.1774_1775insCTGGGTGACATAGCAAGAATCTGTp.Leu592delinsProGlyTerHisSerLysAsnLeuPhep.L592delinsPG*HSKNLFQ96PE1protein_codingTCGA-A2-A0CM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinPD
ADGRA2insertionFrame_Shift_Insnovelc.1832_1833insTCCTCp.Lys611AsnfsTer83p.K611Nfs*83Q96PE1protein_codingTCGA-A8-A085-01Breastbreast invasive carcinomaMale<65I/IIHormone TherapytamoxiphenSD
ADGRA2deletionFrame_Shift_Delc.1567delNp.Ala525ProfsTer12p.A525Pfs*12Q96PE1protein_codingTCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ADGRA2deletionFrame_Shift_Delnovelc.417delNp.Ser140ProfsTer22p.S140Pfs*22Q96PE1protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ADGRA2SNVMissense_Mutationrs567572116c.374N>Tp.Pro125Leup.P125LQ96PE1protein_codingdeleterious(0)probably_damaging(0.999)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ADGRA2SNVMissense_Mutationnovelc.1404N>Cp.Gln468Hisp.Q468HQ96PE1protein_codingtolerated(0.27)probably_damaging(0.923)TCGA-C5-A2M1-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ADGRA2SNVMissense_Mutationnovelc.1630N>Cp.Glu544Glnp.E544QQ96PE1protein_codingdeleterious(0)possibly_damaging(0.903)TCGA-EK-A2RM-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ADGRA2SNVMissense_Mutationrs751263844c.397N>Ap.Glu133Lysp.E133KQ96PE1protein_codingtolerated(0.14)benign(0.091)TCGA-MY-A5BD-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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