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Gene: ACTRT3 |
Gene summary for ACTRT3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ACTRT3 | Gene ID | 84517 |
| Gene name | actin related protein T3 | |
| Gene Alias | ARP-T3 | |
| Cytomap | 3q26.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BYD9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84517 | ACTRT3 | P2T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.14e-01 | 0.1177 |
| 84517 | ACTRT3 | P4T-E | Human | Esophagus | ESCC | 8.33e-13 | 3.48e-01 | 0.1323 |
| 84517 | ACTRT3 | P5T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.64e-01 | 0.1327 |
| 84517 | ACTRT3 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.91e-01 | 0.1426 |
| 84517 | ACTRT3 | P16T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.85e-01 | 0.1153 |
| 84517 | ACTRT3 | P22T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.22e-01 | 0.1236 |
| 84517 | ACTRT3 | P36T-E | Human | Esophagus | ESCC | 2.09e-07 | 3.34e-01 | 0.1187 |
| 84517 | ACTRT3 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 1.05e-01 | 0.1175 |
| 84517 | ACTRT3 | P47T-E | Human | Esophagus | ESCC | 2.05e-07 | 2.45e-01 | 0.1067 |
| 84517 | ACTRT3 | P49T-E | Human | Esophagus | ESCC | 6.53e-04 | 6.20e-01 | 0.1768 |
| 84517 | ACTRT3 | P52T-E | Human | Esophagus | ESCC | 1.97e-10 | 4.27e-01 | 0.1555 |
| 84517 | ACTRT3 | P74T-E | Human | Esophagus | ESCC | 8.28e-10 | 4.96e-01 | 0.1479 |
| 84517 | ACTRT3 | P79T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.14e-01 | 0.1154 |
| 84517 | ACTRT3 | P83T-E | Human | Esophagus | ESCC | 3.53e-13 | 3.98e-01 | 0.1738 |
| 84517 | ACTRT3 | P89T-E | Human | Esophagus | ESCC | 3.85e-03 | 2.94e-01 | 0.1752 |
| 84517 | ACTRT3 | P91T-E | Human | Esophagus | ESCC | 2.11e-02 | 3.18e-01 | 0.1828 |
| 84517 | ACTRT3 | P107T-E | Human | Esophagus | ESCC | 2.08e-04 | 1.36e-01 | 0.171 |
| 84517 | ACTRT3 | P128T-E | Human | Esophagus | ESCC | 7.29e-13 | 5.29e-01 | 0.1241 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ACTRT3 | SNV | Missense_Mutation | c.814N>A | p.Asp272Asn | p.D272N | Q9BYD9 | protein_coding | deleterious(0.04) | possibly_damaging(0.894) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ACTRT3 | SNV | Missense_Mutation | c.886N>G | p.Leu296Val | p.L296V | Q9BYD9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EK-A2R9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ACTRT3 | SNV | Missense_Mutation | novel | c.217N>A | p.Gly73Ser | p.G73S | Q9BYD9 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ACTRT3 | SNV | Missense_Mutation | rs776125776 | c.290N>T | p.Pro97Leu | p.P97L | Q9BYD9 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| ACTRT3 | SNV | Missense_Mutation | novel | c.773N>A | p.Leu258His | p.L258H | Q9BYD9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
| ACTRT3 | SNV | Missense_Mutation | novel | c.181A>G | p.Arg61Gly | p.R61G | Q9BYD9 | protein_coding | deleterious(0.01) | benign(0.029) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACTRT3 | insertion | Frame_Shift_Ins | novel | c.877_878insCACTG | p.Asn293ThrfsTer16 | p.N293Tfs*16 | Q9BYD9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ACTRT3 | SNV | Missense_Mutation | c.497N>G | p.Glu166Gly | p.E166G | Q9BYD9 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| ACTRT3 | SNV | Missense_Mutation | novel | c.890C>T | p.Ala297Val | p.A297V | Q9BYD9 | protein_coding | deleterious(0) | possibly_damaging(0.575) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| ACTRT3 | SNV | Missense_Mutation | novel | c.284N>C | p.Leu95Pro | p.L95P | Q9BYD9 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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