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Gene: ADAMTSL4 |
Gene summary for ADAMTSL4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADAMTSL4 | Gene ID | 54507 |
| Gene name | ADAMTS like 4 | |
| Gene Alias | ADAMTSL-4 | |
| Cytomap | 1q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0002064 | UniProtAcc | B7ZMJ3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54507 | ADAMTSL4 | PTC04 | Human | Thyroid | PTC | 1.28e-06 | 2.18e-01 | 0.1927 |
| 54507 | ADAMTSL4 | ATC13 | Human | Thyroid | ATC | 4.23e-28 | 5.57e-01 | 0.34 |
| 54507 | ADAMTSL4 | ATC5 | Human | Thyroid | ATC | 1.12e-33 | 6.06e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0002064112 | Thyroid | PTC | epithelial cell development | 101/5968 | 220/18723 | 8.53e-06 | 9.74e-05 | 101 |
| GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
| GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
| GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
| GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
| GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
| GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
| GO:000206428 | Thyroid | ATC | epithelial cell development | 103/6293 | 220/18723 | 3.06e-05 | 2.55e-04 | 103 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADAMTSL4 | SNV | Missense_Mutation | novel | c.1406N>A | p.Gly469Glu | p.G469E | Q6UY14 | protein_coding | deleterious(0.01) | probably_damaging(0.918) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| ADAMTSL4 | SNV | Missense_Mutation | c.389N>A | p.Ser130Tyr | p.S130Y | Q6UY14 | protein_coding | tolerated(0.24) | possibly_damaging(0.748) | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| ADAMTSL4 | SNV | Missense_Mutation | novel | c.2602N>C | p.Trp868Arg | p.W868R | Q6UY14 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0BO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ADAMTSL4 | SNV | Missense_Mutation | c.406N>A | p.Glu136Lys | p.E136K | Q6UY14 | protein_coding | tolerated(0.17) | benign(0.009) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
| ADAMTSL4 | SNV | Missense_Mutation | c.2889A>T | p.Lys963Asn | p.K963N | Q6UY14 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ADAMTSL4 | insertion | Frame_Shift_Ins | novel | c.1329_1330insC | p.Asn444GlnfsTer15 | p.N444Qfs*15 | Q6UY14 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| ADAMTSL4 | insertion | Frame_Shift_Ins | novel | c.1331_1332insCCTCTGCTTCCTGGGTTCAAGCAATTCTC | p.Cys445LeufsTer46 | p.C445Lfs*46 | Q6UY14 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| ADAMTSL4 | insertion | In_Frame_Ins | novel | c.1412_1413insTCT | p.Pro471_Asp472insLeu | p.P471_D472insL | Q6UY14 | protein_coding | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
| ADAMTSL4 | insertion | Nonsense_Mutation | novel | c.1414_1415insACACCGGGATAAGCACTCAAGAGCTCTGA | p.Ile473ThrfsTer9 | p.I473Tfs*9 | Q6UY14 | protein_coding | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
| ADAMTSL4 | insertion | In_Frame_Ins | novel | c.1886_1887insGCACCTGTCCATGTCCCTGGGTCTGGCTGGGGATGG | p.Leu629_Glu630insHisLeuSerMetSerLeuGlyLeuAlaGlyAspGly | p.L629_E630insHLSMSLGLAGDG | Q6UY14 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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