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Gene: ADAMTS14 |
Gene summary for ADAMTS14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADAMTS14 | Gene ID | 140766 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |
| Gene Alias | ADAMTS14 | |
| Cytomap | 10q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8WXS8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 140766 | ADAMTS14 | ATC11 | Human | Thyroid | ATC | 2.49e-06 | 4.38e-01 | 0.3386 |
| 140766 | ADAMTS14 | ATC12 | Human | Thyroid | ATC | 1.28e-08 | 2.78e-01 | 0.34 |
| 140766 | ADAMTS14 | ATC13 | Human | Thyroid | ATC | 5.13e-22 | 4.36e-01 | 0.34 |
| 140766 | ADAMTS14 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 6.90e-01 | 0.34 |
| 140766 | ADAMTS14 | ATC3 | Human | Thyroid | ATC | 1.86e-15 | 7.30e-01 | 0.338 |
| 140766 | ADAMTS14 | ATC4 | Human | Thyroid | ATC | 2.71e-11 | 3.34e-01 | 0.34 |
| 140766 | ADAMTS14 | ATC5 | Human | Thyroid | ATC | 1.14e-29 | 4.70e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
| GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
| GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
| GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
| GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADAMTS14 | SNV | Missense_Mutation | novel | c.1800N>T | p.Glu600Asp | p.E600D | Q8WXS8 | protein_coding | tolerated(0.28) | benign(0.03) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
| ADAMTS14 | SNV | Missense_Mutation | c.1497C>G | p.Phe499Leu | p.F499L | Q8WXS8 | protein_coding | tolerated(0.05) | benign(0.009) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ADAMTS14 | SNV | Missense_Mutation | rs781417210 | c.1457N>A | p.Arg486His | p.R486H | Q8WXS8 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADAMTS14 | SNV | Missense_Mutation | c.1667N>T | p.Gly556Val | p.G556V | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ADAMTS14 | SNV | Missense_Mutation | novel | c.2632N>T | p.Arg878Trp | p.R878W | Q8WXS8 | protein_coding | deleterious(0) | possibly_damaging(0.634) | TCGA-AQ-A54O-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | adriamycin | CR |
| ADAMTS14 | SNV | Missense_Mutation | rs776328715 | c.622N>T | p.Arg208Cys | p.R208C | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
| ADAMTS14 | SNV | Missense_Mutation | c.2557N>C | p.Glu853Gln | p.E853Q | Q8WXS8 | protein_coding | deleterious(0.01) | possibly_damaging(0.84) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| ADAMTS14 | insertion | In_Frame_Ins | novel | c.1815_1816insCCCAACTCCATGGTTTTGGGATATCTG | p.Asn605_Ser606insProAsnSerMetValLeuGlyTyrLeu | p.N605_S606insPNSMVLGYL | Q8WXS8 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| ADAMTS14 | insertion | Nonsense_Mutation | novel | c.1048_1049insGAAACTGACGATTCCACACCTTTATCACTGGGAGATCC | p.Ala350GlyfsTer3 | p.A350Gfs*3 | Q8WXS8 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ADAMTS14 | insertion | Frame_Shift_Ins | novel | c.1629_1630insCCCCTGCCTCCTGCCCTAGCCAGGCTCCTCCT | p.Ile544ProfsTer63 | p.I544Pfs*63 | Q8WXS8 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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