|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ACTR10 |
Gene summary for ACTR10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ACTR10 | Gene ID | 55860 |
| Gene name | actin related protein 10 | |
| Gene Alias | ACTR11 | |
| Cytomap | 14q23.1 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NZ32 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55860 | ACTR10 | LZE4T | Human | Esophagus | ESCC | 5.15e-23 | 7.28e-01 | 0.0811 |
| 55860 | ACTR10 | LZE5T | Human | Esophagus | ESCC | 1.07e-04 | 9.31e-01 | 0.0514 |
| 55860 | ACTR10 | LZE7T | Human | Esophagus | ESCC | 1.91e-03 | 2.31e-01 | 0.0667 |
| 55860 | ACTR10 | LZE8T | Human | Esophagus | ESCC | 4.11e-06 | 2.81e-01 | 0.067 |
| 55860 | ACTR10 | LZE20T | Human | Esophagus | ESCC | 7.83e-15 | 6.33e-01 | 0.0662 |
| 55860 | ACTR10 | LZE22D1 | Human | Esophagus | HGIN | 1.19e-03 | 1.03e-01 | 0.0595 |
| 55860 | ACTR10 | LZE24T | Human | Esophagus | ESCC | 4.33e-21 | 8.27e-01 | 0.0596 |
| 55860 | ACTR10 | LZE21T | Human | Esophagus | ESCC | 4.10e-02 | 5.04e-01 | 0.0655 |
| 55860 | ACTR10 | LZE6T | Human | Esophagus | ESCC | 3.83e-03 | 4.02e-01 | 0.0845 |
| 55860 | ACTR10 | P1T-E | Human | Esophagus | ESCC | 1.88e-11 | 5.17e-01 | 0.0875 |
| 55860 | ACTR10 | P2T-E | Human | Esophagus | ESCC | 3.02e-30 | 5.43e-01 | 0.1177 |
| 55860 | ACTR10 | P4T-E | Human | Esophagus | ESCC | 7.63e-34 | 8.02e-01 | 0.1323 |
| 55860 | ACTR10 | P5T-E | Human | Esophagus | ESCC | 2.61e-24 | 5.81e-01 | 0.1327 |
| 55860 | ACTR10 | P8T-E | Human | Esophagus | ESCC | 2.69e-39 | 7.26e-01 | 0.0889 |
| 55860 | ACTR10 | P9T-E | Human | Esophagus | ESCC | 1.87e-17 | 4.35e-01 | 0.1131 |
| 55860 | ACTR10 | P10T-E | Human | Esophagus | ESCC | 1.59e-46 | 8.22e-01 | 0.116 |
| 55860 | ACTR10 | P11T-E | Human | Esophagus | ESCC | 1.65e-21 | 8.81e-01 | 0.1426 |
| 55860 | ACTR10 | P12T-E | Human | Esophagus | ESCC | 6.30e-51 | 1.08e+00 | 0.1122 |
| 55860 | ACTR10 | P15T-E | Human | Esophagus | ESCC | 8.76e-56 | 1.26e+00 | 0.1149 |
| 55860 | ACTR10 | P16T-E | Human | Esophagus | ESCC | 1.17e-30 | 5.91e-01 | 0.1153 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
| GO:003070517 | Esophagus | HGIN | cytoskeleton-dependent intracellular transport | 45/2587 | 195/18723 | 3.07e-04 | 5.15e-03 | 45 |
| GO:00109707 | Esophagus | HGIN | transport along microtubule | 35/2587 | 155/18723 | 2.01e-03 | 2.12e-02 | 35 |
| GO:00516542 | Esophagus | HGIN | establishment of mitochondrion localization | 10/2587 | 29/18723 | 4.07e-03 | 3.65e-02 | 10 |
| GO:00346432 | Esophagus | HGIN | establishment of mitochondrion localization, microtubule-mediated | 9/2587 | 26/18723 | 6.15e-03 | 4.92e-02 | 9 |
| GO:00474972 | Esophagus | HGIN | mitochondrion transport along microtubule | 9/2587 | 26/18723 | 6.15e-03 | 4.92e-02 | 9 |
| GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
| GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
| GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
| GO:00723846 | Esophagus | ESCC | organelle transport along microtubule | 65/8552 | 85/18723 | 6.61e-09 | 1.35e-07 | 65 |
| GO:000808810 | Esophagus | ESCC | axo-dendritic transport | 58/8552 | 75/18723 | 2.09e-08 | 4.02e-07 | 58 |
| GO:00989304 | Esophagus | ESCC | axonal transport | 49/8552 | 64/18723 | 4.54e-07 | 6.15e-06 | 49 |
| GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
| GO:005165411 | Esophagus | ESCC | establishment of mitochondrion localization | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
| GO:00346431 | Esophagus | ESCC | establishment of mitochondrion localization, microtubule-mediated | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
| GO:00474971 | Esophagus | ESCC | mitochondrion transport along microtubule | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
| GO:00516463 | Esophagus | ESCC | mitochondrion localization | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
| GO:005165611 | Liver | Cirrhotic | establishment of organelle localization | 128/4634 | 390/18723 | 1.78e-04 | 1.67e-03 | 128 |
| GO:003070511 | Liver | Cirrhotic | cytoskeleton-dependent intracellular transport | 68/4634 | 195/18723 | 9.54e-04 | 6.77e-03 | 68 |
| GO:000808811 | Liver | Cirrhotic | axo-dendritic transport | 29/4634 | 75/18723 | 5.24e-03 | 2.69e-02 | 29 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
| hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
| hsa0502230 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
| hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
| hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
| hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
| hsa05022113 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
| hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
| hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
| hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
| hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
| hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
| hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
| hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
| hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
| hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
| hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
| hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
| hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
| hsa0513222 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
| Page: 1 2 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ACTR10 | SNV | Missense_Mutation | rs554639681 | c.1025N>A | p.Arg342Gln | p.R342Q | Q9NZ32 | protein_coding | tolerated(0.07) | benign(0.095) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACTR10 | SNV | Missense_Mutation | c.658N>G | p.Leu220Val | p.L220V | Q9NZ32 | protein_coding | tolerated(0.08) | benign(0.314) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
| ACTR10 | SNV | Missense_Mutation | c.1048N>A | p.Ala350Thr | p.A350T | Q9NZ32 | protein_coding | tolerated(0.16) | benign(0.305) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ACTR10 | SNV | Missense_Mutation | rs554639681 | c.1025N>A | p.Arg342Gln | p.R342Q | Q9NZ32 | protein_coding | tolerated(0.07) | benign(0.095) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ACTR10 | SNV | Missense_Mutation | rs554639681 | c.1025N>A | p.Arg342Gln | p.R342Q | Q9NZ32 | protein_coding | tolerated(0.07) | benign(0.095) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ACTR10 | SNV | Missense_Mutation | rs554639681 | c.1025G>A | p.Arg342Gln | p.R342Q | Q9NZ32 | protein_coding | tolerated(0.07) | benign(0.095) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ACTR10 | SNV | Missense_Mutation | rs554639681 | c.1025G>A | p.Arg342Gln | p.R342Q | Q9NZ32 | protein_coding | tolerated(0.07) | benign(0.095) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| ACTR10 | SNV | Missense_Mutation | rs757930478 | c.515A>G | p.His172Arg | p.H172R | Q9NZ32 | protein_coding | deleterious(0.01) | benign(0.116) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ACTR10 | SNV | Missense_Mutation | rs760553331 | c.1147N>T | p.Arg383Cys | p.R383C | Q9NZ32 | protein_coding | deleterious(0.02) | possibly_damaging(0.761) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
| ACTR10 | SNV | Missense_Mutation | c.856N>A | p.Asp286Asn | p.D286N | Q9NZ32 | protein_coding | tolerated(0.15) | possibly_damaging(0.724) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |