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Gene: ADAMTSL3 |
Gene summary for ADAMTSL3 |
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Gene information | Species | Human | Gene symbol | ADAMTSL3 | Gene ID | 57188 |
Gene name | ADAMTS like 3 | |
Gene Alias | ADAMTSL-3 | |
Cytomap | 15q25.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P82987 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57188 | ADAMTSL3 | NAFLD1 | Human | Liver | NAFLD | 8.32e-10 | 6.29e-01 | -0.04 |
57188 | ADAMTSL3 | S41 | Human | Liver | Cirrhotic | 1.19e-05 | 6.24e-01 | -0.0343 |
57188 | ADAMTSL3 | HCC1_Meng | Human | Liver | HCC | 2.02e-11 | -2.07e-01 | 0.0246 |
57188 | ADAMTSL3 | HCC2_Meng | Human | Liver | HCC | 6.30e-04 | -2.03e-01 | 0.0107 |
57188 | ADAMTSL3 | cirrhotic1 | Human | Liver | Cirrhotic | 5.99e-03 | -1.98e-01 | 0.0202 |
57188 | ADAMTSL3 | cirrhotic2 | Human | Liver | Cirrhotic | 5.48e-03 | -1.98e-01 | 0.0201 |
57188 | ADAMTSL3 | HCC2 | Human | Liver | HCC | 9.48e-04 | 3.23e+00 | 0.5341 |
57188 | ADAMTSL3 | Pt13.b | Human | Liver | HCC | 2.55e-06 | -3.38e-02 | 0.0251 |
57188 | ADAMTSL3 | Pt14.d | Human | Liver | HCC | 1.90e-02 | -2.05e-01 | 0.0143 |
57188 | ADAMTSL3 | S029 | Human | Liver | HCC | 2.17e-03 | 5.84e-02 | 0.2581 |
57188 | ADAMTSL3 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 5.78e-12 | 6.35e-01 | 0.1633 |
57188 | ADAMTSL3 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.19e-20 | 7.97e-01 | 0.1608 |
57188 | ADAMTSL3 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 3.39e-11 | 6.86e-01 | 0.1604 |
57188 | ADAMTSL3 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.67e-04 | 3.81e-01 | 0.1621 |
57188 | ADAMTSL3 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 3.69e-04 | 3.43e-01 | 0.1575 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTSL3 | SNV | Missense_Mutation | rs146998252 | c.3328N>A | p.Gly1110Arg | p.G1110R | P82987 | protein_coding | deleterious(0.04) | benign(0.041) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ADAMTSL3 | SNV | Missense_Mutation | c.3699N>C | p.Leu1233Phe | p.L1233F | P82987 | protein_coding | tolerated(0.05) | possibly_damaging(0.522) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
ADAMTSL3 | SNV | Missense_Mutation | c.2635G>C | p.Glu879Gln | p.E879Q | P82987 | protein_coding | tolerated(0.22) | benign(0.097) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTSL3 | SNV | Missense_Mutation | c.107C>T | p.Pro36Leu | p.P36L | P82987 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
ADAMTSL3 | SNV | Missense_Mutation | rs763892662 | c.957N>G | p.Phe319Leu | p.F319L | P82987 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ADAMTSL3 | SNV | Missense_Mutation | c.1672N>C | p.Glu558Gln | p.E558Q | P82987 | protein_coding | deleterious(0.03) | benign(0.209) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
ADAMTSL3 | SNV | Missense_Mutation | rs780250062 | c.2218C>T | p.Pro740Ser | p.P740S | P82987 | protein_coding | tolerated(0.77) | benign(0.005) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ADAMTSL3 | SNV | Missense_Mutation | novel | c.5049N>T | p.Arg1683Ser | p.R1683S | P82987 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ADAMTSL3 | SNV | Missense_Mutation | c.3377C>T | p.Ala1126Val | p.A1126V | P82987 | protein_coding | tolerated(0.07) | possibly_damaging(0.793) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
ADAMTSL3 | SNV | Missense_Mutation | rs780788189 | c.3010N>A | p.Ala1004Thr | p.A1004T | P82987 | protein_coding | tolerated(0.25) | benign(0.125) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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